Central Nervous System Infection-Related Isolated Hippocampal Atrophy as Another Subtype of Medial Temporal Lobe Epilepsy with Hippocampal Atrophy: A Comparison to Conventional Medial Temporal Lobe Epilepsy with Hippocampal Atrophy
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Background and Purpose Hippocampal atrophy (HA) resulting from a central nervous system (CNS) infection might be a relevant lesion responsible for the clinical characteristics of medial temporal lobe epilepsy. Methods The clinical characteristics of 54 patients with CNS infection-related medial temporal lobe epilepsy (MTLE) with isolated HA (CNS infection group) and 155 patients with conventional MTLE with HA (conventional group) were compared retrospectively. CNS infection alone and bilateral involvement of the HA were analyzed as prognostic factors, in addition to the detailed clinical characteristics, such as limbic aura and the presence and proportion of each type of automatism, between the two groups, and both medical and surgical prognoses were separately considered. A logistic regression analysis was performed. Results A statistical analysis including all clinical factors, including CNS infection with bilateral HA, did not reveal significant differences between the two groups. An analysis comparing the prognosis of the two groups based on good or poor prognosis among patients who received medical treatment and good or poor outcomes among patients who received surgical treatment did not produce significant differences. Conclusions In addition to bilateral HA, CNS infection alone was not a poor prognostic factor for the CNS infection-related epilepsy with HA group compared with the conventional MTLE with HA group. Based on these negative results, HA is a plausible and relevant lesion with similar clinical characteristics to HA in patients with conventional MTLE. Therefore, CNS infection-related MTLE with isolated HA might represent another subtype of MTLE with HA with a different etiology.
Abstract
Background and Purpose Hippocampal atrophy (HA) resulting from a central nervous system (CNS) infection might be a relevant lesion responsible for the clinical characteristics of medial temporal lobe epilepsy. Methods The clinical characteristics of 54 patients with CNS infection-related medial temporal lobe epilepsy (MTLE) with isolated HA (CNS infection group) and 155 patients with conventional MTLE with HA (conventional group) were compared retrospectively. CNS infection alone and bilateral involvement of the HA were analyzed as prognostic factors, in addition to the detailed clinical characteristics, such as limbic aura and the presence and proportion of each type of automatism, between the two groups, and both medical and surgical prognoses were separately considered. A logistic regression analysis was performed. Results A statistical analysis including all clinical factors, including CNS infection with bilateral HA, did not reveal significant differences between the two groups. An analysis comparing the prognosis of the two groups based on good or poor prognosis among patients who received medical treatment and good or poor outcomes among patients who received surgical treatment did not produce significant differences. Conclusions In addition to bilateral HA, CNS infection alone was not a poor prognostic factor for the CNS infection-related epilepsy with HA group compared with the conventional MTLE with HA group. Based on these negative results, HA is a plausible and relevant lesion with similar clinical characteristics to HA in patients with conventional MTLE. Therefore, CNS infection-related MTLE with isolated HA might represent another subtype of MTLE with HA with a different etiology.
참고문헌 (50)
- Engle J, "Update on surgical treatment of the epilepsies: summary of the Second International Palm Desert Conference on the surgical treatment of the epilepsies (1992)", Neurology, 43, pp.1612~1617 (1993)
- Wieser HG, "ILAE Commission report. Mesial temporal lobe epilepsy with hippocampal sclerosis", Epilepsia, 45, pp.695~714 (2004)
- French JA, "Characteristics of medial temporal lobe epilepsy : I. Results of history and physical examination", Ann Neurol, 34, pp.774~780 (1993)
- Mathern GW, "The clinical-pathogenic mechanisms of hippocampal neuron loss and surgical outcomes in temporal lobe epilepsy", Brain, 118, pp.105~118 (1995)
- Cendes F, "Early childhood prolonged febrile convulsions, atrophy and sclerosis of mesial structures, and temporal lobe epilepsy : an MRI volumetric study", Neurology, 43, pp.1083~1087 (1993)
- Cendes F, "Atrophy of mesial structures in patients with temporal lobe epilepsy : cause or consequence of repeated seizures?", Ann Neurol, 34, pp.795~801 (1993)
- Kuks JB, "Hippocampal sclerosis in epilepsy and childhood febrile seizures", Lancet, 342, pp.1391~1394 (1993)
- Patterson KP, "Origins of temporal lobe epilepsy : febrile seizures and febrile status epilepticus", Neurotherapeutics, 11, pp.242~250 (2014)
- Lewis DV, "Hippocampal sclerosis after febrile status epilepticus : the FEBSTAT study", Ann Neurol, 75, pp.178~185 (2014)
- Shinnar S, "MRI abnormalities following febrile status epilepticus in children : the FEBSTAT study", Neurology, 79, pp.871~877 (2012)
- Auvin S, "Inflammation induced by LPS enhances epileptogenesis in immature rat and may be partially reversed by IL1RA", Epilepsia, 51, pp.34~38 (2010)
- Auvin S, "Inflammation enhances epileptogenesis in the developing rat brain", Neurobiol Dis, 40, pp.303~310 (2010)
- Vezzani A, "The role of inflammation in epilepsy", Nat Rev Neurol, 7, pp.31~40 (2011)
- Feng B, "Transient increase of interleukin-1β after prolonged febrile seizures promotes adult epileptogenesis through long-standing upregulating endocannabinoid signaling", Sci Rep, 6, pp.21931~ (2016)
- Heida JG, "The role of interleukin-1β in febrile seizures", Brain Dev, 31, pp.388~393 (2009)
- Dubé C, "Interleukin1beta contributes to the generation of experimental febrile seizures", Ann Neurol, 57, pp.152~155 (2005)
- Haspolat S, "Interleukin-1beta, tumor necrosis factor-alpha, and nitrite levels in febrile seizures", J Child Neurol, 17, pp.749~751 (2002)
- Patterson KP, "Origins of temporal lobe epilepsy : febrile seizures and febrile status epilepticus", Neurotherapeutics, 11, pp.242~250 (2014)
- Gallentine WB, "Plasma cytokines associated with febrile status epilepticus in children : a potential biomarker for acute hippocampal injury", Epilepsia, 58, pp.1102~1111 (2017)
- Heida JG, "Causal links between brain cytokines and experimental febrile convulsions in the rat", Epilepsia, 46, pp.1906~1913 (2005)
- Virta M, "Increased plasma levels of pro-and anti-inflammatory cytokines in patients with febrile seizures", Epilepsia, 43, pp.920~923 (2002)
- Crespel A, "Inflammatory reactions in human medial temporal lobe epilepsy with hippocampal sclerosis", Brain Res, 952, pp.159~169 (2002)
- Camfield P, "What types of epilepsy are preceded by febrile seizures? A population-based study of children", Dev Med Child Neurol, 36, pp.887~892 (1994)
- Rocca WA, "Risk factors for complex partial seizures : a population-based casecontrol study", Ann Neurol, 21, pp.22~31 (1987)
- Luders HO, "The epilepsies; etiologies and prevention", pp.121~124 (1999), Academic press
- Mathern GW, "Influence of the type of initial precipitating injury and at what age it occurs on course and outcome in patients with temporal lobe seizures", J Neurosurg, 82, pp.220~227 (1995)
- Bergamini L, "Acquired etiological factors in 1, 785 epileptic subjects : clinical-anamnestic research", Epilepsia, 18, pp.437~444 (1977)
- Davis LE, "The epilepsies: etiologies and prevention", pp.121~124 (1999), Academic press
- Sander JW, "National General Practice Study of Epilepsy : newly diagnosed epileptic seizures in a general population", Lancet, 336, pp.1267~1271 (1990)
- Theodore WH, "Human herpes virus 6B : a possible role in epilepsy?", Epilepsia, 49, pp.1828~1837 (2008)
- Granata T, "Immune-mediated epilepsies", Epilepsia, 52, pp.5~11 (2011)
- Yokoi S, "Hippocampal diffusion abnormality after febrile status epilepticus is related to subsequent epilepsy", Epilepsia, 60, pp.1306~1316 (2019)
- Vezzani A, "Epilepsy: a comprehensive textbook", pp.267~276 (2008), Lippincott Williams & Wilkins
- Holthausen H, "Pediatric epilepsy surgery", pp.273~277 (2017), John Libbey Eurotext
- Engel J Jr, "Surgical treatment of the epilepsies. Appendix II. Presugical Evaluation Protocols", pp.749~750 (1993), Raven Press
- Haut SR, "Seizure clustering", Epilepsy Behav, 8, pp.50~55 (2006)
- Engel J, "Surgical treatment of the epilepsies", pp.609~621 (1993), Raven Press
- Vezzani A, "Brain inflammation in epilepsy : experimental and clinical evidence", Epilepsia, 46, pp.1724~1743 (2005)
- Park S, "Hippocampal sclerosis and encephalomalacia as prognostic factors of tuberculous meningitis-related and herpes simplex encephalitis-related epilepsy", Seizure, 20, pp.570~574 (2011)
- Walker L, "Inflammation and epilepsy : the foundations for a new therapeutic approach in epilepsy?", Epilepsy Curr, 12, pp.8~12 (2012)
- Lee JH, "Experiences of epilepsy surgery in intractable seizures with past history of CNS infection", Yonsei Med J, 38, pp.73~78 (1997)
- Marks DA, "Characteristics of intractable seizures following meningitis and encephalitis", Neurology, 42, pp.1513~1518 (1992)
- Lancman ME, "Epilepsy after central nervous system infection : clinical characteristics and outcome after epilepsy surgery", Epilepsy Res, 25, pp.285~290 (1996)
- Wieser HG, "Recent advances in epilepsy", pp.57~79 (1986), Churchill Livingstone
- Palmini A, "The localizing value of auras in partial seizures : a prospective and retrospective study", Neurology, 42, pp.801~808 (1992)
- Van Buren JM, "The abdominal aura. A study of abdominal sensations occurring in epilepsy and produced by depth stimulation", Electroencephalogr Clin Neurophysiol, 15, pp.1~19 (1963)
- Kotagal P, "Epilepsy surgery", pp.143~155 (1991), Raven Press
- Tsugiko Kurita, "Very Long-Term Outcome of Non-Surgically Treated Patients with Temporal Lobe Epilepsy with Hippocampal Sclerosis: A Retrospective Study", PLOS ONE, 11(7), pp.e0159464~ (2016), Public Library of Science (PLoS)[DOI]
- Maher J, "Febrile convulsions. Is seizure duration the most important predictor of temporal lobe epilepsy?", Brain, 118, pp.1521~1528 (1995)
- Park S, "Prognostic analysis of patients with epilepsy according to time of relapse after withdrawal of antiepileptic drugs following four seizure-free years", Epilepsia, 58, pp.60~67 (2017)