A Fatal Case of Naegleria fowleri Meningoencephalitis in Taiwan
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After bathing at a hot spring resort, a 75-year-old man presented to the emergency department because of seizure-like attack with loss of conscious. This is the first case of primary amebic meningoencephalitis (PAM) caused by Naegleria fowleri in Taiwan. PAM was diagnosed based on detection of actively motile trophozoites in cerebrospinal fluid using a wet-mount smear and the Liu’s stain. The amoebae were further confirmed by PCR and gene sequencing. In spite of administering amphotericin B treatment, the patient died 25 days later.
Abstract
After bathing at a hot spring resort, a 75-year-old man presented to the emergency department because of seizure-like attack with loss of conscious. This is the first case of primary amebic meningoencephalitis (PAM) caused by Naegleria fowleri in Taiwan. PAM was diagnosed based on detection of actively motile trophozoites in cerebrospinal fluid using a wet-mount smear and the Liu’s stain. The amoebae were further confirmed by PCR and gene sequencing. In spite of administering amphotericin B treatment, the patient died 25 days later.
참고문헌 (13)
- Schuster FL, "Free-living amoebae as opportunistic and non-opportunistic pathogens of humans and animals", Int J Parasitol, 34, pp.1001~1027 (2004)
- Visvesvara GS, "Pathogenic and opportunistic free-living amoebae: Acanthamoeba spp., Balamuthia mandrillaris, Naegleria fowleri, and Sappinia diploidea", FEMS Immunol Med Microbiol, 50, pp.1~26 (2007)
- da Rocha-Azevedo B, "Diagnosis of infections caused by pathogenic free-living amoebae", Interdiscip Perspect Infect Dis, 251406, pp.1~14 (2009)
- Heggie TW, "Swimming with death: Naegleria fowleri infections in recreational waters", Travel Med Infect Dis, 8, pp.201~206 (2010)
- Martinez AJ, "Free-living, amphizoic and opportunistic amebas", Brain Pathol, 7, pp.583~598 (1997)
- Schild M, "PCR-based diagnosis of Naegleria sp. infection in formalin-fixed and paraffinembedded brain sections", J Clin Microbiol, 45, pp.564~567 (2007)
- Qvarnstrom Y, "Multiplex real- time PCR assay for simultaneous detection of Acanthamoeba spp., Balamuthia mandrillaris, and Naegleria fowleri", J Clin Microbiol, 44, pp.3589~3595 (2006)
- de Jonckheere J, "The distribution of Naegleria fowleri in man-made thermal waters", Am J Trop Med Hyg, 26, pp.10~15 (1977)
- Tyndall RL, "Effect of thermal additions on the density and distribution of thermophilic amoebae and pathogenic Naegleria fowleri in a newly created cooling lake", Appl Environ Microbiol, 55, pp.722~732 (1989)
- Kidney DD, "CNS infections with free-living amebas: neuroimaging findings", AJR Am J Roentgenol, 171, pp.809~812 (1998)
- Schumacher DJ, "Neuroimaging findings in rare amebic infections of the central nervous system", AJNR Am J Neuroradiol, 16, pp.930~935 (1995)
- Carter RF, "Sensitivity to amphotericin B of a Naegleria sp. isolated from a case of primary amoebic meningoencephalitis", J Clin Pathol, 22, pp.470~474 (1969)
- Vargas-Zepeda J, "Successful treatment of Naegleria fowleri meningoencephalitis by using intravenous amphotericin B, fluconazole and rifampicin", Arch Med Res, 36, pp.83~86 (2005)
