본문 바로가기
KERD
논문KCI 등재

ider(9)(q10)t(9;22)(q34;q11.2)가 동반된 급성림프구성백혈병 1예

A Case of Acute Lymphoblastic Leukemia with ider(9)(q10)t(9;22)(q34;q11.2)

2

조회

0

다운로드

1

인용

0

참고문헌

주제분류병리학

초록

ider(9)(q10)t(9;22) 염색체 이상은 t(9;22) 염색체 이상에 의해 생성된 der(9)t(9;22)의 9번 염색체 단완이 결실되고 장완은등완염색체 모양으로 장완 중복이 있는 형태인데, 만성골수구성백혈병의 림프구성 모세포 발증기 또는 급성림프구성백혈병에서 드물게 관찰되는 염색체 이상이다. 저자들은 B 세포 급성림프구성백혈병으로 진단받는 26세 여자 환자에서 ider(9)(q10)t(9;22) 염색체 이상이 관찰되었던 증례를 경험하였다. 형광동소교잡법 결과는 der(9) 염색체에 ABL-BCR 융합신호가 2개, der(22) 염색체에 BCR-ABL 융합 신호가 1개 관찰되었다. 급성림프구성백혈병환자에서 t(9;22)와 9번 염색체 단완의 결실이 있을 경우 불량한예후와 연관이 있는 것으로 알려져 있는데, ider(9)(q10)t(9;22)염색체 이상과 예후와의 연관성을 알아보기 위해 더 많은 환자들을 대상으로 추후 연구가 필요하다.

참고문헌 (18)

  1. "Philadelphia chro-mosome-positive leukemias:from basic mechanisms to moleculartherapeutics", 138, pp.819~830 (2003)
  2. "ider(9)(q10)t(9;22)(q34;q11) is a recurrent chromosomal abnor-mality in acute lymphoblastic leukemia and lymphatic blastic phaseof chronic myelogenous leukemia", 89, pp.109~113 (1996)
  3. "Possible cytogenetic distinc-tionbetween lymphoid and myeloid blast crisis in chronic granulo-cytic leukemia", 27, pp.194~203 (1988)
  4. "Cyto-geneticanalysis of hematologic malignancies in Hong Kong.A studyof 98 cases", 62, pp.154~9 (1992)
  5. "Involvement of the short arm of the derivative chromosome 9 inPhiladelphia-positive acute lymphoblastic leukemia", 52, pp.43~9 (1991)
  6. "Cytogeneticanalysis in relapsed childhood acute lymphoblastic leukemia", 6, pp.185~92 (1992)
  7. "ider(9)(q10)(q34;q11.2) as secondary karyotypic aberration of chronic myeloidleukemia", 19, pp.266~270 (1999)
  8. "Prognostic significance of additional chromosomeabnormalities in adult patients with Philadelphia chromosome positive acute lymphoblastic leukaemia", 95, pp.678~691 (1996)
  9. "An Internationa System for Human Cytogenetic Nomenclature" (2005), S. Karger
  10. "Secondary cytogenetic aberrations in childhoodPhiladelphia chromosome positive acute lymphoblastic leukemia are nonrandom and may be associated with outcome", 18, pp.693~702 (2004)
  11. "Additional cytogenetic abnormalities in adults with Philadelphiachromosome-positive acute lymphoblastic leukaemia:a study of the Cancer and Leukaemia Group B", 124, pp.275~288 (2004)
  12. "Additional clonal abnormalities in Philadelphia-positive ALL andCML demonstrate a different cytogenetic pattern at diagnosis and follow different pathways at progression", 157, pp.53~61 (2005)
  13. "The incidence of chromosome 9p21 abnormalities and deletionsof tumor suppressor genes p15(INK4b)", p16(INK4a), pp.1999, 5[DOI]
  14. "FISH analysis of translocations involving the short arm of chromosome9 in lymphoid malignancies", 19, pp.273~277 (1997)
  15. "BCR-ABL gene amplification and overexpression in a patientwith chronic myeloid leukemia treated with imatinib", 159, pp.164~167 (2005)
  16. "Amplification of the BCR", ABL fusion gene clustered on a masked Philadelphiachromosome in a patient with myeloblastic crisis of chronic myelocytic leukemia, 2003, pp.143, 140~144
  17. "ABL1 amplification in T-cell acute lymphoblasticleukemia", 162, pp.146~150 (2005)
  18. "ABL oncogene amplification with p16(INK4a) gene deletion in precursor T-cell acute lymphoblasticleukemia", lymphoma: report of the first case, 2004, pp.76, 360~363

관련 논문AI추천

이 간행물의 다른 논문 (5건)