Incidence and Prevalence of Myasthenia Gravis in Korea: A Population-Based Study Using the National Health Insurance Claims Database
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Background and PurposezzTere have been a few national population-based epidemiological studies of myasthenia gravis (MG) with wide variation of incidence and prevalence rates worldwide. Herein we report the frst nationwide population-based epidemiological study of MG in Korea. MethodszzWe attempted to estimate the incidence and prevalence rates of MG using the Korean National Health Insurance claims database for 2010 to 2013. Cases with MG were defned as those having claim records with a principal diagnosis of MG and the prescription of acetylcholinesterase inhibitors or immunosuppressive agents including corticosteroids and azathioprine within 2 years afer the diagnosis. Te year 2010 was set as a washout period, such that patients were defned as incident cases if their frst records of MG were observed in 2011. ResultszzIn 2011 there were 1,236 incident cases, and the standardized incidence rate was 2.44 per 100,000 person-years. Te standardized prevalence rates were 9.67 and 10.66 per 100,000 persons in 2010 and 2011, respectively. Te incidence and prevalence rates peaked in the elderly population aged 60 to 69 years for both sexes. ConclusionszzTis is one of the largest national population-based epidemiological studies of MG, and it has confrmed the high incidence and prevalence rates of MG in the elderly population of South Korea.
Abstract
Background and PurposezzTere have been a few national population-based epidemiological studies of myasthenia gravis (MG) with wide variation of incidence and prevalence rates worldwide. Herein we report the frst nationwide population-based epidemiological study of MG in Korea. MethodszzWe attempted to estimate the incidence and prevalence rates of MG using the Korean National Health Insurance claims database for 2010 to 2013. Cases with MG were defned as those having claim records with a principal diagnosis of MG and the prescription of acetylcholinesterase inhibitors or immunosuppressive agents including corticosteroids and azathioprine within 2 years afer the diagnosis. Te year 2010 was set as a washout period, such that patients were defned as incident cases if their frst records of MG were observed in 2011. ResultszzIn 2011 there were 1,236 incident cases, and the standardized incidence rate was 2.44 per 100,000 person-years. Te standardized prevalence rates were 9.67 and 10.66 per 100,000 persons in 2010 and 2011, respectively. Te incidence and prevalence rates peaked in the elderly population aged 60 to 69 years for both sexes. ConclusionszzTis is one of the largest national population-based epidemiological studies of MG, and it has confrmed the high incidence and prevalence rates of MG in the elderly population of South Korea.
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