Prevalence of Neuromuscular Diseases in Young South Korean Males; A Korean Military Manpower Administration and Medical Command Data-Based Study
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Background and Purpose All young males in South Korea must undergo a physical examination for their participation in military service. We aimed to determine the prevalence rate (PR) of various neuromuscular diseases in young South Korean males using the data of exempted patients and soldiers. Methods The number of males exempted based on specific items of physical examination corresponding to neuromuscular disease during 2011–2020 were obtained from the records of the Military Manpower Administration. The list of enlisted soldier patients who were discharged from military service due to neuromuscular diseases during 2011–2020 was obtained from the Armed Forces Medical Command, and their medical records were reviewed. Results The PR of neuromuscular diseases was calculated among 948 identified males: 713 exempted males and 235 soldiers. The PRs of overall hereditary neuropathies, Hirayama disease (HD), myasthenia gravis (MG), and inherited muscle diseases in South Korean males in their early 20s were 8.34 (95% confidence interval [CI], 7.39–9.30), 5.54 (95% CI, 4.76–6.32), 2.97 (95% CI, 2.40–3.55), and 10.38 (95% CI, 9.31–11.46) per 100,000 persons, respectively. Among the enlisted soldiers, hereditary neuropathy with liability to pressure palsy was the most common neuromuscular disease, with a prevalence among the enlisted soldiers of 3.11 (95% CI, 2.42–3.80) per 100,000 persons. Myotonic dystrophy was the most prevalent myopathy, followed by facioscapulohumeral muscular dystrophy. Conclusions The 10-year PRs of hereditary polyneuropathies, HD, MG, and inherited muscle diseases in young South Korean males have been reported. These data could be valuable to understanding each neuromuscular disease in the young male population of South Korea.
Abstract
Background and Purpose All young males in South Korea must undergo a physical examination for their participation in military service. We aimed to determine the prevalence rate (PR) of various neuromuscular diseases in young South Korean males using the data of exempted patients and soldiers. Methods The number of males exempted based on specific items of physical examination corresponding to neuromuscular disease during 2011–2020 were obtained from the records of the Military Manpower Administration. The list of enlisted soldier patients who were discharged from military service due to neuromuscular diseases during 2011–2020 was obtained from the Armed Forces Medical Command, and their medical records were reviewed. Results The PR of neuromuscular diseases was calculated among 948 identified males: 713 exempted males and 235 soldiers. The PRs of overall hereditary neuropathies, Hirayama disease (HD), myasthenia gravis (MG), and inherited muscle diseases in South Korean males in their early 20s were 8.34 (95% confidence interval [CI], 7.39–9.30), 5.54 (95% CI, 4.76–6.32), 2.97 (95% CI, 2.40–3.55), and 10.38 (95% CI, 9.31–11.46) per 100,000 persons, respectively. Among the enlisted soldiers, hereditary neuropathy with liability to pressure palsy was the most common neuromuscular disease, with a prevalence among the enlisted soldiers of 3.11 (95% CI, 2.42–3.80) per 100,000 persons. Myotonic dystrophy was the most prevalent myopathy, followed by facioscapulohumeral muscular dystrophy. Conclusions The 10-year PRs of hereditary polyneuropathies, HD, MG, and inherited muscle diseases in young South Korean males have been reported. These data could be valuable to understanding each neuromuscular disease in the young male population of South Korea.
참고문헌 (22)
- Horowitz SH, "Hereditary neuropathy with liability to pressure palsy : fulminant development with axonal loss during military training", J Neurol Neurosurg Psychiatry, 75, pp.1629~1631 (2004)
- Delacour H, "Hereditary neuropathy with liability to pressure palsies occurring during military training", J R Army Med Corps, 158, pp.47~49 (2012)
- Kim KE, "Proximal arm weakness is the most common presentation in young Korean soldiers diagnosed as having hereditary neuropathy with liability to pressure palsy(HNPP)", J R Army Med Corps, 162, pp.352~354 (2016)
- Mäkelä JP, "Myotonias and army personnel : symptoms and effects on service fitness", Mil Med, 170, pp.806~809 (2005)
- Lefter S, "A population-based epidemiologic study of adult neuromuscular disease in the Republic of Ireland", Neurology, 88, pp.304~313 (2017)
- Meretoja P, "Epidemiology of hereditary neuropathy with liability to pressure palsies(HNPP)in south western Finland", Neuromuscul Disord, 7, pp.529~532 (1997)
- Foley C, "Charcot-Marie-Tooth disease in Northern England", J Neurol Neurosurg Psychiatry, 83, pp.572~573 (2012)
- Park JE, "Frequency of hereditary neuropathy with liability to pressure palsies(HNPP)due to 17p11. 2 deletion in a Korean newborn population", Orphanet J Rare Dis, 13, pp.40~ (2018)
- Kim KE, "Characteristic features of hereditary neuropathy with liability to pressure palsy(HNPP)presenting with brachial plexopathy in soldiers", J Neurol Sci, 346, pp.174~177 (2014)
- Deenen JC, "The epidemiology of neuromuscular disorders : a comprehensive overview of the literature", J Neuromuscul Dis, 2, pp.73~85 (2015)
- Park HJ, "Prevalence, mortality, and cause of death in Charcot-Marie-Tooth disease in Korea : a nationwide, population-based study", Neuroepidemiology, 54, pp.313~319 (2020)
- Tashiro K, "Nationwide survey of juvenile muscular atrophy of distal upper extremity(Hirayama disease)in Japan", Amyotroph Lateral Scler, 7, pp.38~45 (2006)
- Wang H, "Update on the pathogenesis, clinical diagnosis, and treatment of Hirayama disease", Front Neurol, 12, pp.811943~ (2021)
- 권오현, "A Korean Case of Juvenile Muscular Atrophy of Distal Upper Extremity (Hirayama Disease) with Dynamic Cervical Cord Compression", Journal of Korean Medical Science, 19(5), pp.768~771 (2004), 대한의학회
- 유승돈, "Monomelic Amyotrophy (Hirayama Disease) With Upper Motor Neuron Signs: A Case Report", Annals of Rehabilitation Medicine, 39(1), pp.122~127 (2015), 대한재활의학회
- 이경희, "Clinical Experiences of Uncommon Motor Neuron Disease: Hirayama Disease", Neurospine, 13(3), pp.170~172 (2016), 대한척추신경외과학회[DOI]
- 박수연, "Incidence and Prevalence of Myasthenia Gravis in Korea: A Population-Based Study Using the National Health Insurance Claims Database", Journal of Clinical Neurology, 12(3), pp.340~344 (2016), 대한신경과학회[DOI]
- Zhang X, "Clinical and serological study of myasthenia gravis in HuBei province, China", J Neurol Neurosurg Psychiatry, 78, pp.386~390 (2007)
- Lee HN, "Juvenile myasthenia gravis in Korea : subgroup analysis according to sex and onset age", J Child Neurol, 31, pp.1561~1568 (2016)
- Nakagawa M, "Epidemiology of progressive muscular dystrophy in Okinawa, Japan. Classification with molecular biological techniques", Neuroepidemiology, 10, pp.185~191 (1991)
- 김소연, "한국인 근긴장성 이영양증 제1형 환자의 분자유전학적 및 임상적 특성", Annals of Laboratory Medicine, 28(6), pp.483~492 (2008), 대한진단검사의학회
- Park HJ, "Low D4Z4 copy number and gender difference in Korean patients with facioscapulohumeral muscular dystrophy type 1", Neuromuscul Disord, 25, pp.859~864 (2015)