National Estimates of Narcolepsy in Korea
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Background and Purpose Epidemiological data on narcolepsy are rare in South Korea. We aimed to provide an overview of the burden of narcolepsy and its temporal trend in South Korea. Methods Patients with narcolepsy were identified by their registration in the Rare and Intractable Disease (RID) register and the Health Insurance Review and Assessment database. Individuals registered in the RID program with the code V234 were considered as having ‘definite narcolepsy’, while those who claimed health insurance with G47.4 as the primary diagnostic code were considered as having ‘probable narcolepsy’. We estimated the annual prevalence, incidence, and medical costs of narcolepsy between 2010 and 2019. Results The prevalence of definite narcolepsy was 8.4/100,000 in 2019, peaking at 32.0/100,000 in those aged 15–19 years. The prevalence was higher in males, with a relative risk of 1.72. The prevalence has increased over the past 6 years, with an average annual growth rate (AAGR) of 12.2%. The prevalence of probable narcolepsy was 10.7/100,000 in 2019. The incidence of definite narcolepsy increased up to 1.3/100,000 in 2019 with an AAGR of 7.1%. Annual medical expenditure for definite narcolepsy gradually increased up to 4.1 billion KRW in 2019, with a compound annual growth rate of 11.9%. Conclusions This study has provided the first nationwide estimates for narcolepsy in South Korea. The prevalence of diagnosed narcolepsy in South Korea was at the low end of the range of narcolepsy prevalence rates reported for other countries. However, the prevalence and incidence have been steadily increasing over the past decade.
Abstract
Background and Purpose Epidemiological data on narcolepsy are rare in South Korea. We aimed to provide an overview of the burden of narcolepsy and its temporal trend in South Korea. Methods Patients with narcolepsy were identified by their registration in the Rare and Intractable Disease (RID) register and the Health Insurance Review and Assessment database. Individuals registered in the RID program with the code V234 were considered as having ‘definite narcolepsy’, while those who claimed health insurance with G47.4 as the primary diagnostic code were considered as having ‘probable narcolepsy’. We estimated the annual prevalence, incidence, and medical costs of narcolepsy between 2010 and 2019. Results The prevalence of definite narcolepsy was 8.4/100,000 in 2019, peaking at 32.0/100,000 in those aged 15–19 years. The prevalence was higher in males, with a relative risk of 1.72. The prevalence has increased over the past 6 years, with an average annual growth rate (AAGR) of 12.2%. The prevalence of probable narcolepsy was 10.7/100,000 in 2019. The incidence of definite narcolepsy increased up to 1.3/100,000 in 2019 with an AAGR of 7.1%. Annual medical expenditure for definite narcolepsy gradually increased up to 4.1 billion KRW in 2019, with a compound annual growth rate of 11.9%. Conclusions This study has provided the first nationwide estimates for narcolepsy in South Korea. The prevalence of diagnosed narcolepsy in South Korea was at the low end of the range of narcolepsy prevalence rates reported for other countries. However, the prevalence and incidence have been steadily increasing over the past decade.
참고문헌 (22)
- Kornum BR, "Narcolepsy", Nat Rev Dis Primers, 3, pp.16100~ (2017)
- Broughton WA, "Psychosocial impact of narcolepsy", Sleep, 17(8 Suppl), pp.S45~S49 (1994)
- Wing YK, "The prevalence of narcolepsy among Chinese in Hong Kong", Ann Neurol, 51, pp.578~584 (2002)
- Dauvilliers Y, "Narcolepsy with cataplexy", Lancet, 369, pp.499~511 (2007)
- Hublin C, "The prevalence of narcolepsy : an epidemiological study of the Finnish Twin Cohort", Ann Neurol, 35, pp.709~716 (1994)
- Longstreth WT Jr, "The epidemiology of narcolepsy", Sleep, 30, pp.13~26 (2007)
- Silber MH, "The epidemiology of narcolepsy in Olmsted County, Minnesota : a population-based study", Sleep, 25, pp.197~202 (2002)
- Heier MS, "Prevalence of narcolepsy with cataplexy in Norway", Acta Neurol Scand, 120, pp.276~280 (2009)
- Ohayon MM, "Prevalence of narcolepsy symptomatology and diagnosis in the European general population", Neurology, 58, pp.1826~1833 (2002)
- Wijnans L, "The incidence of narcolepsy in Europe : before, during, and after the influenza A(H1N1)pdm09 pandemic and vaccination campaigns", Vaccine, 31, pp.1246~1254 (2013)
- Szakács A, "Increased childhood incidence of narcolepsy in western Sweden after H1N1 influenza vaccination", Neurology, 80, pp.1315~1321 (2013)
- Oberle D, "Incidence of narcolepsy in Germany", Sleep, 38, pp.1619~1628 (2015)
- Partinen M, "Increased incidence and clinical picture of childhood narcolepsy following the 2009 H1N1 pandemic vaccination campaign in Finland", PLoS One, 7, pp.e33723~ (2012)
- Han F, "Narcolepsy onset is seasonal and increased following the 2009 H1N1 pandemic in China", Ann Neurol, 70, pp.410~417 (2011)
- 성민재, "기면병 환자에서 다중수면잠복기검사의 검사-재검사 신뢰도 검증", Journal of sleep medicine, 17(2), pp.175~180 (2020), 대한수면연구학회[DOI]
- Shin YK, "Prevalence of narcolepsy-cataplexy in Korean adolescents", Acta Neurol Scand, 117, pp.273~278 (2008)
- Choe YJ, "No association between influenza A(H1N1)pdm09 vaccination and narcolepsy in South Korea : an ecological study", Vaccine, 30, pp.7439~7442 (2012)
- Lim SS, "The cumulative incidence and trends of rare diseases in South Korea : a nationwide study of the administrative data from the National Health Insurance Service database from 2011-2015", Orphanet J Rare Dis, 14, pp.49~ (2019)
- Billiard M, "Excessive daytime somnolence in young men : prevalence and contributing factors", Sleep, 10, pp.297~305 (1987)
- Feketeova E, "Narcolepsy in Slovakia–Epidemiology, clinical and polysomnographic features, comorbid diagnoses : a case-control study", Sleep Med, 67, pp.15~22 (2020)
- Dauvilliers Y, "Age at onset of narcolepsy in two large populations of patients in France and Quebec", Neurology, 57, pp.2029~2033 (2001)
- Thorpy MJ, "Delayed diagnosis of narcolepsy : characterization and impact", Sleep Med, 15, pp.502~507 (2014)