알러지성 천식 모델 생쥐에서 프랑킨센스 에센셜 오일의 염증 억제 효과
Anti-inflammatory Effect of Boswellia sacra (Franckincense) Essential Oil in a Mouse Model of Allergic Asthma.
1
조회
0
다운로드
3
인용
0
참고문헌
키워드
초록
Frankincense, the gum resin derived from Boswellia species, is complex mixtures composed of about 5~9% highly aromatic essential oil, 65~85% alcohol-soluble resins, and the remaining water-soluble gums. The antiinflammatory properties of frankincense, alcohole-soluble resins, are well-recognized, but the question of whether aromatic essential oil also plays a role in the allergic asthma remains unanswered. This study was performed to evaluate anti-inflammatory effects of Boswellia sacra essential oil (BSEO) on ovalbumin (OVA)-induced asthma mouse model. BALB/c mice after intraperitoneal OVA sensitization were challenged with intratracheal OVA. One experimental group was inhaled with 0.3% BSEO for the later 8 weeks. BALB/c mice were sensitized and challenged with OVA and developed airway eosinophilia, mucus hypersecretion, and airway hyperresponsiveness. In contrast, the BSEO treated mice had reduced a number of eosinophils among BALF cells, goblet cell hyperplasia, and airway hyperresponsiveness. Cytokine analysis of BALF revealed that BSEO caused an increase in Th1 cytokine (interferon-γ (IFN-γ)) and a decrease in Th2 cytokines (interleukin-4 (IL-4), IL-5 and IL-13) levels. In addition, the OVA-specific serum IgE and eotaxin levels were also reduced. In mice inhaled BSEO, CD4+, CD3+/CCR3+, and B220+/CD23+ mediastinal lymph nodes cells were also decreased. These results suggest that inhaled BSEO as a immunomodulator in Th1/Th2 mediated asthma may have therapeutic potential for the treatment in allergic airway inflammation by a simple, cost-effective way.
Abstract
Frankincense, the gum resin derived from Boswellia species, is complex mixtures composed of about 5~9% highly aromatic essential oil, 65~85% alcohol-soluble resins, and the remaining water-soluble gums. The antiinflammatory properties of frankincense, alcohole-soluble resins, are well-recognized, but the question of whether aromatic essential oil also plays a role in the allergic asthma remains unanswered. This study was performed to evaluate anti-inflammatory effects of Boswellia sacra essential oil (BSEO) on ovalbumin (OVA)-induced asthma mouse model. BALB/c mice after intraperitoneal OVA sensitization were challenged with intratracheal OVA. One experimental group was inhaled with 0.3% BSEO for the later 8 weeks. BALB/c mice were sensitized and challenged with OVA and developed airway eosinophilia, mucus hypersecretion, and airway hyperresponsiveness. In contrast, the BSEO treated mice had reduced a number of eosinophils among BALF cells, goblet cell hyperplasia, and airway hyperresponsiveness. Cytokine analysis of BALF revealed that BSEO caused an increase in Th1 cytokine (interferon-γ (IFN-γ)) and a decrease in Th2 cytokines (interleukin-4 (IL-4), IL-5 and IL-13) levels. In addition, the OVA-specific serum IgE and eotaxin levels were also reduced. In mice inhaled BSEO, CD4+, CD3+/CCR3+, and B220+/CD23+ mediastinal lymph nodes cells were also decreased. These results suggest that inhaled BSEO as a immunomodulator in Th1/Th2 mediated asthma may have therapeutic potential for the treatment in allergic airway inflammation by a simple, cost-effective way.
참고문헌 (60)
- Abe, S., "Suppression of tumor necrosis factor-alpha-induced neutrophil adherence responses by essential oils", Med. Inflamm, 12, pp.323~328 (2003)
- Aronica, M. A., "Recall helper T cell response: T helper 1 cell-resistant allergic susceptibility without biasing uncommitted CD4 T cells", Am. J. Respir. Crit. Care Med, 통권 : 169, pp.587~595 (2004)
- Barnes. P. J., "Effect of bbb2-agonist on inflammatory cells", Barnes. P. J, 통권 : 104, pp.10~17 (1999)
- Barnes, P. J., "Therapeutic strategy for allergic disease", Nature, 통권 : 402, pp.B31~38 (1999)
- Barnes, P. J. 2000. Endogenous inhibitor, "Endogenous inhibitory mechanisms in asthma", Am. J. Respir. Crit. Care Med, 통권 : 161, pp.S176~181 (2000)
- Borish, L., "Allergic rhinitis: Systemic inflammation and implications for management", J. Allergy Clin. Immunol, 통권 : 112, pp.1021~1031 (2003)
- Bousquet, J., "Asthma: a disease remodeling the airways", Allergy, 47, pp.3~11 (1992)
- Bousquet, J., "Asthma, From bronchoconstriction to airway inflammation and remodeling", Am. J. Respir. Crit. Care Med, 통권 : 161, pp.1720~1745 (2000)
- Bromberg, J. S. 1993. The biology of CD2, "The biology of CD2: adhesion, transmembrane signal, and regulatory receptor of immunity", J. Surg. Res, 54, pp.258~267 (1993)
- Busse, W. W., "Asthma", N. Engl. J. Med, 344, pp.350~362 (2001)
- Cookson, W., "The alliance of genes and environment in asthma and allergy", Nature, 통권 : 402, pp.B5~11 (1999)
- Coyle, A. J., "IL-4 differentiates naive CD8+ T cells to a “Th2-like" phenotype: a link between viral infections and bronchial asthma", Ann. N. Y. Acad. Sci, 통권 : 796, pp.97~103 (1996)
- Daugherty, B. L., "Cloning, expression, and characterization of the human eosinophil eotaxin receptor", J. Exp. Med, 통권 : 183, pp.2349~2354 (1996)
- de Heer, H. J., "Essential role of lung plasmacytoid dendritic cells in preventing asthmatic reactions to harmless inhaled antigen", J. Exp. Med, 5, pp.89~98 (2004)
- de Sousa, A. C., "Melissa officinalis L. essential oil: antitumoral and antioxidant activities", J. Pharm. Pharmacol, 56, pp.677~681 (2004)
- Duan, W., "Anti-inflammatory effects of mitogen-activated protein kinase kinase inhibitor U0126 in an asthma mouse model", J. Immunol, 통권 : 172, pp.7053~7059 (2004)
- Erin, E. M., "Eotaxin receptor (CCR3) antagonism in asthma and allergic disease", Curr. Drug Targets Inflamm. Allergy, 1, pp.201~214 (2002)
- Foster, P. S., "Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma", J. Exp. Med, 통권 : 183, pp.195~201 (1996)
- Garside, P., "T helper 2 cells are subject to high dose oral tolerance and are not essential for its induction", J. Immunol, 통권 : 154, pp.5649~5655 (1995)
- Gleich, G. J., "Mechanisms of eosinophil-associated inflammation", J. Allergy Clin. Immunol, 통권 : 105, pp.651~663 (2000)
- Gupta, I., "Effect of Boswellia serrata gum resin in patients with bronchial asthma: results of a double blind, placebo-control, 6-week clinical study", Eur. J. Med. Res, 3, pp.511~514 (1998)
- Hajhashemi, V., "Antiinflammatory and analgesic properties of the leaf extracts and essential oil of Lavandula angustifolia Mill", J. Ethnopharmacol, 89, pp.67~71 (2003)
- Hamelmann, E., "Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography", Am. J. Respir. Cirt. Care. Med, 통권 : 156, pp.766~775 (1997)
- Hamm, S., "A chemical investigation by headspace SPME and GC-MS of volatile and semi-volatile terpenes in various olibanum samples", Phytochemistry, 66, pp.1499~1514 (2005)
- Hart, P. H., "Terpinen-4-ol, the main component of the essential oil of Melalecuca alternifolia (tea tree oil), suppresses inflammatory mediator production by activated human monocytes", Hart P. H, 49, pp.619~626 (2000)
- Huang, M. T., "Anti-tumor and anti-carcinogenic acitivity of triterpenoid, beta boswellic acid", Biofactors, 13, pp.225~230 (2000)
- Jain, V. V., "CpG-oligodeoxynucleotides inhibit airway remodeling in a murine model of chronic asthma", J. Allergy Clin. Immunol, 통권 : 110, pp.867~872 (2002)
- Kasakura, S., "A role for T-helper type 1 and type 2 cytokines in the pathogenesis of various human disease", Rinsho. Byori, 46, pp.915~921 (1998)
- Kay, A. B., "Phenotype of cells positive for interleukin-4 and interleukin-5 mRNA in allergic tissue reaction", Int. Arch. Allergy Immunol, 107, pp.208~210 (1995)
- Kibe, A., "Differential regulation by glucocorticoid of interleukin- 13-induced eosinophilia: hyperresponsiveness, and goblet cell hyperplasia in mouse airways", Am. J. Respir. Crit. Care Med, 통권 : 167, pp.50~56 (2003)
- Kim, J., "Inhibition effects of Moutan Cortex Radicis on secretion of eotaxin in A549 humna epithelial cells and eosinophil migration", J. Ethnopharmacol, 통권 : 114, pp.186~193 (2007)
- Kung, T. T., "Mechanisms of allergic pulmonary eosinophilia in the mouse", J. Allergy Clin. Immunol, 94, pp.1217~1224 (1994)
- Larché, M., "The role of T lymphocytes in the pathogenesis of asthma", J. Allergy Clin. Immunol, 통권 : 111, pp.450~463 (2002)
- Makino, S., "Eosinophils and allergy in asthma", Allergy Proc, 16, pp.13~21 (1995)
- Marco, I., "Inhaled iloprost suppresses the cardinal features of asthma via inhibition of airway dendritic cell function", J. Clin. Invest, 통권 : 116, pp.2935~2944 (2006)
- Maruyama, N., "Suppression of neutrophil accumulation in mice by cutaneous application of geranium essential oil", J. Inflamm, 2, pp.1~11 (2005)
- Marx, J., "Effects of Urginea sanguinea, a traditional asthma remedy, on embryo neuronal development", J. Ethnopharmacol, 104, pp.315~321 (2006)
- Palmerio, E. M., "Probability of asthma based on methacholine challenge", Chest, 101, pp.630~633 (1992)
- Paul, J. B., "Desloratadine inhibits allergen-induced airway inflammation and bronchial hyperresponsiveness and alters T-cell responses in murine models of asthma", J. Allergy Clin. Immunol, 통권 : 112, pp.149~159 (2003)
- Ram, A., "Glycyrrhizin alleviates experimental allergic asthma in mice", Int. Immunopharmacol, 6, pp.1468~1477 (2006)
- Redington, A. E., "Airway wall remodeling in asthma", Thorax, 52, pp.310~312
- Robinson, D. S., "Predominant Th2-like bronchoalveolar Tlymphocyte population in atopic asthma", N. Engl. J. Med, 통권 : 326, pp.298~304 (1992)
- Roche, W. R., "Subepithelial fibrosis in the bronchi of asthmatics", Lancet, 1, pp.520~524 (1989)
- Roh, G. S., "Efficacy of a traditional Korean medicine, Chung-Sang-Bo- Ha-Tang, in a murine model of chronic asthma", Int. Immunopharmacol, 5, pp.427~436 (2005)
- Roitt, I. M., "Immunology", pp.11~20 (1989), Gower medical Publishing
- Roy, S., "Human genome screen to identify the genetic basis of the anti-inflammatory effects of Boswellia in microvascular endothelial cells", DNA Cell Biol, 24, pp.244~255 (2005)
- Scola, A. M., "Desensitisation of mast cell beta2- adrenorceptor-mediated responses by salmeterol and formoterol", Br. J. Pharmacol, 통권 : 141, pp.163~171 (2004)
- Sharma, M. L., "Immunomodulatory activity of boswellic acids (pentacyclic triterpene acids) from Boswellia serrata", Phytother. Res, 10, pp.107~112 (1996)
- Singh, G. B., "Anti-inflammatroy actions of boswellic acids", Phytomedicine, 3, pp.81~85 (1996)
- Takami, M., "Effects of DP-1904, a new thromboxane A2 synthetase inhibitor, on guinea pig experimental asthma", Ann. N. Y. Acad. Sc, 통권 : 629, pp.407~409 (1991)
- Takayuki, N., "Anti-allergic acitivity of a Kampho (Japanese herbal) medicine “Sho-seiryu-to (Xiao- Qing-Long-Tang)” on airway inflammation in a mouse model", Int. Immunopharmacol, 4, pp.1353~1365 (2004)
- Taube, C., "The role of IL-13 in established allergic airway disease", J. Immunol, 통권 : 169, pp.6482~6489 (2002)
- To, Y., "Early interleukin 4-dependent response can induce ariway hyperreactivity before development of airway inflammation in a mouse model of asthma", Lab. Invest, 81, pp.1385~1396 (2001)
- Tucker, A. O., "Frankincense and myrrh", Econ. Bot, 40, pp.425~433 (1986)
- van Schayck, C. P., "Potential masking effect on dyspnoea perception by shortand long-acting beta2-agonists in asthma", Eur. Respir. J, 19, pp.240~245 (2002)
- Vignola, A. M., "Airway inflammation in mild intermittent and in persistent asthma", Am. J. Respir. Crit. Care Med, 통권 : 157, pp.403~409 (1998)
- Walker, C., "Allergic and nonallergic asthmatics have distinct patterns of T-cell activation and cytokine production in peripheral blood and bronchoalveloar lavage", Walker C. E. Bode L. Boer T. T. Hansel K. Blaser J. C, 통권 : 146, pp.109~115 (1992)
- Won, J., "Rosmarinic acid inhibits TCR-induced T cell activation and proliferation in an Lck-dependent manner", Eur. J. Immunol, 33, pp.870~879 (2003)
- Yang, M., "Eotaxin-2 and IL-5 cooperate in the lung to regulate IL-13 production and airway eosinophilia and hyperreactivity", J. Allergy. Clin. Immunol, 통권 : 112, pp.935~943 (2003)
- Yang, S. H., "Decreased serum IgE level, decreased IFN-r and IL-5 but increased IL- 10 production, and suppressed cyclooxygenase 2 mRNA expression in patients with perennial allergic rhinitis after treatment with a new mixed formula of Chinese herbs", Int. Immunopharmacol, 1, pp.1173~1182 (2001)
