Asymmetric Gray Matter Volume Changes Associated with Epilepsy Duration and Seizure Frequency in Temporal-Lobe-Epilepsy Patients with Favorable Surgical Outcome
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Background and PurposezzTis study aimed to estimate the changes in gray matter volume (GMV) and their hemispheric diference in patients with mesial temporal lobe epilepsy (MTLE) using a voxel-based morphometry (VBM) methodology, and to determine whether GMV changes are correlated with clinical features. MethodszzVBM analysis of brain MRI using statistical parametric mapping 8 (SPM8) was performed for 30 lef MTLE (LMTLE) and 30 right MTLE (RMTLE) patients and 30 age- and sex-matched healthy controls. We also analyzed the correlations between GMV changes and clinical features of MTLE patients. ResultszzIn SPM8-based analyses, MTLE patients showed signifcant GMV reductions in the hippocampus ipsilateral to the epileptic focus, bilateral thalamus, and contralateral putamen in LMTLE patients. Te GMV reductions were more extensive in the ipsilateral hippocampus, thalamus, caudate, putamen, uncus, insula, inferior temporal gyrus, middle occipital gyrus, cerebellum, and paracentral lobule in RMTLE patients. Tese patients also exhibited notable reductions of GMV in the contralateral hippocampus, thalamus, caudate, putamen, and inferior frontal gyrus. We observed that GMV reduction was positively correlated with several clinical features (epilepsy duration and seizure frequency in RMTLE, and history of febrile seizure in LMTLE) and negatively correlated with seizure onset age in both the RM- TLE and LMTLE groups. ConclusionszzOur study revealed GMV decreases in the hippocampus and extrahippocampal regions. Furthermore, the GMV reduction was more extensive in the RMTLE group than in the LMTLE group, since it included the contralateral hemisphere in the former. Tis diference in the GMV reduction patterns between LMTLE and RMTLE may be related to a longer epilepsy duration and higher seizure frequency in the latter.
Abstract
Background and PurposezzTis study aimed to estimate the changes in gray matter volume (GMV) and their hemispheric diference in patients with mesial temporal lobe epilepsy (MTLE) using a voxel-based morphometry (VBM) methodology, and to determine whether GMV changes are correlated with clinical features. MethodszzVBM analysis of brain MRI using statistical parametric mapping 8 (SPM8) was performed for 30 lef MTLE (LMTLE) and 30 right MTLE (RMTLE) patients and 30 age- and sex-matched healthy controls. We also analyzed the correlations between GMV changes and clinical features of MTLE patients. ResultszzIn SPM8-based analyses, MTLE patients showed signifcant GMV reductions in the hippocampus ipsilateral to the epileptic focus, bilateral thalamus, and contralateral putamen in LMTLE patients. Te GMV reductions were more extensive in the ipsilateral hippocampus, thalamus, caudate, putamen, uncus, insula, inferior temporal gyrus, middle occipital gyrus, cerebellum, and paracentral lobule in RMTLE patients. Tese patients also exhibited notable reductions of GMV in the contralateral hippocampus, thalamus, caudate, putamen, and inferior frontal gyrus. We observed that GMV reduction was positively correlated with several clinical features (epilepsy duration and seizure frequency in RMTLE, and history of febrile seizure in LMTLE) and negatively correlated with seizure onset age in both the RM- TLE and LMTLE groups. ConclusionszzOur study revealed GMV decreases in the hippocampus and extrahippocampal regions. Furthermore, the GMV reduction was more extensive in the RMTLE group than in the LMTLE group, since it included the contralateral hemisphere in the former. Tis diference in the GMV reduction patterns between LMTLE and RMTLE may be related to a longer epilepsy duration and higher seizure frequency in the latter.
참고문헌 (36)
- 배은기, "Neuropathologic and Clinical Features of Human Medial Temporal Lobe Epilepsy", Journal of Clinical Neurology, 6(2), pp.73~80 (2010), 대한신경과학회
- Regesta G, "Clinical aspects and biological bases of drug-resistant epilepsies", Epilepsy Res, 34, pp.109~122 (1999)
- Keller SS, "Voxel-based morphometry of temporal lobe epilepsy: an introduction and review of the literature", Epilepsia, 49, pp.741~757 (2008)
- Bernasconi N, "Entorhinal cortex in temporal lobe epilepsy: a quantitative MRI study", Neurology, 52, pp.1870~1876 (1999)
- Bernasconi N, "Whole-brain voxel-based statistical analysis of gray matter and white matter in temporal lobe epilepsy", Neuroimage, 23, pp.717~723 (2004)
- Bonilha L, "Asymmetrical extra-hippocampal grey matter loss related to hippocampal atrophy in patients with medial temporal lobe epilepsy", J Neurol Neurosurg Psychiatry, 78, pp.286~294 (2007)
- Keller SS, "Comparison of standard and optimized voxel-based morphometry for analysis of brain changes associated with temporal lobe epilepsy", Neuroimage, 23, pp.860~868 (2004)
- Bonilha L, "Extrahippocampal gray matter loss and hippocampal deafferentation in patients with temporal lobe epilepsy", Epilepsia, 51, pp.519~528 (2010)
- Bonilha L, "Voxel-based morphometry reveals gray matter network atrophy in refractory medial temporal lobe epilepsy", Arch Neurol, 61, pp.1379~1384 (2004)
- Keller SS, "Voxel-based morphometric comparison of hippocampal and extrahippocampal abnormalities in patients with left and right hippocampal atrophy", Neuroimage, 16, pp.23~31 (2002)
- Pail M, "An optimized voxel-based morphometric study of gray matter changes in patients with left-sided and right-sided mesial temporal lobe epilepsy and hippocampal sclerosis (MTLE", HS), 2010, pp.51, 511~518
- Bonilha L, "Voxel-based morphometry of the thalamus in patients with refractory medial temporal lobe epilepsy", Neuroimage, 25, pp.1016~1021 (2005)
- Guye M, "The role of corticothalamic coupling in human temporal lobe epilepsy", Brain, 129, pp.1917~1928 (2006)
- Keller SS, "Persistent seizures following left temporal lobe surgery are associated with posterior and bilateral structural and functional brain abnormalities", Epilepsy Res, 74, pp.131~139 (2007)
- Mueller SG, "Voxel-based optimized morphometry (VBM) of gray and white matter in temporal lobe epilepsy (TLE) with and without mesial temporal sclerosis", Epilepsia, 47, pp.900~907 (2006)
- Nelissen N, "Correlations of interictal FDG-PET metabolism and ictal SPECT perfusion changes in human temporal lobe epilepsy with hippocampal sclerosis", Neuroimage, 32, pp.684~695 (2006)
- Ashburner J, "A fast diffeomorphic image registration algorithm", Neuroimage, 38, pp.95~113 (2007)
- Ashburner J, "Unified segmentation", Neuroimage, 26, pp.839~851 (2005)
- Ashburner J, "Voxel-based morphometry--the methods", Neuroimage, 11, pp.805~821 (2000)
- Jack CR Jr, "MRI-based hippocampal volumetrics: data acquisition, normal ranges, and optimal protocol", Magn Reson Imaging, 13, pp.1057~1064 (1995)
- Coan AC, "Seizure frequency and lateralization affect progression of atrophy in temporal lobe epilepsy", Neurology, 73, pp.834~842 (2009)
- Riederer F, "Network atrophy in temporal lobe epilepsy: a voxel-based morphometry study", Neurology, 71, pp.419~425 (2008)
- Li J, "A meta-analysis of voxel-based morphometry studies on unilateral refractory temporal lobe epilepsy", Epilepsy Res, 98, pp.97~103 (2012)
- Brázdil M, "Correlation study of optimized voxel-based morphometry and (1)HMRS in patients with mesial temporal lobe epilepsy and hippocampal sclerosis", Hum Brain Mapp, 30, pp.1226~1235 (2009)
- Scanlon C, "Grey and white matter abnormalities in temporal lobe epilepsy with and without mesial temporal sclerosis", J Neurol, 260, pp.2320~2329 (2013)
- Hetherington HP, "A subcortical network of dysfunction in TLE measured by magnetic resonance spectroscopy", Neurology, 69, pp.2256~2265 (2007)
- Mueller SG, "Involvement of the thalamocortical network in TLE with and without mesiotemporal sclerosis", Epilepsia, 51, pp.1436~1445 (2010)
- DeCarli C, "Extratemporal atrophy in patients with complex partial seizures of left temporal origin", Ann Neurol, 43, pp.41~45 (1998)
- Labate A, "Hippocampal and thalamic atrophy in mild temporal lobe epilepsy: a VBM study", Neurology, 71, pp.1094~1101 (2008)
- Bonilha L, "Gray matter atrophy associated with duration of temporal lobe epilepsy", Neuroimage, 32, pp.1070~1079 (2006)
- Dabbs K, "Brain structure and aging in chronic temporal lobe epilepsy", Epilepsia, 53, pp.1033~1043 (2012)
- Faeth WH, "The propagation of cortical and subcortical epileptic discharge", Epilepsia, 3, pp.37~48 (1954)
- Santana MT, "Auras and clinical features in temporal lobe epilepsy:a new approach on the basis of voxel-based morphometry", Epilepsy Res, 89, pp.327~338 (2010)
- Barbas H, "Connections underlying the synthesis of cognition, memory, and emotion in primate prefrontal cortices", Brain Res Bull, 52, pp.319~330 (2000)
- Hermann B, "Executive system dysfunction in temporal lobe epilepsy: effects of nociferous cortex versus hippocampal pathology", J Clin Exp Neuropsychol, 17, pp.809~819 (1995)
- Lieb JP, "Role of the frontal lobes in the propagation of mesial temporal lobe seizures", Epilepsia, 32, pp.822~837 (1991)