본문 바로가기
KERD
논문KCI 등재

Therapeutic Effects of Resiniferatoxin Related with Immunological Responses for Intestinal Inflammation in Trichinellosis

José Luis Muñoz-Carrillo|José Luis Muñoz-López|José Jesús Muñoz-Escobedo|Claudia Maldonado-Tapia|Oscar Gutiérrez-Coronado|Juan Francisco Contreras-Cordero|María Alejandra Moreno-García
대한기생충학ㆍ열대의학회 (The Korean Society For Parasitology and Tropical Medicine)|2017.12|Parasites, Hosts and Diseases|제55권 제6호|pp. 587-599

2

조회

0

다운로드

0

인용

0

참고문헌

키워드

Trichinella spiralisTh1 cytokinetrichinellosisinflammatory responseresiniferatoxin
주제분류예방의학/직업환경의학

초록

The immune response against Trichinella spiralis at the intestinal level depends on the CD4+ T cells, which can both suppress or promote the inflammatory response through the synthesis of diverse cytokines. During the intestinal phase, the immune response is mixed (Th1/Th2) with the initial predominance of the Th1 response and the subsequent domination of Th2 response, which favor the development of intestinal pathology. In this context, the glucocorticoids (GC) are the pharmacotherapy for the intestinal inflammatory response in trichinellosis. However, its therapeutic use is limited, since studies have shown that treatment with GC suppresses the host immune system, favoring T. spiralis infection. In the search for novel pharmacological strategies that inhibit the Th1 immune response (proinflammatory) and assist the host against T. spiralis infection, recent studies showed that resiniferatoxin (RTX) had anti-inflammatory activity, which decreased the serum levels of IL-12, INF-γ, IL-1β, TNF-α, NO, and PGE2, as well the number of eosinophils in the blood, associated with decreased intestinal pathology and muscle parasite burden. These researches demonstrate that RTX is capable to inhibit the production of Th1 cytokines, contributing to the defense against T. spiralis infection, which places it as a new potential drug modulator of the immune response.

Abstract

The immune response against Trichinella spiralis at the intestinal level depends on the CD4+ T cells, which can both suppress or promote the inflammatory response through the synthesis of diverse cytokines. During the intestinal phase, the immune response is mixed (Th1/Th2) with the initial predominance of the Th1 response and the subsequent domination of Th2 response, which favor the development of intestinal pathology. In this context, the glucocorticoids (GC) are the pharmacotherapy for the intestinal inflammatory response in trichinellosis. However, its therapeutic use is limited, since studies have shown that treatment with GC suppresses the host immune system, favoring T. spiralis infection. In the search for novel pharmacological strategies that inhibit the Th1 immune response (proinflammatory) and assist the host against T. spiralis infection, recent studies showed that resiniferatoxin (RTX) had anti-inflammatory activity, which decreased the serum levels of IL-12, INF-γ, IL-1β, TNF-α, NO, and PGE2, as well the number of eosinophils in the blood, associated with decreased intestinal pathology and muscle parasite burden. These researches demonstrate that RTX is capable to inhibit the production of Th1 cytokines, contributing to the defense against T. spiralis infection, which places it as a new potential drug modulator of the immune response.

참고문헌 (123)

  1. Grencis RK, "Immunity to gastrointestinal nematodes: mechanisms and myths", Immunol Rev, 260, pp.183~205 (2014)
  2. McSorley HJ, "Helminth infections and host immune regulation", Clin Microbiol Rev, 25, pp.585~608 (2012)
  3. Maizels RM, "Susceptibility and immunity to helminth parasites", Curr Opin Immunol, 24, pp.459~466 (2012)
  4. Zaph C, "Mucosal immune responses following intestinal nematode infection", Parasite Immunol, 36, pp.439~452 (2014)
  5. Elliott DE, "Helminths as governors of immune-mediated inflammation", Int J Parasitol, 37, pp.457~464 (2007)
  6. Maizels RM, "Immune regulation by helminth parasites: cellular and molecular mechanisms", Nat Rev Immunol, 3, pp.733~744 (2003)
  7. Bruschi F, "Immunomodulation in trichinellosis:does Trichinella really ecape the host immune system?", Endocr Metab Immune Disord Drug Targets, 12, pp.4~15 (2012)
  8. Laverde LM, "Detección de Trichinella spiralis en cerdos faenados en dos plantas de beneficio en el municipio de bello", Revista CES. Medicina Veterinariay Zootecnia, 4, pp.47~56 (2009)
  9. Bruschi F, "Trichinellosis in developing countries: is it neglected?", J Infect Dev Ctries, 6, pp.216~222 (2012)
  10. Pozio E, "World distribution of Trichinella spp. infections in animals and humans", Vet Parasitol, 149, pp.3~21 (2007)
  11. Krivokapich SJ, "Trichinella patagoniensis n. sp. (Nematoda), a new encapsulated species infecting carnivorous mammals in South America", Int J Parasitol, 42, pp.903~910 (2012)
  12. Pozio E, "New pieces of the Trichinella puzzle", Int J Parasitol, 43, pp.983~997 (2013)
  13. Bruschi F, "New aspects of human trichinellosis : the impact of new Trichinella species", Postgrad Med J, 78, pp.15~22 (2002)
  14. Murrell KD, "The dynamics of Trichinella spiralis epidemiology:out to pasture?", Vet Parasitol, 231, pp.92~96 (2016)
  15. Theodoropoulos G, "Trichinella spiralis: differential effect of host bile on the in vitro invasion of infective larvae into epithelial cells", Exp Parasitol, 126, pp.441~444 (2010)
  16. Moreno García MA, "Fase Intestinal de Trichinella spiralis en modelo murino", Acta biol Colomb, 14, pp.203~210 (2009)
  17. Moreno AG, "Elestudio de Trichinella spiralis en modelos experimentales", REDVET, 13, pp.1~12 (2012)
  18. Wu Z, "Trichinella spiralis : nurse cell formation with emphasis on analogy to muscle cell repair", Parasit Vectors, 1, pp.1~27 (2008)
  19. Gruden-Movsesijan A, "The impact of Trichinella spiralis excretory-secretory products on dendritic cells", Comp Immunol Microbiol Infect Dis, 34, pp.429~439 (2011)
  20. Ortega-Pierres MG, "Workshop on a detailed characterization of Trichinella spiralis antigens : a platform for future studies on antigens and antibodies to this parasite", Parasite Immunol, 6, pp.273~284 (1996)
  21. Appleton JA, "A pivotal role for glycans at the interface between Trichinella spiralis and its host", Vet Parasitol, 101, pp.249~260 (2001)
  22. Yépez-Mulia L, "Contributions to the study of Trichinella spiralis TSL-1antigens in host immunity", Parasite Immunol, 29, pp.661~670 (2007)
  23. Bolás-Fernandez F, "TSL-1 antigens of Trichinella:an overview of their potential role in parasite invasion, survival and serodiagnosis of trichinellosis", Res Vet Sci, 81, pp.297~303 (2006)
  24. Reason AJ, "Novel tyvelose-containing tri-and tetra-antennary N-glycans in the immunodominant antigens of the intracellular parasite Trichinella spiralis", Glycobiology, 5, pp.593~603 (1994)
  25. Nagano I, "Functional genes and proteins of Trichinella spp", Parasitol Res, 104, pp.197~207 (2009)
  26. Gold AM, "Partial characterization of two antigens secreted by L1 larvae of Trichinella spiralis", Mol Biochem Parasitol, 41, pp.187~196 (1990)
  27. Su XZ, "Cloning and expression of complementary DNA encoding an antigen of Trichinella spiralis", Mol Biochem Parasitol, 45, pp.331~336 (1991)
  28. Wu Z, "Expression of excretory and secretory protein genes of Trichinella at muscle stage differs before and after cyst formation", Parasitol Int, 51, pp.155~161 (2002)
  29. Mitreva M, "Gene discovery in the adenophorean nematode Trichinella spiralis : an analysis of transcription from three life cycle stages", Mol Biochem Parasitol, 137, pp.277~291 (2004)
  30. Zarlenga DS, "Molecular cloning and expression of an immunodominant 53-kDa excretory-secretory antigen from Trichinella spiralis muscle larvae", Mol Biochem Parasitol, 42, pp.165~174 (1990)
  31. Zarlenga DS, "Molecular cloning and expression of an immunodominant 53-kDa excretory-secretory antigen from Trichinella spiralis muscle larvae", Mol Biochem Parasitol, 72, pp.253~ (1995)
  32. Romarís F, "Monoclonal antibodies raised in Btk (xid) mice reveal new antigenic relationships and molecular interactions among gp53 and other Trichinella glycoproteins", Mol Biochem Parasitol, 125, pp.173~183 (2002)
  33. Arasu P, "Molecularanalysis of antigens targeted by protective antibodies in rapid expulsion of Trichinella spiralis", Mol Biochem Parasitol, 65, pp.201~211 (1994)
  34. Beiting DP, "Coordinated control of immunity to muscle stage Trichinella spiralis by IL-10, regulatory T Cells, and TGF-b", J Immunol, 178, pp.1039~1047 (2007)
  35. Ilic N, "Trichinella spiralis : shaping the immune response", Immunol Res, 52, pp.111~119 (2012)
  36. Ashour DS, "Trichinella spiralis immunomodulation : an interactive multifactorial process", Expert Rev Clin Immunol, 7, pp.669~675 (2013)
  37. Cieza RJ, "Immunomodulation for gastrointestinal infections", Expert Rev Anti Infect Ther, 3, pp.391~400 (2012)
  38. Koenderman L, "The innate immune response", Immunol Lett, 162, pp.95~102 (2014)
  39. Sher A, "Shaping the immune response to parasites : role of dendritic cells", Curr Opin Immunol, 4, pp.421~429 (2003)
  40. Ilic N, "Trichinella spiralis antigens prime mixed Th1", Th2 response but do not induce de novo generation of Foxp3? T cells in vitro, 2011, pp.33, 572~582
  41. Sofronic-Milosavljevic L, "Gruden-Movsesijan A. Secretory products of Trichinella spiralis muscle larvae and immunomodulation:implication for autoimmune diseases, allergies, and malignancies", J Immunol Res, 31, pp.523875~ (2015)
  42. Yu YR, "Systemic cytokine profiles and splenic toll-like receptor expression during Trichinella spiralis infection", Exp Parasitol, 134, pp.92~101 (2013)
  43. Gentilini MV, "Trichinella spiralis infection rapidly induces lung inflammatory response : the lung as the site of helminthocytotoxic activity", Immunobiology, 216, pp.1054~1063 (2011)
  44. Ilic N, "Characterization of rat bone marrow dendritic cells initially primed by Trichinella spiralis antigens", Parasite Immunol, 30, pp.491~ (2008)
  45. Ming L, "Invasion by Trichinella spiralis infective larvae affects the levels of inflammatory cytokines in intestinal epithelial cells in vitro", Exp Parasitol, 170, pp.220~226 (2016)
  46. Teng MW, "IL-12 and IL-23 cytokines : from discovery to targeted therapies for immune-mediated inflammatory diseases", Nat Med, 21, pp.719~729 (2015)
  47. BarbuleacuK B, "IL-12 and IL-18 differentially regulate the transcriptional activity of the human IFN-γ promoter in primary CD4+ T lymphocytes", J Immunol, 160, pp.3642~3647 (1998)
  48. Bogdan C, "Production of interferon-γ by myeloid cells-fact or fancy?", Trends Immunol, 27, pp.282~290 (2006)
  49. Pestka S, "Interferons, interferon-like cytokines, and their receptors", Immunol Rev, 202, pp.8~32 (2004)
  50. Mühl H, "Anti-inflammatory properties of pro-inflammatory interferon-γ", Int Immunopharmacol, 3(9), pp.1247~1255 (2003)
  51. Neumann B, "Distinct functions of interferon-gamma for chemokine expression in models of acute lung inflammation", Immunology, 95, pp.512~521 (1998)
  52. Helmby H, "IFN-γ-independent effects of IL-12during intestinal nematode infection", J Immunol, 171, pp.3691~3696 (2003)
  53. Leung L, "TNF-α and neuropathic pain-a review", J Neuroinflammation, 7, pp.27~ (2010)
  54. Horiuchi T, "Transmembrane TNF-α:structure, function and interaction with anti-TNF agents", Rheumatology (Oxford), 49, pp.1215~1228 (2010)
  55. Parameswaran N, "Tumor necrosis factor-α signaling in macrophages", Crit Rev Eukaryot Gene Expr, 20, pp.87~103 (2010)
  56. Lawrence CE, "IL-4-regulated enteropathy in an intestinal nematode infection", Eur J Immunol, 28, pp.2672~2684 (1998)
  57. Ierna MX, "Mast cell production of IL-4 and TNF may be required for protective and pathological responses in gastrointestinal helminth infection", Mucosal Immunol, 1, pp.147~155 (2008)
  58. Ierna MX, "Transmembrane tumor necrosis factor alpha is required for enteropathy and is sufficient to promote parasite expulsion in gastrointestinal helminth infection", Infect Immun, 77, pp.3879~3885 (2009)
  59. Bogdan C, "Nitric oxide and the immune response", Nat Immunol, 2, pp.907~916 (2001)
  60. Guzik TJ, "Nitric oxide and superoxide in inflammation and immune regulation", J Physiol Pharmacol, 54, pp.469~487 (2003)
  61. Marzocco S, "Effect of methylguanidine in carrageenan-induced acute inflammation in the rats", Eur J Pharmacol, 484, pp.341~350 (2004)
  62. Wink DA, "Nitric oxide and redox mechanisms in the immune response", J Leukoc Biol, 89, pp.873~891 (2011)
  63. Moncada S, "Does nitric oxide modulate mitochondrial energy generation and apoptosis?", Nat Rev Mol Cell Biol, 3, pp.214~220 (2002)
  64. Andrade MA, "Trichinella : differing effects of antigens from encapsulated and non-encapsulated species on in vitro nitric oxide production", Vet Parasitol, 143, pp.86~90 (2007)
  65. Lawrence CE, "Nitric oxide mediates intestinal pathology but not immune expulsion during Trichinella spiralis infection in mice", J Immunol, 164, pp.4229~4234 (2000)
  66. Dinarello CA, "Immunological and inflammatory functions of the interleukin-1 family", Annu Rev Immunol, 27, pp.519~550 (2009)
  67. Garib FY, "Inactivation of inflammasomes by pathogens regulates inflammation", Biochemistry (Mosc), 81, pp.1326~1339 (2016)
  68. Muñoz-Carrillo JL, "Resiniferatoxin lowers TNF-α, NO and PGE2 in the intestinal phase and the parasite burden in the muscular phase of T. spiralis infection", Parasite Immunol, 39, pp.1~14 (2017)
  69. Muñoz-Carrillo JL, "Resiniferatoxin modulates the Th1 immune response and protects the host during intestinal nematode infection", Parasite Immunol, 39, pp.1~16 (2017)
  70. Sofronic-Milosavljevic LJ, "Application of dendritic cells stimulated with Trichinella spiralis excretory-secretory antigens alleviates experimental autoimmune encephalomyelitis", Med Microbiol Immunol, 202, pp.239~249 (2013)
  71. Helmby H, "Contrasting roles for IL-10 in protective immunity to different life cycle stages of intestinal nematode parasites", Eur J Immunol, 33, pp.2382~2390 (2003)
  72. Gurish MF, "IgE enhances parasite clearance and regulates mast cell responses in mice infected with Trichinella spiralis", J Immunol, 172, pp.1139~1145 (2004)
  73. Wang LJ, "Helminth infections and intestinal inflammation", World J Gastroenterol, 14, pp.5125~5132 (2008)
  74. Rogerio AP, "Role of Leukotrienes on Protozoan and Helminth Infections", Mediators Inflamm, 2012, pp.595694~ (2012)
  75. Knight PA, "Innate immune response mechanisms in the intestinal epithelium : potential roles for mast cells and goblet cells in the expulsion of adult Trichinella spiralis", Parasitology, 135, pp.655~670 (2008)
  76. Akiho H, "Cytokine-induced alterations of gastrointestinal motility in gastrointestinal disorders", World J Gastrointest Pathophysiol, 2, pp.72~81 (2011)
  77. Rothenberg ME, "The eosinophil. Annual review of immunology", Annu Rev Immunol, 24, pp.147~174 (2006)
  78. Bruschi F, "Eosinophils and Trichinella infection: toxic for the parasite and the host?", Trends Parasitol, 24, pp.462~467 (2008)
  79. Vallance BA, "Interleukin-5 deficient mice exhibit impaired host defence against challenge Trichinella spiralis infections", Parasite Immunol, 22, pp.487~492 (2000)
  80. Gottstein B, "Epidemiology, diagnosis, treatment, and control of Trichinellosis", Clin Microbiol Rev, 22, pp.127~145 (2009)
  81. Dupouy-Camet J, "Opinion on the diagnosis and treatment of human trichinellosis", Expert Opin Pharmacother, 3, pp.1117~1130 (2002)
  82. Shimoni Z, "The use of prednisone in the treatment of trichinellosis", Isr Med Assoc J, 9, pp.537~539 (2007)
  83. Oakley RH, "Cellular processing of the glucocorticoid receptor gene and protein: new mechanisms for generating tissue-specific actions of glucocorticoids", J Biol Chem, 286, pp.3177~3184 (2011)
  84. Biddie SC, "Dynamic regulation of glucocorticoid signaling in health and disease", Rheumatology, 51, pp.403~412 (2012)
  85. Nixon M, "5α-Reduced glucocorticoids : a story of natural selection", J Endocrinol, 212, pp.111~127 (2012)
  86. Serra HA, "Glucocorticoides: paradigma de medicina traslacional. De lo molecular al uso clínico", Medicina, 72, pp.158~170 (2012)
  87. Charmandari E, "Primary generalized glucocorticoid resistance and hypersensitivity", Horm Res Paediatr, 76, pp.145~155 (2011)
  88. Saklatvala Jeremy, "Glucocorticoids: do we know how they work?", Arthritis Res, 4, pp.146~150 (2002)
  89. De Iudicibus S, "Molecular mechanism of glucocorticoid resistance in inflammatory bowel disease", World J Gastroenterol, 17, pp.1095~1108 (2011)
  90. Barnes PJ, "Glucocorticosteroids : current and future directions", Br J Pharmacol, 163, pp.29~43 (2011)
  91. Barnes PJ, "How corticosteroids control inflammation", Br J Pharmacol, 148, pp.245~254 (2006)
  92. Dostert A, "Negative glucocorticoid receptor response elements and their role in glucocorticoid action", Curr Pharm Des, 10, pp.2807~2816 (2004)
  93. Belvisi MG, "Regulation of inflammatory cell function by corticosteroids", Proc Am Thorac Soc, 1, pp.207~214 (2004)
  94. Wullaert A, "NF-κB in the regulation of epithelial homeostasis and inflammation", Cell Res, 21, pp.146~158 (2011)
  95. Ray A, "Physical association and functional antagonism between the p65 subunit of transcription factor NFkappa B and the glucocorticoid receptor", Proc Natl Acad Sci USA, 91, pp.752~756 (1994)
  96. Scheinman RI, "Characterization of mechanisms involved in transrepression of NF-kappa B by activated glucocorticoid receptors", Mol Cell Biol, 15, pp.943~953 (1995)
  97. Flammer JR, "Minireview : Glucocorticoids in autoimmunity : unexpected targets and mechanisms", Mol Endocrinol, 25, pp.1075~1086 (2011)
  98. Galon J, "Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells", FASEB J, 16, pp.61~71 (2002)
  99. Ashwell JD, "Glucocorticoids in T cell development and function", Annu Rev Immunol, 18, pp.309~345 (2000)
  100. Lasa M, "Dexamethasone destabilizes cyclooxygenase 2 mRNA by inhibiting mitogen-activated protein kinase p38", Mol Cell Biol, 21, pp.771~780 (2001)
  101. Lamas AM, "Glucocorticoids inhibit eosinophil responses to granulocyte-macrophage colony-stimulating factor", J Immunol, 147, pp.254~259 (1991)
  102. Arai Y, "Glucocorticoid-induced apoptotic pathways in eosinophils : comparison with glucocorticoid-sensitive leukemia cells", Int J Hematol, 71, pp.340~349 (2000)
  103. Bozic F, "Dexamethasone as a modulator of jejunal goblet cells hyperplasia during Trichinella spiralis gut infection of mice", Helminthologia, 37, pp.3~8 (2000)
  104. Alvarado RM, "Hormonal effect on the parasite load in the infection by T. spiralis of a murine experimental model. Trichinellosis", 9th International Conference on Trichinellosis (ICT9), pp.107~114 (1996)
  105. Piekarska J, "The effect of immunomodulating drugs on the percentage of apoptotic and necrotic lymphocytes in inflammatory infiltrations in the muscle tissue of mice infected with Trichinella spiralis", Pol J Vet Sci, 13, pp.233~240 (2010)
  106. Salazar H, "El canal TRPV1como diana para tratar el dolor", Rev Neurol, 48, pp.357~364 (2009)
  107. Pal M, "Vanilloid receptor antagonists : emerging class of novel anti-inflammatory agents for pain management", Curr Pharm Des, 15, pp.1008~1026 (2009)
  108. Nilius B, "Transient receptor potential channels as drug targets : from the science of basic research to the art of medicine", Pharmacol Rev, 66, pp.676~814 (2014)
  109. Carnevale V, "TRPV1 : a target for rational drug design", Pharmaceuticals (Basel), 9, pp.52~ (2016)
  110. 이영희, "Vanilloid Receptor 1 Agonists, Capsaicin and Resiniferatoxin, Enhance MHC Class I-restricted Viral Antigen Presentation in Virus-infected Dendritic Cells", Immune Network, 16(4), pp.233~241 (2016), 대한면역학회[DOI]
  111. Singh S, "Capsaicin(8-methyl-Nvanillyl-6-nonenamide)is a potent inhibitor of nuclear transcription factor-kappa B activation by diverse agents", J Immunol, 157, pp.4412~4420 (1996)
  112. Chen CW, "Signal transduction for inhibition of inducible nitric oxide synthase and cyclooxygenase-2 induction by capsaicin and related analogs in macrophages", Br J Pharmacol, 140, pp.1077~1087 (2003)
  113. Ueda K, "Preventive effect of TRPV1 agonists capsaicin and resiniferatoxin on ischemia", reperfusion-induced renal injury in rats, 2008, pp.51, 513~520
  114. Gutiérrez-Coronado Oscar, "Evaluación de la actividad antiinflamatoria de resiniferatoxina en un modelo murino de inflamación inducido por Lipopolicacárido", Rev. Latinoamer. Quím, 39, pp.287~ (2012)
  115. Levi-Schaffer F, "Mast Cells Enhance Eosinophil Survival In Vitro : Role of TNF-αand Granulocyte-Macrophage Colony-Stimulating", Factor J Immunol, 160, pp.5554~5562 (1998)
  116. Uings I, "Effects of dexamethasone on TNF-alpha-induced release of cytokines from purified human blood eosinophils", Clin Mol Allergy, 3, pp.1~5 (2005)
  117. Hebestreit H, "Expression and function of the Fas receptor on human blood and tissue eosinophils", Eur J Immunol, 26, pp.1775~1780 (1996)
  118. Létuvé S, "Involvement of caspases and of mitochondria in Fas ligationinduced eosinophil apoptosis : modulation by interleukin-5and interferon-gamma", J Leukoc Biol, 70, pp.767~775 (2001)
  119. Hebestreit H, "Disruption of Fas Receptor Signaling by Nitric Oxide in Eosinophils", J Exp Med, 187, pp.415~425 (1998)
  120. Fabre V, "Eosinophil deficiency compromises parasite survival in chronic nematode infection", J Immunol, 182, pp.1577~1583 (2009)
  121. Huang L, "Eosinophil-derived IL-10 supports chronic nematode infection", J Immunol, 193, pp.4178~4187 (2014)
  122. Huang L, "Eosinophils mediate protective immunity against secondary nematode infection", J Immunol, 194, pp.283~290 (2015)
  123. Huang L, "Eosinophils and IL-4 support nematode growth coincident with an innate response to tissue injury", PLoS Pathog, 11, pp.1~17 (2015)

관련 논문AI추천

Protease-Activated Receptor 2 Is Involved in Th2 Responses against Trichinella spiralis Infection강신애, 김기욱, 김동희, 김윤성, 박미경, 박혜경, 안순철, 유학선, 조민경대한기생충학ㆍ열대의학회 · Parasites, Hosts and Diseases2011 · 제49권 제3호Trichinella spiralis Infection Suppressed Gut Inflammation with $CD4^+CD25^+Foxp3^+$ T Cell Recruitment박미경, 안순철, 유학선, 조민경, Seon Hee Choi, Shin Ae Kang대한기생충학ㆍ열대의학회 · Parasites, Hosts and Diseases2012 · 제50권 제4호Therapeutic potentials of Trichinella spiralis in immune disorders: From allergy to autoimmunity유학선, Cho Minkyoung대한기생충학ㆍ열대의학회 · Parasites, Hosts and Diseases2025 · 제63권 제2호Immune Correlates of Resistance to Trichinella spiralis Reinfection in Mice이동훈, Ah-Ra Kim, Fu-Shi Quan, Ki-Back Chu, Sang-Soo Kim, Su-Hwa Lee대한기생충학ㆍ열대의학회 · Parasites, Hosts and Diseases2016 · 제54권 제5호Toll-Like Receptor Gene Expression during Trichinella spiralis Infection박미경, 유학선, Sin Kim대한기생충학ㆍ열대의학회 · Parasites, Hosts and Diseases2015 · 제53권 제4호Activation and Recruitment of Regulatory T Cells via Chemokine Receptor Activation in Trichinella spiralis-Infected MiceDongHeeKim, Hak Sun Yu, Jeong-Bin Ahn, Shin Ae Kang대한기생충학ㆍ열대의학회 · Parasites, Hosts and Diseases2016 · 제54권 제2호

이 간행물의 다른 논문 (12건)

Genotypic Identification of Cystoisospora in Immunocompromised Patients Using Tm-Variation AnalysisMaha M.A. Basyoni, Hany Ahmed Fouad Elghobarypp. 601-606Comparison of Placenta PCR and Maternal Serology of Aborted Women for Detection of Toxoplasma gondii in Ardabil, IranSomaie Matin, Hadi Piri-dogahe, Rouhallah Moradpour, Shervin Tabrizian Namin, Gholamreza Shahbazipp. 607-611IL-12 and IL-23 Production in Toxoplasma gondii- or LPS- Treated Jurkat T Cells via PI3K and MAPK Signaling Pathways이재형, 차광호, 김재수, 최인욱, 이영하, 강병훈, 육재민, Hassan Ahmed Hassan Ahmed Ismailpp. 613-622Development of Monoclonal Antibodies for Diagnosis of Plasmodium vivaxDong-Xu Liu, Nguyen Thi Phuong Linh, 한은택, 신호준, 여선주, 손혜진, 이진영, 한진희, 박현, 서가은pp. 623-630Zoonotic Trematode Metacercariae in Fish from Yangon, Myanmar and Their Adults Recovered from Experimental AnimalsHtay Htay Tin, 홍의혁, Thi Thi Htoon, 나병국, 채종일, 박종복, 손운목, 정후근pp. 631-641
원문 보기