Clinical Characteristics, Comorbidities, and Quality of Life in Korean Patients With Narcolepsy: Findings From an Online Survey
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Objectives: Narcolepsy is a chronic neurological disorder characterized by excessive daytime sleepiness and abnormal rapid eye movement sleep, both of which significantly impact daily functioning and quality of life. This study aimed to examine the clinical characteristics, comorbidities, diagnostic delays, and quality of life of Korean patients with narcolepsy through a comprehensive nationwide survey.Methods: An online survey targeting members of the Korea Narcolepsy Association was conducted between July and October 2023. The survey collected demographic information, clinical characteristics, comorbid conditions, diagnostic tools, and quality of life assessments using the World Health Organization Quality of Life-BREF (WHOQOL-BREF).Results: A total of 299 individuals participated in the study, with a mean age of 32.2 years. The average diagnostic delay was approximately 11 years, with initial symptoms appearing at a mean age of 16.6 years. Excessive daytime sleepiness was the most common initial symptom. The most frequent comorbidities included depression, obstructive sleep apnea, and anxiety disorders. WHOQOL-BREF scores indicated a moderately low quality of life across all domains, with patients having narcolepsy type 1 experiencing more severe symptoms and lower quality of life scores than those of patients having narcolepsy type 2. Higher education levels, marital status, and regular exercise were positively associated with better WHOQOL-BREF scores, whereas depression, older age, and poor sleep quality were negatively associated.Conclusions: The findings from this survey underscore the lower quality of life, with notable delays in diagnosis and a high prevalence of comorbid conditions. The results suggest a need for improved awareness, timely diagnosis, and comprehensive management strategies that address both the primary symptoms of narcolepsy and its associated comorbidities.
Abstract
Objectives: Narcolepsy is a chronic neurological disorder characterized by excessive daytime sleepiness and abnormal rapid eye movement sleep, both of which significantly impact daily functioning and quality of life. This study aimed to examine the clinical characteristics, comorbidities, diagnostic delays, and quality of life of Korean patients with narcolepsy through a comprehensive nationwide survey.Methods: An online survey targeting members of the Korea Narcolepsy Association was conducted between July and October 2023. The survey collected demographic information, clinical characteristics, comorbid conditions, diagnostic tools, and quality of life assessments using the World Health Organization Quality of Life-BREF (WHOQOL-BREF).Results: A total of 299 individuals participated in the study, with a mean age of 32.2 years. The average diagnostic delay was approximately 11 years, with initial symptoms appearing at a mean age of 16.6 years. Excessive daytime sleepiness was the most common initial symptom. The most frequent comorbidities included depression, obstructive sleep apnea, and anxiety disorders. WHOQOL-BREF scores indicated a moderately low quality of life across all domains, with patients having narcolepsy type 1 experiencing more severe symptoms and lower quality of life scores than those of patients having narcolepsy type 2. Higher education levels, marital status, and regular exercise were positively associated with better WHOQOL-BREF scores, whereas depression, older age, and poor sleep quality were negatively associated.Conclusions: The findings from this survey underscore the lower quality of life, with notable delays in diagnosis and a high prevalence of comorbid conditions. The results suggest a need for improved awareness, timely diagnosis, and comprehensive management strategies that address both the primary symptoms of narcolepsy and its associated comorbidities.
참고문헌 (26)
- Bassetti CLA, "Narcolepsy-clinical spectrum, aetiopathophysiology, diagnosis and treatment", Nat Rev Neurol, 15, pp.519~539 (2019)[DOI]
- Thorpy MJ, "Narcolepsy: a clinical guide", pp.45~49 (2016), Springer
- Zhang Z, "Idling for decades : a European study on risk factors associated with the delay before a narcolepsy diagnosis", Nat Sci Sleep, 14, pp.1031~1047 (2022)[DOI]
- Park HR, "National estimates of narcolepsy in Korea", J Clin Neurol, 19, pp.83~89 (2023)[DOI]
- Cho YW, "The reliability and validity of the Korean version of the Epworth sleepiness scale", Sleep Breath, 15, pp.377~384 (2011)[DOI]
- Sohn SI, "The reliability and validity of the Korean version of the Pittsburgh sleep quality index", Sleep Breath, 16, pp.803~812 (2012)[DOI]
- Shahid A, "STOP, THAT and one hundred other sleep scales", pp.395~396 (2011), Springer
- Min SK, "Development of the Korean versions of WHO quality of life scale and WHOQOL-BREF", Qual Life Res, 11, pp.593~600 (2002)[DOI]
- The WHOQOL Group, "Development of the World Health Organization WHOQOL-BREF quality of life assessment", Psychol Med, 28, pp.551~558 (1998)[DOI]
- Lee MJ, "Comorbidity of narcolepsy and depressive disorders : a nationwide population-based study in Taiwan", Sleep Med, 39, pp.95~100 (2017)[DOI]
- Cohen A, "Comorbidities in a community sample of narcolepsy", Sleep Med, 43, pp.14~18 (2018)[DOI]
- Alasim H, "Comorbid psychiatric disorders among patients with narcolepsy", Sleep Breath, 24, pp.629~636 (2020)[DOI]
- Yeh JY, "Comorbidity of narcolepsy and psychotic disorders : a nationwide population-based study in Taiwan", Front Psychiatry, 11, pp.205~ (2020)[DOI]
- Ohayon MM, "Narcolepsy is complicated by high medical and psychiatric comorbidities : a comparison with the general population", Sleep Med, 14, pp.488~492 (2013)[DOI]
- Plazzi G, "Restless legs syndrome is frequent in narcolepsy with cataplexy patients", Sleep, 33, pp.689~694 (2010)[DOI]
- Ferri R, "Different periodicity and time structure of leg movements during sleep in narcolepsy", cataplexy and restless legs syndrome, 2006, pp.29, 1587~1594
- Taddei RN, "Diagnostic delay in narcolepsy type 1 : combining the patients’ and the doctors’ perspectives", J Sleep Res, 25, pp.709~715 (2016)[DOI]
- Bhattarai J, "Diagnostic delay of narcolepsy : contributing factors and implications for clinicians", Sleep Vigilance, 2, pp.103~109 (2018)[DOI]
- Thorpy MJ, "Delayed diagnosis of narcolepsy : characterization and impact", Sleep Med, 15, pp.502~507 (2014)[DOI]
- Dodel R, "Health-related quality of life in patients with narcolepsy", Sleep Med, 8, pp.733~741 (2007)[DOI]
- Tadrous R, "Health-related quality of life in narcolepsy : a systematic review and meta-analysis", J Sleep Res, 30, pp.e13383~ (2021)[DOI]
- Song ML, "The influential factor of narcolepsy on quality of life : compared to obstructive sleep apnea with somnolence or insomnia", Sleep Biol Rhythms, 17, pp.447~454 (2019)[DOI]
- Goswami M, "The influence of clinical symptoms on quality of life in patients with narcolepsy", Neurology, 50(2 Suppl 1), pp.S31~S36 (1998)[DOI]
- Vignatelli L, "Health-related quality of life in Italian patients with narcolepsy : the SF-36 health survey", Sleep Med, 5, pp.467~475 (2004)[DOI]
- Chin WC, "Quality of life changes and their predictors in young adult narcolepsy patients after treatment : a realworld cohort study", Front Psychiatry, 13, pp.956037~ (2022)[DOI]
- Cho JW, "Comparison of health related quality of life between type I and type II narcolepsy patients", J Sleep Med, 13, pp.46~52 (2016)[DOI]