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Exploring Renal Function Assessment: Creatinine, Cystatin C, and Estimated Glomerular Filtration Rate Focused on the European Kidney Function Consortium Equation

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Serum creatinine and serum cystatin C are the most widely used renal biomarkers for cal- culating the estimated glomerular filtration rate (eGFR), which is used to estimate the se- verity of kidney damage. In this review, we present the basic characteristics of these bio- markers, their advantages and disadvantages, some basic history, and current laboratory measurement practices with state-of-the-art methodology. Their clinical utility is described in terms of normal reference intervals, graphically presented with age-dependent refer- ence intervals, and their use in eGFR equations.

Abstract

Serum creatinine and serum cystatin C are the most widely used renal biomarkers for cal- culating the estimated glomerular filtration rate (eGFR), which is used to estimate the se- verity of kidney damage. In this review, we present the basic characteristics of these bio- markers, their advantages and disadvantages, some basic history, and current laboratory measurement practices with state-of-the-art methodology. Their clinical utility is described in terms of normal reference intervals, graphically presented with age-dependent refer- ence intervals, and their use in eGFR equations.

참고문헌 (54)

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