Validity of Korean Versions of the Multiple Sclerosis Impact Scale and the Multiple Sclerosis International Quality of Life Questionnaire
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Background and Purpose Assessment of the health-related quality of life (HRQoL) is important in clinical evaluations of multiple sclerosis (MS) patients for quantifying the impact ofillness and treatment on their daily lives. Although MS-specific HRQoL instruments have beenused internationally, there are no data regarding HRQoL instruments specifically designed forpatients with MS in Korea. The objective of this study was to determine the reliability and validity of the Korean Multiple Sclerosis Impact Scale (MSIS-29) and the Multiple Sclerosis International Quality of Life (MusiQoL) questionnaire. Methods Fifty-six patients with MS were recruited from June 2009 to February 2010 at theNational Cancer Center in Korea. The original English versions of the MSIS-29 scale and theMusiQoL questionnaire were translated into Korean and evaluated for their acceptability, reliability, and validity. Results The patients wereaged 36.5±8.6 years (mean±SD; range, 20–56 years). Their scoreon the Expanded Disability Status Scale was 2.0±1.9 (mean; range, 0–7.5), and their diseaseduration was 5.2±4.7 years (mean±SD; range, 1–24 years). The Korean versions of the MSIS29 and MusiQoL questionnaires showed satisfactory psychometric properties, including construct validity (item-internal consistencies of 0.59–0.95 and 0.59–0.92, respectively; item-discriminant validities of 95–100% and 93.8–100%), internal consistency (Cronbach’s alphacoefficients of 0.96–0.97 and 0.77–0.96), reliability (intraclass correlation coefficients of 0.78–0.90 and 0.50–0.93), unidimensionality (Loevinger scalability coefficients of 0.70–0.78 and0.63–0.90), and acceptability. External validity testing indicated the presence of significant correlations between similar aspects of the two questionnaires. Conclusions The Korean translated versions of the MSIS-29 and MusiQoL questionnairesdemonstrated reliability and validity for measuring HRQoL in Korean patients with MS.
Abstract
Background and Purpose Assessment of the health-related quality of life (HRQoL) is important in clinical evaluations of multiple sclerosis (MS) patients for quantifying the impact ofillness and treatment on their daily lives. Although MS-specific HRQoL instruments have beenused internationally, there are no data regarding HRQoL instruments specifically designed forpatients with MS in Korea. The objective of this study was to determine the reliability and validity of the Korean Multiple Sclerosis Impact Scale (MSIS-29) and the Multiple Sclerosis International Quality of Life (MusiQoL) questionnaire. Methods Fifty-six patients with MS were recruited from June 2009 to February 2010 at theNational Cancer Center in Korea. The original English versions of the MSIS-29 scale and theMusiQoL questionnaire were translated into Korean and evaluated for their acceptability, reliability, and validity. Results The patients wereaged 36.5±8.6 years (mean±SD; range, 20–56 years). Their scoreon the Expanded Disability Status Scale was 2.0±1.9 (mean; range, 0–7.5), and their diseaseduration was 5.2±4.7 years (mean±SD; range, 1–24 years). The Korean versions of the MSIS29 and MusiQoL questionnaires showed satisfactory psychometric properties, including construct validity (item-internal consistencies of 0.59–0.95 and 0.59–0.92, respectively; item-discriminant validities of 95–100% and 93.8–100%), internal consistency (Cronbach’s alphacoefficients of 0.96–0.97 and 0.77–0.96), reliability (intraclass correlation coefficients of 0.78–0.90 and 0.50–0.93), unidimensionality (Loevinger scalability coefficients of 0.70–0.78 and0.63–0.90), and acceptability. External validity testing indicated the presence of significant correlations between similar aspects of the two questionnaires. Conclusions The Korean translated versions of the MSIS-29 and MusiQoL questionnairesdemonstrated reliability and validity for measuring HRQoL in Korean patients with MS.
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