Antiviral Activity of Gallic Acid against Coxsackievirus B3 and Coxsackievirus B4
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Viral infections are capable of inducing reactive oxygen species (ROS) production in the infected cells and antioxidants have been reported to have antiviral activities against many viruses. In this study, an antiviral assay using the cytopathic effect (CPE) reduction method revealed that gallic acid possesses good anti-coxsackievirus B3 (CB3) and coxsackievirus B4 (CB4) activities, reducing the formation of visible CPE. However, ribavirin did exhibit weak anti-CB3 and CB4 activities and was unable to prevent CPE. Therefore, we conclude that the inhibition of CB3 or CB4 production by gallic acid may be due to its general action as an antioxidant.
Abstract
Viral infections are capable of inducing reactive oxygen species (ROS) production in the infected cells and antioxidants have been reported to have antiviral activities against many viruses. In this study, an antiviral assay using the cytopathic effect (CPE) reduction method revealed that gallic acid possesses good anti-coxsackievirus B3 (CB3) and coxsackievirus B4 (CB4) activities, reducing the formation of visible CPE. However, ribavirin did exhibit weak anti-CB3 and CB4 activities and was unable to prevent CPE. Therefore, we conclude that the inhibition of CB3 or CB4 production by gallic acid may be due to its general action as an antioxidant.
참고문헌 (8)
- Agol VI, "Two types of death of poliovirus-infected cells: caspase involvement in the apoptosis but not cytopathic effect", Virol, 252, pp.343~353 (1998)
- Lok Ranjan Bhatt, "Radical Scavenging Activity of Gallic Acid from Woodfordia Fruticosa Flowers", 동의생리병리학회지, 22(4), pp.903~906 (2008), 한의병리학회
- Choi HJ, "Antiviral activity of quercetin 7-rhamnoside against porcine epidemic diarrhea virus", Antiviral Res, 81, pp.77~81 (2008)
- Gaudernak E, "Antiviral effects of pyrrolidine dithiocarbamate on human rhinoviruses", J. Virol, 76, pp.6004~6015 (2002)
- Jason DG, "Mechanisms of action of ribavirin against distinct viruses", Rev. Med. Virol, 16, pp.37~48 (2006)
- Kaul P, "Rhinovirus induced oxidative stress and interleukin-8 elaboration involves p47-phox but is independent of attachment to intercellular adhesion molecule-1 and viral replication", J. Infect. Dis, 181, pp.1885~1890 (2000)
- Kratz JM, "Anti-HSV-1 and anti-HIV-1activity of gallic acid and pentyl gallate", Mem. Inst. Oswaldo Cruz, 103, pp.437~442 (2008)
- Weiss L, "Anti-hepatitis B virus activity of N-acetyl-L-cysteine (NAC): new aspects of a wellestablished drug", Antiviral Res, 32, pp.43~53 (1996)