본문 바로가기
KERD
논문KCI 등재

A Rare Case of Polycythemia Vera Following Acute Undifferentiated Leukemia Remission

윤수영|최철원|이종한|임채승|조치현|육희정
대한진단검사의학회 (Korean Society For Laboratory Medicine)|2014.11|Annals of Laboratory Medicine|제34권 제6호|pp. 469-470

2

조회

0

다운로드

1

인용

0

참고문헌

주제분류병리학

초록

Polycythemia vera (PV) is a myeloproliferative neoplasm (MPN) characterized by the abnormal proliferation of red blood cells, and it is associated with leukocytosis and thrombocytosis [1]. A Janus kinase 2 ( JAK2 ) V617F mutation is found in 95% of PV patients and influences its pathogenesis and diagnosis [1-4]. Generally, AML development is a late event in PV patients [1, 5], and leukemic transformation occurs in 5-15% of patients [4]. We report a case of PV after complete remission (CR) of acute undifferentiated leukemia.

Abstract

Polycythemia vera (PV) is a myeloproliferative neoplasm (MPN) characterized by the abnormal proliferation of red blood cells, and it is associated with leukocytosis and thrombocytosis [1]. A Janus kinase 2 ( JAK2 ) V617F mutation is found in 95% of PV patients and influences its pathogenesis and diagnosis [1-4]. Generally, AML development is a late event in PV patients [1, 5], and leukemic transformation occurs in 5-15% of patients [4]. We report a case of PV after complete remission (CR) of acute undifferentiated leukemia.

참고문헌 (10)

  1. Passamonti F, "A prospective study of 338 patients with polycythemia vera: the impact of JAK2 (V617F) allele burden and leukocytosis on fibrotic or leukemic disease transformation and vascular complications", Leukemia, 24, pp.1574~1579 (2010)
  2. Antonioli E, "Polycythemia vera following autologous transplantation for AML: insights on the kinetics of JAK2V617F clonal dominance", Blood, 110, pp.4620~4621 (2007)
  3. Tefferi A, "Polycythemia vera and essential thrombocythemia: 2013 update on diagnosis, risk-stratification, and management", Am J Hematol, 88, pp.507~516 (2013)
  4. Lee HJ, "The role of JAK pathway dysregulation in the pathogenesis and treatment of acute myeloid leukemia", Clin Cancer Res, 19, pp.327~335 (2013)
  5. Gangat N, "Leucocytosis in polycythaemia vera predicts both inferior survival and leukaemic transformation", Br J Haematol, 138, pp.354~358 (2007)
  6. Dong Wook Jekarl, "JAK2 V617F mutation in myelodysplastic syndrome, myelodysplastic syndrome", myeloproliferative neoplasm, unclassifiable, refractory anemia with ring sideroblasts with thrombocytosis, and acute myeloid leukemia, 2010, pp.45(1), 46~50[DOI]
  7. Swaminathan S, "Novel immunophenotypic and morphologic presentation in acute myeloid leukemia (AML) with JAK2 V617F mutation", Eur J Haematol, 84, pp.180~182 (2010)
  8. Belotti A, "Development of polycythemia vera after chemotherapy-induced remission of acute myeloid leukemia: a case report", Acta Haematol, 126, pp.52~53 (2011)
  9. Portell CA, "De novo polycythaemia vera arising 5 years following acute myeloid leukemia remission: suggestion of a chemotherapy resistant JAK2 clone", Br J Haematol, 157, pp.266~267 (2012)
  10. Chabannon C, "A case of polycythemia vera occurring in a patient with acute non-lymphoblastic leukemia (ANLL) in long-term first complete remission", Leukemia, 8, pp.1243~1244 (1994)

관련 논문AI추천

JAK2 V617F-Positive Acute Myeloid Leukemia: Clinicopathological Features of Two Cases방수미, 이영은, 이정옥, 이지윤, 황상미대한진단검사의학회 · Laboratory Medicine Online2022 · 제12권 제1호Diagnostic Usefulness of the Janus Kinase 2 Mutation in non­BCR/ABL Myeloproliferative Disorders박필환, 방수미, 서일혜, 안정열, Dong Bok Shin, Eun Kyung Cho, Eun Mi Nam, Jae Hoon Lee, Jiyoon Park, Se Hoon Park, Soo Jin Yoo대한내과학회 · The Korean Journal of Internal Medicine2006 · 제21권 제4호Correlations between Janus Kinase 2 V617F Allele Burdens and Clinicohematologic Parameters in Myeloproliferative Neoplasms김유경, 정순일, 정인성, 정혜라, 하정숙대한진단검사의학회 · Annals of Laboratory Medicine2012 · 제32권 제6호Two Cases of Myeloproliferative Neoplasm with a Concurrent JAK2V617F Mutation and BCR/ABL Translocation without Chronic Myelogenous Leukemia Phenotype Acquisition during Hydroxyurea Treatment김대영, 박상혁, 박찬정, 이규형, 이제환, 장성수, 지현숙, 최영욱대한진단검사의학회 · Annals of Laboratory Medicine2013 · 제33권 제3호JAK2V617F 돌연변이를 보인 비정형만성골수성백혈병 1예김병수, 김영기, 김주연, 남명현, 윤수영, 이갑노, 이세련, 이창규, 임채승, 조윤정대한진단검사의학회 · Laboratory Medicine Online2011 · 제1권 제4호Straightforward Identification of Masked Polycythemia Vera Based on Proposed Revision of World Health Organization Diagnostic Criteria for BCR-ABL1-Negative Myeloproliferative Neoplasms박찬정, 서을주, 장성수, 조영욱, 주대현대한진단검사의학회 · Annals of Laboratory Medicine2015 · 제35권 제6호

이 간행물의 다른 논문 (14건)

Cancer Cytogenetics: Methodology RevisitedThomas S. K. Wanpp. 413-425CD34 and p53 Immunohistochemical Stains Differentiate Hypocellular Myelodysplastic Syndrome (hMDS) from Aplastic Anemia and a CD34 Immunohistochemical Stain Provides Useful Survival Information for hMDS임호준, 이규형, 장성수, 차충환, 서을주, 이제환, 이정희, 서종진, 지현숙, 조영욱, 박찬정pp. 426-432Correlation of Ciprofloxacin Resistance with the AdeABC Efflux System in Acinetobacter baumannii Clinical IsolatesAbdolaziz Rastegar Lari, Abdollah Ardebili, Malihe Talebipp. 433-438Comparison of Supplemented Brucella Agar and Modified Clostridium difficile Agar for Antimicrobial Susceptibility Testing of Clostridium difficile강정옥, 김지은, 배현주, 김계형pp. 439-445Evaluation of PCR-Reverse Blot Hybridization Assay, REBA Sepsis-ID Test, for Simultaneous Identification of Bacterial Pathogens and mecA and van Genes from Blood Culture Bottles왕혜영, 이혜영, 김정호, 김현정, 김영근, 박민, 김성현, 이규상, 김종배, 어영, 김효열, 박순덕pp. 446-455
원문 보기