The Effect of ABO Blood Groups, Hemoglobinopathy, and Heme Oxygenase-1 Polymorphisms on Malaria Susceptibility and Severity
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Malaria is one of the most important public health problems in tropical areas on the globe. Several factors are associated with susceptibility to malaria and disease severity, including innate immunity such as blood group, hemoglobinopathy, and heme oxygenase-1 (HO-1) polymorphisms. This study was carried out to investigate association among ABO blood group, thalassemia types and HO-1 polymorphisms in malaria. The malarial blood samples were collected from patients along the Thai-Myanmar border. Determination of ABO blood group, thalassemia variants, and HO-1 polymorphisms were performed using agglutination test, low pressure liquid chromatography and polymerase chain reaction, respectively. Plasmodium vivax was the major infected malaria species in the study samples. Distribution of ABO blood type in the malaria-infected samples was similar to that in healthy subjects, of which blood type O being most prevalent. Association between blood group A and decreased risk of severe malaria was significant. Six thalassemia types (30%) were detected, i.e., hemoglobin E (HbE), β-thalassemia, α-thalassemia 1, α-thalassemia 2, HbE with α-thalassemia 2, and β-thalassemia with α-thalassemia 2. Malaria infected samples without thalassemia showed significantly higher risk to severe malaria. The prevalence of HO-1 polymorphisms, S/S, S/L and L/L were 25, 62, and 13%, respectively. Further study with larger sample size is required to confirm the impact of these 3 host genetic factors in malaria patients.
Abstract
Malaria is one of the most important public health problems in tropical areas on the globe. Several factors are associated with susceptibility to malaria and disease severity, including innate immunity such as blood group, hemoglobinopathy, and heme oxygenase-1 (HO-1) polymorphisms. This study was carried out to investigate association among ABO blood group, thalassemia types and HO-1 polymorphisms in malaria. The malarial blood samples were collected from patients along the Thai-Myanmar border. Determination of ABO blood group, thalassemia variants, and HO-1 polymorphisms were performed using agglutination test, low pressure liquid chromatography and polymerase chain reaction, respectively. Plasmodium vivax was the major infected malaria species in the study samples. Distribution of ABO blood type in the malaria-infected samples was similar to that in healthy subjects, of which blood type O being most prevalent. Association between blood group A and decreased risk of severe malaria was significant. Six thalassemia types (30%) were detected, i.e., hemoglobin E (HbE), β-thalassemia, α-thalassemia 1, α-thalassemia 2, HbE with α-thalassemia 2, and β-thalassemia with α-thalassemia 2. Malaria infected samples without thalassemia showed significantly higher risk to severe malaria. The prevalence of HO-1 polymorphisms, S/S, S/L and L/L were 25, 62, and 13%, respectively. Further study with larger sample size is required to confirm the impact of these 3 host genetic factors in malaria patients.
참고문헌 (34)
- Stevenson M, "Innate immunity to malaria", Nat Rev Immunol, 4, pp.169~180 (2004)[DOI]
- Weatherall DJ, "Thalassaemia and malaria, revisited", Ann Trop Med Parasitol, 91, pp.885~890 (1997)[DOI]
- Takeda M, "Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to cerebral malaria in Myanmar", Jpn J Infect Dis, 58, pp.268~271 (2005)
- Kuesap J, "Study on association between genetic polymorphisms of haem oxygenase-1, tumour necrosis factor, cadmium exposure and malaria pathogenicity and severity", Malar J, 9, pp.260~ (2010)[DOI]
- Campino S, "Mendelian and complex genetics of susceptibility and resistance to parasitic infections", Semin Immunol, 18, pp.411~422 (2006)[DOI]
- Allison AC, "Protection afforded by sickle cell trait against subtertian malarial infection", Br Med J, 1, pp.290~294 (1954)[DOI]
- Martin SK, "Frequency of blood group antigens in Nigerian children with falciparum malaria", Trans R Soc Trop Med Hyg, 73, pp.216~318 (1979)[DOI]
- Fischer PR, "Short report: severe malaria associated with blood group", Am J Trop Med Hyg, 58, pp.122~123 (1998)[DOI]
- Lell B, "The role of red blood cell polymorphisms in resistance and susceptibility to malaria", Clin Infect Dis, 28, pp.794~799 (1999)[DOI]
- Tekeste Z, "The ABO blood group and Plasmodium falciparum malaria in Awash, Metehara and Ziway areas, Ethiopia", Malar J, 9, pp.280~ (2010)[DOI]
- Pathirana SL, "ABO-bloodgroup types and protection against severe, Plasmodium falciparum malaria", Ann Trop Med Parasitol, 99, pp.119~124 (2005)[DOI]
- Rowe JA, "Blood group O protects against severe Plasmodium falciparum malaria through the mechanism of reduced rosetting", Proc Natl Acad Sci USA, 104, pp.17471~17476 (2007)[DOI]
- Panda AK, "Association of ABO blood group with severe falciparum malaria in adults: case control study and meta-analysis", Malar J, 10, pp.309~ (2011)[DOI]
- Rout R, "Blood group phenotypes A and B are risk factors for cerebral malaria in Odisha, India", Trans R Soc Trop Med Hyg, 106, pp.538~543 (2012)[DOI]
- Resende SS, "Increased susceptibility of blood type O individuals to develop anemia in Plasmodium vivax infection", Infect Genet Evol, 50, pp.87~92 (2017)[DOI]
- Vento S, "Infections and thalassaemia", Lancet Infect Dis, 6, pp.226~233 (2006)[DOI]
- Chotivanich K, "Hemoglobin E: a balanced polymorphism protective against high parasitemias and thus severe P. falciparum malaria", Blood, 100, pp.1172~1176 (2002)
- Wambua S, "The effect of alpha+-thalassaemia on the incidence of malaria and other diseases in children living on the coast of Kenya", PLoS Med, 3, pp.643~651 (2006)
- Pasvol G, "Fetal haemoglobin and malaria", Lancet, 1, pp.1269~1272 (1976)
- Pantaleo A, "Effect of heterozygous beta thalassemia on the phosphorylative response to Plasmodium falciparum infection", J Proteomics, 76, pp.251~258 (2012)[DOI]
- Walther M, "HMOX1 gene promoter alleles and high HO-1 levels are associated with severe malaria in Gambian children", PLoS Pathog, 8, pp.e1002579~ (2012)[DOI]
- Clark IA, "Induction of HO-1 in tissue macrophages and monocytes in fatal falciparum malaria and sepsis", Malar J, 2, pp.41~ (2003)[DOI]
- Sambo MR, "Transforming growth factor beta 2 and heme oxygenase 1 genes are risk factors for the cerebral malaria syndrome in Angolan children", PLoS One, 5, pp.e11141~ (2010)[DOI]
- Shibahara S, "The heme oxygenase dilemma in cellular homeostasis: new insights for the feedback regulation of heme catabolism", Tohoku J Exp Med, 200, pp.167~186 (2003)[DOI]
- Fucharoen S, "Thalassemia and abnormal haemoglobin", Int J Hematol, 76(suppl), pp.83~89 (2002)[DOI]
- Nagel RL, "Impairment of the growth of P. falciparum in HbEE erythrocytes", J Clin Invest, 68, pp.303~305 (1981)[DOI]
- World Health Organization, "Haemoglobin Concentrations for the Diagnosis of Anaemia and Assessment of Severity", World Health Organization, ~ (2011)
- World Health Organization, "Guidelines for the Treatment of Malaria", World Health Organization, 35~ (2010)
- Fu WP, "Heme oxygenase-1 polymorphism associated with severity of chronic obstructive pulmonary disease", Chin Med J, 120, pp.12~16 (2007)
- Chandanayingyong D, "Blood groups of the Thais", Transfusion, 7, pp.269~276 (1967)[DOI]
- Nathalang O, "A preliminary study of the distribution of blood group systems in Thai blood donors determined by the gel test", Southeast Asian J Trop Med Public Health, 32, pp.204~207 (2001)
- Palacajornsuk P, "Screening of ABO, Rh typing and unexpected alloantibodies in pregnant women attending antenatal care at Sriphat Medical Center, Faculty of Medicine, Chiang Mai University", J Assoc Med Sci, 50, pp.153~158 (2017)
- Fucharoen S, "Hemoglobinopathies in Southeast Asia", Hemoglobin, 11, pp.65~88 (1987)[DOI]
- Shibahara S, "Heme degradation and human disease: diversity is the soul of life", Antioxid Redox Signal, 4, pp.593~602 (2002)[DOI]