Increasing Trends in the Incidence and Prevalence of Epilepsy in Korea
1
조회
0
다운로드
5
인용
0
참고문헌
키워드
초록
Background and Purpose There have been few reports on recent trends in the occurrence of epilepsy. The aim of this study was to estimate the incidence and prevalence of epilepsy and analyze their annual trends in Korea over the period 2009–2017. Methods This nationwide population-based study was carried out using the National Health Insurance Service of Korea database. A prevalent case was defined as one of a patient receiving a prescription of anticonvulsants under the diagnostic codes for epilepsy or seizure. An incident case was ascertained by confirming the absence of any epilepsy-related diagnostic codes and anticonvulsant prescription for 2 years or more before the operational definition for a prevalent case was met. Alternative operational definitions for epilepsy were tested. The temporal trends of the incidence and prevalence of epilepsy were analyzed using a Poisson regression model, and are expressed as average annual percentage changes (AAPCs). Results The incidence of epilepsy increased from 28.7/100,000 persons in 2009 to 35.4/100,000 persons in 2017. The prevalence increased gradually from 3.4/1,000 persons in 2009 to 4.8/1,000 persons in 2017. These increasing trends were more evident among elderly subjects aged ≥75 years and in those who had codes for epilepsy or seizure as an additional diagnosis. Age standardization revealed a less prominent but still increasing trend in both incidence (AAPC=0.48%) and prevalence (AAPC=3.11%). Conclusions There have been increasing trends in both the prevalence and incidence of epilepsy in Korea between 2009 and 2017. This finding appears to be related to societal aging and the high incidence of symptomatic epilepsy in the elderly population.
Abstract
Background and Purpose There have been few reports on recent trends in the occurrence of epilepsy. The aim of this study was to estimate the incidence and prevalence of epilepsy and analyze their annual trends in Korea over the period 2009–2017. Methods This nationwide population-based study was carried out using the National Health Insurance Service of Korea database. A prevalent case was defined as one of a patient receiving a prescription of anticonvulsants under the diagnostic codes for epilepsy or seizure. An incident case was ascertained by confirming the absence of any epilepsy-related diagnostic codes and anticonvulsant prescription for 2 years or more before the operational definition for a prevalent case was met. Alternative operational definitions for epilepsy were tested. The temporal trends of the incidence and prevalence of epilepsy were analyzed using a Poisson regression model, and are expressed as average annual percentage changes (AAPCs). Results The incidence of epilepsy increased from 28.7/100,000 persons in 2009 to 35.4/100,000 persons in 2017. The prevalence increased gradually from 3.4/1,000 persons in 2009 to 4.8/1,000 persons in 2017. These increasing trends were more evident among elderly subjects aged ≥75 years and in those who had codes for epilepsy or seizure as an additional diagnosis. Age standardization revealed a less prominent but still increasing trend in both incidence (AAPC=0.48%) and prevalence (AAPC=3.11%). Conclusions There have been increasing trends in both the prevalence and incidence of epilepsy in Korea between 2009 and 2017. This finding appears to be related to societal aging and the high incidence of symptomatic epilepsy in the elderly population.
참고문헌 (27)
- Hirtz D, "How common are the"common"neurologic disorders?", Neurology, 68, pp.326~337 (2007)
- Ngugi AK, "Estimation of the burden of active and life-time epilepsy : a meta-analytic approach", Epilepsia, 51, pp.883~890 (2010)
- Fiest KM, "Prevalence and incidence of epilepsy : a systematic review and meta-analysis of international studies", Neurology, 88, pp.296~303 (2017)
- Dent W, "Prevalence of active epilepsy in a rural area in South Tanzania : a doorto-door survey", Epilepsia, 46, pp.1963~1969 (2005)
- Karaagaç N, "Prevalence of epilepsy in Silivri, a rural area of Turkey", Epilepsia, 40, pp.637~642 (1999)
- Medina MT, "Prevalence, incidence, and etiology of epilepsies in rural Honduras : the Salamá Study", Epilepsia, 46, pp.124~131 (2005)
- Granieri E, "A descriptive study of epilepsy in the district of Copparo, Italy, 1964-1978", Epilepsia, 24, pp.502~514 (1983)
- Kelvin EA, "Prevalence of self-reported epilepsy in a multiracial and multiethnic community in New York City", Epilepsy Res, 77, pp.141~150 (2007)
- Reggio A, "Prevalence of epilepsy. A door-to-door survey in the Sicilian community of Riposto", Ital J Neurol Sci, 17, pp.147~151 (1996)
- de Boer HM, "The global burden and stigma of epilepsy", Epilepsy Behav, 12, pp.540~546 (2008)
- Banerjee PN, "The descriptive epidemiology of epilepsy-a review", Epilepsy Res, 85, pp.31~45 (2009)
- Lavados J, "A descriptive study of epilepsy in the district of El Salvador, Chile, 1984-1988", Acta Neurol Scand, 85, pp.249~256 (1992)
- Olafsson E, "Incidence of epilepsy in rural Iceland : a population-based study", Epilepsia, 37, pp.951~955 (1996)
- Hauser WA, "Incidence of epilepsy and unprovoked seizures in Rochester, Minnesota : 1935-1984", Epilepsia, 34, pp.453~468 (1993)
- "Entire population table of census 2019"[URL]
- Choi H, "Predictors of incident epilepsy in older adults : the Cardiovascular Health Study", Neurology, 88, pp.870~877 (2017)
- Mendez M, "Seizures in elderly patients with dementia : epidemiology and management", Drugs Aging, 20, pp.791~803 (2003)
- Epilepsy: a public health imperative, "World Health Organization", WHO, ~ (2019)
- 이서영, "Estimating the Prevalence of Treated Epilepsy Using Administrative Health Data and Its Validity: ESSENCE Study", Journal of Clinical Neurology, 12(4), pp.434~440 (2016), 대한신경과학회[DOI]
- 이서영, "Prevalence of Treated Epilepsy in Korea Based on National Health Insurance Data", Journal of Korean Medical Science, 27(3), pp.285~290 (2012), 대한의학회
- Benn EK, "Estimating the incidence of first unprovoked seizure and newly diagnosed epilepsy in the low-income urban community of Northern Manhattan, New York City", Epilepsia, 49, pp.1431~1439 (2008)
- Olafsson E, "Incidence of unprovoked seizures and epilepsy in Iceland and assessment of the epilepsy syndrome classification : a prospective study", Lancet Neurol, 4, pp.627~634 (2005)
- Okamoto K, "Incidence of childhood epilepsy : a population-based study in rural Japan", Brain Dev, 40, pp.904~908 (2018)
- Cowan LD, "The epidemiology of the epilepsies in children", Ment Retard Dev Disabil Res Rev, 8, pp.171~181 (2002)
- Heaney DC, "Socioeconomic variation in incidence of epilepsy : prospective community based study in south east England", BMJ, 325, pp.1013~1016 (2002)
- Kotsopoulos IA, "Systematic review and meta-analysis of incidence studies of epilepsy and unprovoked seizures", Epilepsia, 43, pp.1402~1409 (2002)
- Mbizvo GK, "The accuracy of using administrative healthcare data to identify epilepsy cases : a systematic review of validation studies", Epilepsia, 61, pp.1319~1335 (2020)