Seropositivity of Toxoplasmosis in Pregnant Women by ELISA at Minia University Hospital, Egypt
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Toxoplasmosis is considered as an important risk factor for bad obstetric history (BOH) and one of the major causes of congenitally acquired infections. The present study aimed to estimate the seropositivity of T. gondii infection and associated risk factors among the attendees of high risk pregnancy and low risk antenatal care clinic of Minia Maternity and Pediatric University Hospital, Minia, Egypt. The study was carried out from April 2013 to April 2014 through 2 phases, the first phase was case-control study, and the second phase was follow-up with intervention. A total of 120 high risk pregnant and 120 normal pregnant females were submitted to clinical examinations, serological screening for anti-Toxoplasma IgM and IgG antibodies by ELISA, and an interview questionnaire. Seropositive cases were subjected to spiramycin course treatment. The results showed that the seroprevalence of toxoplasmosis in high-risk pregnancy group was 50.8%, which was significantly different from that of normal pregnancy group (P<0.05). Analysis of seropositive women in relation to BOH showed that abortion was the commonest form of the pregnancy wastage (56.5%). The high prevalence of T. gondii seropositive cases was observed in the age group of 21-30 years. Post-delivery adverse outcome was observed in 80.3% of high-risk pregnancy group compared to 20% of normal pregnancy group. There was a statistically significant relationship between seropositivity and living in rural area, low socioeconomic level, and undercooked meat consumption (P<0.05). Serological screening for anti-Toxoplasma antibodies should be routine tests especially among high-risk pregnant women.
Abstract
Toxoplasmosis is considered as an important risk factor for bad obstetric history (BOH) and one of the major causes of congenitally acquired infections. The present study aimed to estimate the seropositivity of T. gondii infection and associated risk factors among the attendees of high risk pregnancy and low risk antenatal care clinic of Minia Maternity and Pediatric University Hospital, Minia, Egypt. The study was carried out from April 2013 to April 2014 through 2 phases, the first phase was case-control study, and the second phase was follow-up with intervention. A total of 120 high risk pregnant and 120 normal pregnant females were submitted to clinical examinations, serological screening for anti-Toxoplasma IgM and IgG antibodies by ELISA, and an interview questionnaire. Seropositive cases were subjected to spiramycin course treatment. The results showed that the seroprevalence of toxoplasmosis in high-risk pregnancy group was 50.8%, which was significantly different from that of normal pregnancy group (P<0.05). Analysis of seropositive women in relation to BOH showed that abortion was the commonest form of the pregnancy wastage (56.5%). The high prevalence of T. gondii seropositive cases was observed in the age group of 21-30 years. Post-delivery adverse outcome was observed in 80.3% of high-risk pregnancy group compared to 20% of normal pregnancy group. There was a statistically significant relationship between seropositivity and living in rural area, low socioeconomic level, and undercooked meat consumption (P<0.05). Serological screening for anti-Toxoplasma antibodies should be routine tests especially among high-risk pregnant women.
참고문헌 (22)
- Dubey JP, "Toxoplasmosis of Animals and Humans" (2010), CRC Press
- Torgerson PR, "Global burden of congenital toxoplasmosis: systematic review", Bull World Health Organ, 91, pp.501~508 (2013)
- Fricker-Hidalgo H, "Toxoplasma seroconversion with negative or transient immunoglobulin M in pregnant women: myth or reality? A French multicenter retrospective study", J Clin Microbiol, 51, pp.2103~2111 (2013)
- Sarkar MD, "Seropositivity of toxoplasmosis in antenatal women with bad obstetric history in a tertiary-care hospital of Andhra Pradesh, India", J Health Popul Nutr, 30, pp.87~92 (2012)
- Kumari N, "Is screening of TORCH worthwhile in women with bad obstetric history: an observation from eastern Nepal", J Health Popul Nutr, 29, pp.77~80 (2011)
- Yasodhara P, "Socioeconomic status and prevalence of toxoplasmosis during pregnancy", Indian J Med Microbiol, 22, pp.241~243 (2004)
- McLeod R, "Nelson Textbook of Pediatrics", pp.1054~1062 (2000), WB Saunders
- El Deeb HK, "Prevalence of Toxoplasma gondii infection in antenatal population in Menoufia governorate, Egypt", Acta Trop, 124, pp.185~191 (2012)
- Schiesselman JJ, "Case-Control studies. Design, Conduct, Analysis", pp.1~354 (1982), Oxford University Press
- Tammam AE, "Seroepidemiology of Toxoplasma gondii infection in women with first trimester spontaneous miscarriage in Qena governorate, Egypt", J Clin Diagn Res, 7, pp.2870~2873 (2013)
- Chintapally S, "Seroprevalence of toxoplasmosis in antenatal women with bad obstetric history", Trop Parasitol, 3, pp.62~66 (2013)
- Senthamarai S, "Seroprevalence of toxoplasmosis in pregnant women with bad obstetric history in a tertiary care hospital, Kanchipuram-a pilot study", Disease, 3, pp.29~32 (2013)
- Hussein AH, "Seroprevalence of Toxoplasma infection in Qualyobia governorate, Egypt", J Egypt Soc Parasitol, 31, pp.355~363 (2001)
- Zemene E, "Seroprevalence of Toxoplasma gondii and associated risk factors among pregnant women in Jimma town, south western Ethiopia", BMC Infect Dis, 12, pp.337~ (2012)
- Spalding SM, "Serological screening and toxoplasmosis exposure factors among pregnant women in south of Brazil", Rev Soc Bras Med Trop, 38, pp.173~177 (2005)
- Malarvizhi A, "Seroprevalence of Toxoplasma gondii in pregnant women", J Public Health Epidemiol, 4, pp.170~177 (2012)
- Siddiqui N, "Socioeconomic status and prevalence of toxoplasmosis in pregnant women with bad obstetric history", J Immunol Vaccine Technol, 1, pp.101~103 (2014)
- Li XL, "A meta-analysis on risks of adverse pregnancy outcomes in Toxoplasma gondii infection", PLoS One, 9 (2014)
- Ajayi GO, "Prenatal diagnosis of cytomegalovirus (CMV), rubella, toxoplasmosis, varicella, parvovirus, herpes simplex and syphilis. The lagos programme experience", Clin Exp Obstet Gynecol, 37, pp.37~38 (2010)
- Cortina-Borja M, "European Multicentre Study on Congenital Toxoplasmosis (EMSCOT) Prenatal treatment for serious neurological sequelae of congenital toxoplasmosis: an observational prospective cohort study", PLoS Med, 7 (2010)
- Liu Q, "Toxoplasma gondii infection in pregnant women in China", Trans R Soc Trop Med Hyg, 103, pp.162~166 (2009)
- Mohammed TK, "Seroprevalence of Toxoplasma gondii among pregnant women in Baghdad city", Iraq Acad Sci J, 24, pp.21~28 (2011)