Schistosoma mansoni Infection and Its Related Morbidity among Adults Living in Selected Villages of Mara Region, North-Western Tanzania: A Cross-Sectional Exploratory Study
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Schistosoma mansoni is highly endemic in Tanzania and affects all age groups at different degrees. However, its control approach does not include adult individuals who are equally at risk and infected. To justify the inclusion of adult individuals in MDA programs in Tanzania, the present study focused on determining the prevalence of S. mansoni infection and its related morbidities among adult individuals. This was a cross sectional study conducted among 412 adult individuals aged 18-89 years living in selected villages of Rorya and Butiama districts located along the shoreline of the Lake Victoria. A pretested questionnaire was used to collect socio-demographic and socio-economic information of participants. Ultrasonographic examinations were conducted for all study participants using the Niamey protocol. A single stool sample was obtained from all study participants and examined for S. mansoni using the Kato-Katz technique. The study revealed a high prevalence of S. mansoni (56.3%), and the majority of infected individuals had a light intensity of infection. Ultrasonographic findings revealed that 22.4% of adult individuals had periportal fibrosis (PPF) (grade C-F), with 18.4% having grade C and D and 4% having grade E and F. Males had the highest prevalence of PPF (31.7% vs 10.8%, P<0.001). Organomegaly was common with 28.5% and 29.6% having splenomegaly and hepatomegaly, respectively. S. mansoni infection and its related morbidities included PPF, hepatomegaly, and splenomegaly were common among adult individuals. To reduce the level of transmission of S. mansoni infection, planned mass drug administration campaigns should include adult individuals living in these villages.
Abstract
Schistosoma mansoni is highly endemic in Tanzania and affects all age groups at different degrees. However, its control approach does not include adult individuals who are equally at risk and infected. To justify the inclusion of adult individuals in MDA programs in Tanzania, the present study focused on determining the prevalence of S. mansoni infection and its related morbidities among adult individuals. This was a cross sectional study conducted among 412 adult individuals aged 18-89 years living in selected villages of Rorya and Butiama districts located along the shoreline of the Lake Victoria. A pretested questionnaire was used to collect socio-demographic and socio-economic information of participants. Ultrasonographic examinations were conducted for all study participants using the Niamey protocol. A single stool sample was obtained from all study participants and examined for S. mansoni using the Kato-Katz technique. The study revealed a high prevalence of S. mansoni (56.3%), and the majority of infected individuals had a light intensity of infection. Ultrasonographic findings revealed that 22.4% of adult individuals had periportal fibrosis (PPF) (grade C-F), with 18.4% having grade C and D and 4% having grade E and F. Males had the highest prevalence of PPF (31.7% vs 10.8%, P<0.001). Organomegaly was common with 28.5% and 29.6% having splenomegaly and hepatomegaly, respectively. S. mansoni infection and its related morbidities included PPF, hepatomegaly, and splenomegaly were common among adult individuals. To reduce the level of transmission of S. mansoni infection, planned mass drug administration campaigns should include adult individuals living in these villages.
참고문헌 (37)
- Mazigo HD, "Epidemiology and control of human schistosomiasis in Tanzania", Parasit Vectors, 5, pp.274~ (2012)
- Rollinson D, "Time to set the agenda for schistosomiasis elimination", Acta Trop, 128, pp.423~440 (2013)
- Brooker S, "An updated atlas of human helminth infections: the example of East Africa", Int. J Health Geogr, 8, pp.42~ (2009)
- Kardorff R, "Schistosoma mansoni-related morbidity on Ukerewe Island, Tanzania: clinical, ultrasonographical and biochemical parameters", Trop Med Int Health, 2, pp.230~239 (1997)
- Malenganisho WL, "Schistosoma mansoni morbidity among adults in two villages along Lake Victoria shores in Mwanza district, Tanzania", Trans R Soc Trop Med Hyg, 102, pp.532~541 (2008)
- Mazigo HD, "Periportal fibrosis, liver and spleen sizes among S. mansoni mono or co-infected individuals with human immunodeficiency virus-1 in fishing villages along Lake Victoria shores, North-Western, Tanzania", Parasit Vectors, 8, pp.260~ (2015)
- Godfrey M. Kaatano, "Schistosoma mansoni-Related Hepatosplenic Morbidity in Adult Population on Kome Island, Sengerema District, Tanzania", The Korean Journal of Parasitology, 53(5), pp.545~552 (2015), 대한기생충학ㆍ열대의학회
- Booth M, "Hepatosplenic morbidity in two neighbouring communities in Uganda with high levels of Schistosoma mansoni infection but very different durations of residence", Trans R Soc Trop Med Hyg, 98, pp.125~136 (2004)
- WHO Expert Committee, "Prevention and control of schistosomiasis and soil-transmitted helminthiasis", World Health Organ Tech Rep Ser, 912, pp.1~57 (2002)
- Eliminating soil-transmitted helminthiases as a public health problem in children: progress report 2001-2010 and strategic plan 2011-2020. 2012, "World Health Organisation", World Health Organ, ~ (2012)
- de Clercq D, "The relationship between Schistosoma haematobium infection and school performance and attendance in Bamako, Mali", Ann Trop Med Parasitol, 92, pp.851~858 (1998)
- Jukes MC, "Heavy schistosomiasis associated with poor short-term memory and slower reaction times in Tanzanian schoolchildren", Trop Med Int Health, 7, pp.104~117 (2002)
- Njenga SM, "Adult population as potential reservoir of NTD infections in rural villages of Kwale district, Coastal Kenya: implications for preventive chemotherapy interventions policy", Parasit Vectors, 4, pp.175~ (2011)
- Halwindi H, "Potential contribution of adult populations to the maintenance of schistosomiasis and soil-transmitted helminth infections in the Siavonga and Mazabuka districts of Zambia", J Biosoc Sci, 2016, pp.1~11 (2016)
- Munisi DZ, "Intestinal schistosomiasis among primary schoolchildren in two on-shore communities in Rorya district, northwestern Tanzania: prevalence, intensity of infection and associated risk factors", J Parasitol Res, 2016, pp.1859737~ (2016)
- Tanzania national population and housing census, 2012, "National Bureau of Statistics", ~ (2012)
- Mazigo HD, "Co-infection with Schistosoma mansoni and human immunodeficiency virus-1(HIV-1) among residents of fishing villages of north-western Tanzania", Parasit Vectors, 7, pp.587~ (2014)
- Montresor A, "Large-scale preventive chemotherapy for the control of helminth infection in Western Pacific countries: six years later", PLoS Negl Trop Dis, 2, pp.e278~ (2008)
- Katz N, "A simple device for quantitative stool thick-smear technique in Schistosomiasis mansoni", Rev Inst Med Trop São Paulo, 14, pp.397~400 (1972)
- Yazdanpanah Y, "Organometric investigations of the spleen and liver by ultrasound in Schistosoma mansoni endemic and nonendemic villages in Senegal", Am J Trop Med Hyg, 57, pp.245~249 (1997)
- Richter J, "Ultrasound in schistosomiasis: a practical guide to the standard use of ultrasonography for assessment of schistosomiasis-related morbidity", Second international workshop (2000), Tropical Diseases Research, World Health Organization
- Mazigo HD, "Co-infections with Plasmodium falciparum, Schistosoma mansoni and intestinal helminths among schoolchildren in endemic areas of northwestern Tanzania", Parasit Vectors, 3, pp.44~ (2010)
- Lwambo NJ, "Patterns of concurrent hookworm infection and schistosomiasis in schoolchildren in Tanzania", Trans R Soc Trop Med Hyg, 93, pp.497~502 (1999)
- Magendantz M, "The biology of Biomphalaria choanomphala and B. sudanica in relation to their role in the transmission of Schistosoma mansoni in Lake Victoria at Mwanza, Tanzania", Bull World Health Organ, 47, pp.331~341 (1972)
- Kabatereine NB, "Schistosoma mansoni along Lake Albert, Kibale District, western Uganda", East Afr Med J, 73, pp.502~504 (1996)
- Scott JT, "Human water contacts patterns in Schistosoma mansoni epidemic foci in northern Senegal change according to age, sex and place of residence, but are not related to intensity of infection", Trop Med Int Health, 8, pp.100~108 (2003)
- Gazzinelli A, "Exposure to Schistosoma mansoni infection in a rural area of Brazil. I. Water contact", Trop Med Int Health, 6, pp.126~135 (2001)
- Boisier P, "Geographic differences in hepatosplenic complications of schistosomiasis mansoni and explanatory factors of morbidity", Trop Med Int Health, 6, pp.699~706 (2001)
- Guyatt H, "Assessing the public health importance of Schistosoma mansoni in different endemic areas : attributable fraction estimates as an approach", Am J Trop Med Hyg, 53, pp.660~667 (1995)
- Butler JR, "Demography and human-dog relationships of the dog population in Zimbabwe communal lands", Vet Rec, 147, pp.442~446 (2000)
- Butterworth AE, "Immunity and morbidity in human schistosomiasis mansoni", Trop Geogr Med, 46, pp.197~208 (1994)
- Gryseels B, "The morbidity of schistosomiasis mansoni in Maniema (Zaire)", Trans R Soc Trop Med Hyg, 81, pp.202~209 (1987)
- Gryseels B, "Morbidity, due to schistosomiasis mansoni, and its control in Subsaharan Africa", Parasitol Today, 7, pp.244~248 (1991)
- Boisier P, "Ultrasonographical assessment of morbidity in schistosomiasis mansoni in Madagascar : a community-based study in a rural population", Trans R Soc Trop Med Hyg, 89, pp.208~212 (1995)
- Barakat R, "The epidemiology of schistosomiasis in Egypt: patterns of Schistosoma mansoni infection and morbidity in Kafer El-Sheikh", Am J Trop Med Hyg, 62(suppl), pp.21~27 (2000)
- Brooker S, "Human hookworm infection in the 21st century", Adv Parasitol, 58, pp.197~288 (2004)
- Mohamed-Ali Q, "Susceptibility to periportal (Symmers) fibrosis in human Schistosoma mansoni infections: evidence that intensity and duration of infection, gender, and inherited factors are critical in disease progression", J Infect Dis, 180, pp.1298~1306 (1999)