Comparison of the Efficacies of Silver-Containing Dressing Materials for Treating a Full-Thickness Rodent Wound Infected by Methicillin-resistant Staphylococcus aureus
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Background : Methicillin-resistant Staphylococcus aureus (MRSA) may cause infections during wound dressing. We aimed to compare the antibacterial activities and wound-healing effects of commercially available silver-coated or silver-impregnated wound dressings on MRSA-infected wounds. Methods : Full-thickness skin defects were made on the back of rats (N=108) and were infected with MRSA. The rats were divided into the following 6 groups according to the dressing used for the wounds: nanocrystalline silver (Acticoat), silver carboxymethylcellulose (Aquacel-Ag), silver sulfadiazine (Medifoam silver), nanocrystalline silver (PolyMem silver), silver sulfadiazine (Ilvadon), and 10% povidone iodide (Betadine). We analyzed the wound sizes, histological findings, and bacterial colony counts for the groups. We also inoculated the silver materials on Mueller-Hinton agar plates containing MRSA and compared the inhibition zones in the agar plates. Results : The order of the rate of wound-size decrease was Acticoat>Aquacel-Ag>PolyMem silver>Medifoam silver>Ilvadon>Betadine. The histological findings revealed that the Acticoat showed more reepithelialization and granulation tissue formation and less inflammatory cell infiltration than the other materials. The order of the time required for wound healing was Acticoat>Aquacel -Ag>PolyMem silver>Ilvadon>Medifoam silver>Betadine. The bacterial colony counts reduced in all the groups, except in the Medifoam silver group. The order of the size of the inhibition zone was Acticoat>Aquacel-Ag>Ilvadon>PolyMem silver>Betadine>Medifoam silver. Conclusions : Silver-coated or silver-impregnated wound dressings can be used for treating MRSAinfected wounds. Considering its superior efficacy in comparison to the efficacies of other silver-coated or silver-impregnated wound dressings, Acticoat should be preferentially used for the treatment of MRSA-infected skin wounds. (Korean J Lab Med 2010;30:20-7)
Abstract
Background : Methicillin-resistant Staphylococcus aureus (MRSA) may cause infections during wound dressing. We aimed to compare the antibacterial activities and wound-healing effects of commercially available silver-coated or silver-impregnated wound dressings on MRSA-infected wounds. Methods : Full-thickness skin defects were made on the back of rats (N=108) and were infected with MRSA. The rats were divided into the following 6 groups according to the dressing used for the wounds: nanocrystalline silver (Acticoat), silver carboxymethylcellulose (Aquacel-Ag), silver sulfadiazine (Medifoam silver), nanocrystalline silver (PolyMem silver), silver sulfadiazine (Ilvadon), and 10% povidone iodide (Betadine). We analyzed the wound sizes, histological findings, and bacterial colony counts for the groups. We also inoculated the silver materials on Mueller-Hinton agar plates containing MRSA and compared the inhibition zones in the agar plates. Results : The order of the rate of wound-size decrease was Acticoat>Aquacel-Ag>PolyMem silver>Medifoam silver>Ilvadon>Betadine. The histological findings revealed that the Acticoat showed more reepithelialization and granulation tissue formation and less inflammatory cell infiltration than the other materials. The order of the time required for wound healing was Acticoat>Aquacel -Ag>PolyMem silver>Ilvadon>Medifoam silver>Betadine. The bacterial colony counts reduced in all the groups, except in the Medifoam silver group. The order of the size of the inhibition zone was Acticoat>Aquacel-Ag>Ilvadon>PolyMem silver>Betadine>Medifoam silver. Conclusions : Silver-coated or silver-impregnated wound dressings can be used for treating MRSAinfected wounds. Considering its superior efficacy in comparison to the efficacies of other silver-coated or silver-impregnated wound dressings, Acticoat should be preferentially used for the treatment of MRSA-infected skin wounds. (Korean J Lab Med 2010;30:20-7)
참고문헌 (24)
- Kim HB, "In vitro activities of 28 antimicrobial agents against Staphylococcus aureus isolates from tertiary-care hospitals in Korea: a nationwide survey", Antimicrob Agents Chemother, 48, pp.1124~1127 (2004)
- Hernandez R, "The use of systemic antibiotics in the treatment of chronic wounds", Dermatol Ther, 19, pp.326~337 (2006)
- Attinger CE, "Clinical approach to wounds: debridement and wound bed preparation including the use of dressings and wound-healing adjuvants", Plast Reconstr Surg, 117(S7), pp.S72~S109 (2006)
- 정태광, "다제내성(多劑耐性)을 지닌 균주에 감염된 상처에서 Nanocrystalline Silver(Acticoat？) 드레싱의 효용", Archives of Plastic Surgery, 34(6), pp.691~696 (2007), 대한성형외과학회
- Lowy FD, "Staphylococcus aureus infections", N Engl J Med, 339, pp.520~532 (1998)
- 김주형, "메치실린 저항 포도알균에 감염된 창상 치료에 있어 음압요법의 의의", Archives of Plastic Surgery, 33(5), pp.632~636 (2006), 대한성형외과학회
- Hartman BJ, "Low-affinity penicillin-binding protein associated with β-lactam resistance in Staphylococcus aureus", J Bacteriol, 158, pp.513~516 (1984)
- Lansdown AB, "A review of the use of silver in wound care: facts and fallacies", Br J Nurs, 13(S6), pp.S6~S19 (2004)
- Lansdown AB, "Silver in health care: antimicrobial effects and safety in use", Curr Probl Dermatol, 33, pp.17~34 (2006)
- Jones SA, "Controlling wound bioburden with a novel silver-containing Hydrofiber dressing", Wound Repair Regen, 12, pp.288~294 (2004)
- Bowler PG, "Microbicidal properties of a silver-containing Hydrofiber dressing against a variety of burn wound pathogens", J Burn Care Rehabil, 25, pp.192~196 (2004)
- Supp AP, "Evaluation of cytotoxicity and antimicrobial activity of Acticoat burn dressing for management of microbial contamination in cultured skin substitutes grafted to athymic mice", J Burn Care Rehabil, 26, pp.238~246 (2005)
- Dunn K, "The role of ActicoatTM with nanocrystalline silver in the management of burns", Burns, 30(S1), pp.S1~S9 (2004)
- Mooney EK, "Plastic surgery educational foundation DATA committee. Silver dressings", Plast Reconstr Surg, 117, pp.666~669 (2006)
- Weber RS, "A randomized prospective trial comparing a hydrophilic polyurethane absorbent foam dressing with a petrolatum gauze dressing", Arch Otolaryngol Head Neck Surg, 121, pp.1145~1149 (1995)
- Wells MD, "A new method of skin-graft stabilization:the reston technique", Ann Plast Surg, 34, pp.554~556 (1995)
- Salisbury RE, "A clinical and laboratory evaluation of a polyurethane foam: a new donor site dressing", Arch Surg, 114, pp.1188~1192 (1979)
- 하태순, "화상에서메디폼-실버(메디폼-S)의임상적유용성", 대한화상학회지, 10, pp.65~70 (2007)
- Atiyeh BS, "Effect of silver on burn wound infection control and healing: review of the literature", Burns, 33, pp.139~148 (2007)
- Caruso DM, "Randomized clinical study of Hydrofiber dressing with silver or silver sulfadiazine in the management of partial-thickness burns", J Burn Care Res, 27, pp.298~309 (2006)
- Parsons D, "Silver antimicrobial dressings in wound management: a comparison of antibacterial, physical, and chemical characteristics", Wounds, 17, pp.222~232 (2005)
- Catledge SA, "Nanostructured ceramics for biomedical implants", J Nanosci Nanotechnol, 2, pp.293~312 (2002)
- 채창훈, "은 나노 연고가 측두하악관절낭염의 환자의 치료에 미치는 영향에 관한 연구", 대한구강악안면외과학회지, 32(3), pp.262~266 (2006), 대한구강악안면외과학회
- Paddle-Ledinek JE, "Effect of different wound dressings on cell viability and proliferation", Plast Reconstr Surg, 117(S7), pp.S110~S118 (2006)