Glucose Hypometabolism in Hippocampal Subdivisions in Alzheimer’s Disease: A Pilot Study Using High-Resolution 18F-FDG PET and 7.0-T MRI
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Background and Purpose Atrophy of the hippocampus is an important clinical diagnosticmarker of Alzheimer’s disease (AD), and so assessments of hippocampal activity and its subdivisionsmight provide invaluable information. This study compared the glucose metabolismof hippocampal subdivisions in mild-AD patients and healthy controls. Methods High-resolution T2*-weighted gradient-echo magnetic resonance imaging (MRI)images and 18F-fluorodeoxyglucose (FDG) positron-emission tomography (PET) images wereacquired using 7.0-T MRI and high-resolution research tomograph FDG-PET, respectively, in9 early-stage AD patients and 10 healthy subjects. The hippocampal body was divided intothree equal parts (anterior, middle, and posterior), and in each part a region of interest (ROI)was drawn over the cornus ammonis (CA)1, CA2/3, CA4/dentate gyrus (DG), and subiculum. The standardized uptake values of the hippocampal subdivisions were calculated for each ROIas ratios relative to the pons standardized uptake value. Statistical analysis was conducted usingthe Mann-Whitney U test. Results Patients with early-stage AD patients showed significantly less metabolic activitythan healthy controls focally in the middle (p=0.050) and posterior (p=0.034) CA2/3 regionsof the right hippocampus, and significantly less activity throughout the left hippocampal bodyin the anterior CA2/3 (p=0.027) and CA4/DG (p=0.027) regions, the middle CA1 region(p=0.011), and the posterior CA1 (p=0.034), CA2/3 (p=0.007), and CA4/DG (p=0.014) regions. Conclusions It was possible to use high-resolution PET-MRI fusion images to identify hippocampussubdivisions and assess glucose metabolism in the subfields. Reductions in metabolic activitywere found to vary along the hippocampal axis in early-stage AD patients.
Abstract
Background and Purpose Atrophy of the hippocampus is an important clinical diagnosticmarker of Alzheimer’s disease (AD), and so assessments of hippocampal activity and its subdivisionsmight provide invaluable information. This study compared the glucose metabolismof hippocampal subdivisions in mild-AD patients and healthy controls. Methods High-resolution T2*-weighted gradient-echo magnetic resonance imaging (MRI)images and 18F-fluorodeoxyglucose (FDG) positron-emission tomography (PET) images wereacquired using 7.0-T MRI and high-resolution research tomograph FDG-PET, respectively, in9 early-stage AD patients and 10 healthy subjects. The hippocampal body was divided intothree equal parts (anterior, middle, and posterior), and in each part a region of interest (ROI)was drawn over the cornus ammonis (CA)1, CA2/3, CA4/dentate gyrus (DG), and subiculum. The standardized uptake values of the hippocampal subdivisions were calculated for each ROIas ratios relative to the pons standardized uptake value. Statistical analysis was conducted usingthe Mann-Whitney U test. Results Patients with early-stage AD patients showed significantly less metabolic activitythan healthy controls focally in the middle (p=0.050) and posterior (p=0.034) CA2/3 regionsof the right hippocampus, and significantly less activity throughout the left hippocampal bodyin the anterior CA2/3 (p=0.027) and CA4/DG (p=0.027) regions, the middle CA1 region(p=0.011), and the posterior CA1 (p=0.034), CA2/3 (p=0.007), and CA4/DG (p=0.014) regions. Conclusions It was possible to use high-resolution PET-MRI fusion images to identify hippocampussubdivisions and assess glucose metabolism in the subfields. Reductions in metabolic activitywere found to vary along the hippocampal axis in early-stage AD patients.
참고문헌 (26)
- Duvernoy HM, "The Human Hippocampus: Functional Anatomy, Vascularization and Serial Sections with MRI, 3rd ed" (2005), Springer-Verlag
- Kerchner GA, "Hippocampal CA1 apical neuropil atrophy in mild Alzheimer disease visualized with 7-T MRI", Neurology, 75, pp.1381~1387 (2010)[DOI]
- Shastri L, "A computational model of episodic memory formation in the hippocampal system", Neurocomputing, 38, pp.889~897 (2001)
- Langston RF, "The role of hippocampal subregions in memory for stimulus associations", Behav Brain Res, 215, pp.275~291 (2010)[DOI]
- Weiner MW, "The Alzheimer's Disease Neuroimaging Initiative: a review of papers published since its inception", Alzheimers Dement, 8(1 Suppl), pp.S1~S68 (2012)[DOI]
- Theysohn JM, "The human hippocampus at 7 T--in vivo MRI", Hippocampus, 19, pp.1~7 (2009)[DOI]
- Cho ZH, "Quantitative analysis of the hippocampus using images obtained from 7.0 T MRI", Neuroimage, 49, pp.2134~2140 (2010)[DOI]
- Bobinski M, "Atrophy of hippocampal formation subdivisions correlates with stage and duration of Alzheimer disease", Dementia, 6, pp.205~210 (1995)
- Kerchner GA, "Hippocampal CA1 apical neuropil atrophy and memory performance in Alzheimer's disease", Neuroimage, 63, pp.194~202 (2012)[DOI]
- Herholz K, "NeuroPET: Positron Emission Tomography in Neuroscience and Clinical Neurology; with 66 Figures and 11 Tables" (2004), Springer-Verlag
- Lewczuk P, "Biomarkers of Alzheimer's disease and mild cognitive impairment: a current perspective", Adv Med Sci, 60, pp.76~82 (2015)[DOI]
- Wienhard K, "The ECAT HRRT: performance and first clinical application of the new high resolution research tomograph", IEEE Trans Nucl Sci, 49, pp.104~110 (2002)[DOI]
- Cho ZH, "Substructural hippocampal glucose metabolism observed on PET", MRI, 2010, pp.51, 1545~1548
- McKhann G, "Clinical diagnosis of Alzheimer's disease: report of the NINCDSADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease", Neurology, 34, pp.939~944 (1984)[DOI]
- 안현정, "Seoul Neuropsychological Screening Battery-Dementia Version (SNSB-D): A Useful Tool for Assessing and Monitoring Cognitive Impairments in Dementia Patients", Journal of Korean Medical Science, 25(7), pp.1071~1076 (2010), 대한의학회
- Cho ZH, "A fusion PET-MRI system with a high-resolution research tomograph-PET and ultra-high field 7.0 T-MRI for the molecular-genetic imaging of the brain", Proteomics, 8, pp.1302~1323 (2008)[DOI]
- Mueller SG, "Measurement of hippocampal subfields and age-related changes with high resolution MRI at 4T", Neurobiol Aging, 28, pp.719~726 (2007)[DOI]
- Schonheit B, "Spatial and temporal relationships between plaques and tangles in Alzheimer-pathology", Neurobiol Aging, 25, pp.697~711 (2004)[DOI]
- Apostolova LG, "3D comparison of hippocampal atrophy in amnestic mild cognitive impairment and Alzheimer's disease", Brain, 129, pp.2867~2873 (2006)[DOI]
- de Flores R, "Structural imaging of hippocampal subfields in healthy aging and Alzheimer's disease", Neuroscience, 309, pp.29~50 (2015)[DOI]
- Hanseeuw BJ, "Mild cognitive impairment: differential atrophy in the hippocampal subfields", AJNR Am J Neuroradiol, 32, pp.1658~1661 (2011)[DOI]
- Lim HK, "Automated hippocampal subfield segmentation in amnestic mild cognitive impairments", Dement Geriatr Cogn Disord, 33, pp.327~333 (2012)[DOI]
- Lim HK, "Automated segmentation of hippocampal subfields in drug-naive patients with Alzheimer disease", AJNR Am J Neuroradiol, 34, pp.747~751 (2013)[DOI]
- Yushkevich PA, "Automated volumetry and regional thickness analysis of hippocampal subfields and medial temporal cortical structures in mild cognitive impairment", Hum Brain Mapp, 36, pp.258~287 (2015)[DOI]
- Derflinger S, "Greymatter atrophy in Alzheimer's disease is asymmetric but not lateralized", J Alzheimers Dis, 25, pp.347~357 (2011)[DOI]
- Murray ME, "Neuropathologically defined subtypes of Alzheimer's disease with distinct clinical characteristics: a retrospective study", Lancet Neurol, 10, pp.785~796 (2011)[DOI]