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Species-Specific Difference in Antimicrobial Susceptibility Among Viridans Group Streptococci

이남용|허희재|천세종
대한진단검사의학회 (Korean Society For Laboratory Medicine)|2015.03|Annals of Laboratory Medicine|제35권 제2호|pp. 205-211

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키워드

ResistanceMicrobialPenicillinViridans streptococci
주제분류병리학

초록

Background: Viridans group streptococci (VGS) are both commensal microbes and potential pathogens. Increasing resistance to penicillin in VGS is an ongoing issue in the clinical environment. We investigated the difference in susceptibility and resistance to penicillin among various VGS species. Methods: In total 1,448 VGS isolated from various clinical specimens were analyzed over a two-yr period. Identification and antimicrobial susceptibility test was performed by the automated VITEK 2 system (bioMerieux, France) or the MicroScan MICroSTREP system (Siemens, Germany). Results: Among the 1,448 isolates, 412 were isolated from blood (28.4%). Streptococcus mitis group was the most frequently isolated (589 isolates, 40.7%), followed by the S. anginosus group (290 isolates, 20.0%), S. sanguinis group (179 isolates, 12.4%) and S. salivarius group (57 isolates, 3.9%). In total, 314 isolates could not be identified up to the species level. The overall non-susceptibility to penicillin was observed to be 40.0% (resistant, 11.2% and intermediately resistant, 28.8%) with uneven distribution among groups; 40.2% in S. sanguinis group (resistant, 5.0% and intermediately resistant, 35.2%), 60.3% in S. mitis group (resistant, 20.9% and intermediately resistant, 39.4%), 78.9% in S. salivarius group (resistant, 8.8% and intermediately resistant, 70.1%), and 6.2% in S. anginosus group (resistant, 1.7% and intermediately resistant, 4.5%). Conclusions: Antimicrobial resistance patterns towards penicillin show differences among various VGS; this should be considered while devising an effective antimicrobial treatment against VGS.

Abstract

Background: Viridans group streptococci (VGS) are both commensal microbes and potential pathogens. Increasing resistance to penicillin in VGS is an ongoing issue in the clinical environment. We investigated the difference in susceptibility and resistance to penicillin among various VGS species. Methods: In total 1,448 VGS isolated from various clinical specimens were analyzed over a two-yr period. Identification and antimicrobial susceptibility test was performed by the automated VITEK 2 system (bioMerieux, France) or the MicroScan MICroSTREP system (Siemens, Germany). Results: Among the 1,448 isolates, 412 were isolated from blood (28.4%). Streptococcus mitis group was the most frequently isolated (589 isolates, 40.7%), followed by the S. anginosus group (290 isolates, 20.0%), S. sanguinis group (179 isolates, 12.4%) and S. salivarius group (57 isolates, 3.9%). In total, 314 isolates could not be identified up to the species level. The overall non-susceptibility to penicillin was observed to be 40.0% (resistant, 11.2% and intermediately resistant, 28.8%) with uneven distribution among groups; 40.2% in S. sanguinis group (resistant, 5.0% and intermediately resistant, 35.2%), 60.3% in S. mitis group (resistant, 20.9% and intermediately resistant, 39.4%), 78.9% in S. salivarius group (resistant, 8.8% and intermediately resistant, 70.1%), and 6.2% in S. anginosus group (resistant, 1.7% and intermediately resistant, 4.5%). Conclusions: Antimicrobial resistance patterns towards penicillin show differences among various VGS; this should be considered while devising an effective antimicrobial treatment against VGS.

참고문헌 (23)

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관련 논문AI추천

Comparison of Three Antibiotic Susceptibility Tests for Viridans Group Streptococci김연희, 이시영대한구강생물학회 · International Journal of Oral Biology2011 · 제36권 제4호Evaluation of the MicroScan MICroSTREP Plus Antimicrobial Panel for Testing ß-Hemolytic Streptococci and Viridans Group Streptococci어영, 김성주, 박순덕, 윤갑준, 이관수, 장인호대한진단검사의학회 · Annals of Laboratory Medicine2011 · 제31권 제3호Viridans Streptococci 균혈증의 임상적 의의이남용, 조은해대한진단검사의학회 · Annals of Laboratory Medicine2003 · 제23권 제4호Identification of viridans streptococci With Matrix-Assisted Laser Desorption & Ionization Time-of-flight Mass Spectrometry by an In-house Method and a Commercially Available SystemArne C. Rodloff, Catalina-Suzana Stingu, Juliane Thiel, Klaus Eschrich, Reiner Schaumann, Toralf Borgmann대한진단검사의학회 · Annals of Laboratory Medicine2017 · 제37권 제5호임상검체에서 분리된 사슬알균종의 분리빈도와 항균제 감수성박연보, 신현성대한임상검사과학회 · 대한임상검사과학회지2008 · 제40권 제1호Comparison between the Rapid ID 32 Strep test system and 16S rRNA gene sequencing for the identification of α-hemolytic streptococciSi Young Lee치의학연구원 · Oral Biology Research2021 · 제45권 제3호

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