실리카겔을 이용한 반코마이신 결정화 시간 단축
The Reduction of Crystal Formation Time of Vancomycin Using Silica Gel
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초록
We investigated the effects of silica gels on the reduction of the crystallization time for the purification of vancomycin. The shortest crystallization time for vancomycin was obtained when silica gel with a pore diameter of 40-60 Å and with a particle diameter of 230-400 mesh was used as the material. The use of silica gel as a surface area increasing material dramatically reduced the crystallization time four fold (6 h) when compared with the results where the surface area had not been similarly increased. In addition, the crystal size of vancomycin was decreased with the addition of silica gel. This improved crystallization process has a significant effect on the convenience and feasibility of the purification step for vancomycin.
Abstract
We investigated the effects of silica gels on the reduction of the crystallization time for the purification of vancomycin. The shortest crystallization time for vancomycin was obtained when silica gel with a pore diameter of 40-60 Å and with a particle diameter of 230-400 mesh was used as the material. The use of silica gel as a surface area increasing material dramatically reduced the crystallization time four fold (6 h) when compared with the results where the surface area had not been similarly increased. In addition, the crystal size of vancomycin was decreased with the addition of silica gel. This improved crystallization process has a significant effect on the convenience and feasibility of the purification step for vancomycin.
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