본문 바로가기
KERD
논문KCI 등재

E형 간염 바이러스에 의한 제 1형 인터페론 신호전달분자 활성 억제

Hepatitis E Virus Inhibits Activation of Signaling Molecules Involved in Induction of Type I Interferon

명진종
한국미생물·생명공학회 (The Korean Society For Microbiology And Biotechnology)|2018.12|한국미생물·생명공학회지 (Microbiology and Biotechnology Letters)|제46권 제4호|pp. 320-325

2

조회

0

다운로드

0

인용

0

참고문헌

키워드

proteaseHepatitis E virustype I interferon
주제분류생물학

초록

E형 간염바이러스는 전세계적으로 매년 2천만건의 감염을 일으키는 것으로 알려져 있다. 흥미로운 것은 임산부에서특히 높은 치사율을 보이는데, 무려 20−30%의 사망률을 보인다는 점이다. 면역능이 있는 감염환자에서는 E형 간염바이러스 감염은 별다른 증상 없이 자연 치유되지만, 면역능이낮은 에이즈환자나 고령환자에서는 만성감염을 일으킬 수도있으며 사망에 이르게 할 수도 있다. 따라서, E형 간염바이러스의 증식억제에 면역반응의 중요성이 높으며, 특히 인터페론 반응이 중요한 역할을 할 것으로 사료된다. 본 연구팀은 E형 간염바이러스의 프로티아제가 RIG-I 의존적 제 1형인터페론 반응을 유의미하게 억제하는 것을 관찰하였다. 또한 바이러스 프로티아제가 RIG-I의 하위 신혼전달 분자의하나인 MAVS의 활성도 농도 의존적으로 억제하는 것으로분석하였다. E형 간염바이러스에 의한 제 1형 인터페론 반응 억제의 구체적인 작용 기작을 밝힌다면 효과적인 항바이러스제제의 개발의 초석을 놓을 수 있을 것으로 기대된다.

Abstract

Hepatitis E virus (HEV) infection accounts for 20 million annual infections worldwide. HEV can be fatal in approximately 20−30% of pregnant women. HEV infections are normally self-limiting and mostly asymptomatic. However, in patients with insufficient immunity, such as acquired immunodeficiency syndrome patients, chronic and often fatal infections may ensue. Therefore, it is likely that host immune responses, especially interferon responses, play a critical role in HEV infection control. Here, we report that an HEVencoded non-structural protein down-regulates type I interferon response. In addition, some other immune genes involved in the induction of type I interferon may be regulated as well. Detailed molecular mechanisms are currently being studied.

참고문헌 (40)

  1. Forni D, "Origin and dispersal of Hepatitis E virus", Emerg. Microbes. Infect, 7, pp.11~ (2018)
  2. Tam AW, "Hepatitis E virus (HEV): molecular cloning and sequencing of the full-length viral genome", Virology, 185, pp.120~131 (1991)
  3. 강상민, "Hepatitis E Virus Methyltransferase Inhibits Type I Interferon Induction by Targeting RIG-I", Journal of Microbiology and Biotechnology, 28(9), pp.1554~1562 (2018), 한국미생물·생명공학회
  4. 강상민, "Host Innate Immunity against Hepatitis E Virus and Viral Evasion Mechanisms", Journal of Microbiology and Biotechnology, 27(10), pp.1727~1735 (2017), 한국미생물·생명공학회
  5. Nari Kim, "Multilayered regulations of RIG-I in the anti-viral signaling pathway", The Journal of Microbiology, 54(9), pp.583~587 (2016), 한국미생물학회[DOI]
  6. Megan E. Schmidt, "Modulation of the host immune response by respiratory syncytial virus proteins", The Journal of Microbiology, 55(3), pp.161~171 (2017), 한국미생물학회[DOI]
  7. Theofilopoulos AN, "Type I interferons (α", β) in immunity and autoimmunity, 2005, pp.23, 307~336
  8. Zitvogel L, "Type I interferons in anticancer immunity", Nat. Rev. Immunol, 15, pp.405~414 (2015)
  9. Loo YM, "Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity", J. Virol, 82, pp.335~345 (2008)
  10. Takeuchi O, "Pattern recognition receptors and inflammation", Cell, 140, pp.805~820 (2010)
  11. Kawai T, "IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction", Nat. Immunol, 6, pp.981~988 (2005)
  12. Seth RB, "Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-κB and IRF 3", Cell, 122, pp.669~682 (2005)
  13. Grandvaux N, "Transcriptional profiling of interferon regulatory factor 3 target genes: direct involvement in the regulation of interferon-stimulated genes", J. Virol, 76, pp.5532~5539 (2002)
  14. gene induction by the interferon regulatory factor family of transcription factors, "Immunity", 2006, 349~360
  15. Liu S, "Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation", Science, 347, pp.aaa2630~ (2015)
  16. 위지민, "Construction and Characterization of an Anti-Hepatitis B Virus preS1 Humanized Antibody that Binds to the Essential Receptor Binding Site", Journal of Microbiology and Biotechnology, 27(7), pp.1336~1344 (2017), 한국미생물·생명공학회[DOI]
  17. Bode JG, "IFN-α antagonistic activity of HCV core protein involves induction of suppressor of cytokine signaling-3", FASEB J, 17, pp.488~490 (2003)
  18. Kang SM, "Modulation of interferon signaling by hepatitis C virus non-structural 5A protein: implication of genotypic difference in interferon treatment", FEBS Lett, 584, pp.4069~4076 (2010)
  19. Lan KH, "HCV NS5A inhibits interferon-alpha signaling through suppression of STAT1 phosphorylation in hepatocyte-derived cell lines", J. Hepatol, 46, pp.759~767 (2007)
  20. Li K, "Immune evasion by hepatitis C virus NS3", 4A proteasemediated cleavage of the Toll-like receptor 3 adaptor protein TRIF, 2005, pp.102, 2992~2997
  21. Li XD, "Hepatitis C virus protease NS3", 4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity, 2005, pp.102, 17717~17722
  22. Lin W, "Hepatitis C virus core protein blocks interferon signaling by interaction with the STAT1 SH2 domain", J. Virol, 80, pp.9226~9235 (2006)
  23. Taylor DR, "Inhibition of the interferon-inducible protein kinase PKR by HCV E2protein", Science, 285, pp.107~110 (1999)
  24. Jilani N, "Hepatitis E virus infection and fulminant hepatic failure during pregnancy", J. Gastroenterol. Hepatol, 22, pp.676~682 (2007)
  25. Navaneethan U, "Hepatitis E and pregnancy: understanding the pathogenesis", Liver Int, 28, pp.1190~1199 (2008)
  26. Krain LJ, "Host immune status and response to hepatitis E virus infection", Clin. Microbiol. Rev, 27, pp.139~165 (2014)
  27. Zhou X, "Disparity of basal and therapeutically activated interferon signalling in constraining hepatitis E virus infection", J. Viral Hepat, 23, pp.294~304 (2016)
  28. Karpe YA, "Deubiquitination activity associated with hepatitis E virus putative papain-like cysteine protease", J. Gen. Virol, 92, pp.2088~2092 (2011)
  29. Nan Y, "Hepatitis E virus inhibits type I interferon induction by ORF1products", J. Virol, 88, pp.11924~11932 (2014)
  30. Oshiumi H, "A distinct role of Riplet-mediated K63-Linked polyubiquitination of the RIG-I repressor domain in human antiviral innate immune responses", PLoS Pathog, 9, pp.e1003533~ (2013)
  31. 최슬기, "Recombinant Adeno-Associated Virus Expressing Truncated IK Cytokine Diminishes the Symptoms of Inflammatory Arthritis", Journal of Microbiology and Biotechnology, 27(10), pp.1892~1895 (2017), 한국미생물·생명공학회
  32. Faysal Bin Hamid, "Characterization of Prototype Foamy Virus Infectivity in Transportin 3 Knockdown Human 293t Cell Line", Journal of Microbiology and Biotechnology, 27(2), pp.380~387 (2017), 한국미생물·생명공학회[DOI]
  33. 김미주, "Development of a One-Step Duplex RT-PCR Method for the Simultaneous Detection of VP3", VP1 and VP1, Journal of Microbiology and Biotechnology, pp.2016, 26(8)[DOI]
  34. 이진무, "A Novel Chemical Compound for Inhibition of SARS Coronavirus Helicase", Journal of Microbiology and Biotechnology, 27(11), pp.2070~2073 (2017), 한국미생물·생명공학회
  35. 이진무, "An Aptamer-Based Electrochemical Sensor That Can Distinguish Influenza Virus Subtype H1 from H5", Journal of Microbiology and Biotechnology, 27(11), pp.2037~2043 (2017), 한국미생물·생명공학회
  36. 임소라, "Alterations in Acetylation of Histone H4 Lysine 8 and Trimethylation of Lysine 20 Associated with Lytic Gene Promoters during Kaposi’s Sarcoma-Associated Herpesvirus Reactivation", Journal of Microbiology and Biotechnology, 27(1), pp.189~196 (2017), 한국미생물·생명공학회[DOI]
  37. Yasmine Samy Elkholy, "Evaluation of a novel commercial quaternary ammonium compound for eradication of Mycobacteria, HCV and HBV in Egypt", The Journal of Microbiology, 54(1), pp.39~43 (2016), 한국미생물학회[DOI]
  38. 정호철, "Exploiting virus-like particles as innovative vaccines against emerging viral infections", The Journal of Microbiology, 55(3), pp.220~230 (2017), 한국미생물학회
  39. 김지현, "Hepatitis C virus infection stimulates transforming growth factor-β1 expression through up-regulating miR-192", The Journal of Microbiology, 54(7), pp.520~526 (2016), 한국미생물학회[DOI]
  40. 신진수, "Comparison of anti-influenza virus activity and pharmacokinetics of oseltamivir free base and oseltamivir phosphate", The Journal of Microbiology, 55(12), pp.979~983 (2017), 한국미생물학회[DOI]

관련 논문AI추천

Hepatitis E Virus Methyltransferase Inhibits Type I Interferon Induction by Targeting RIG-I강상민, 권요셉, 김성준, 노성운, 명진종, 박미경, 최인수, 최종선, 최창순, 한귀남한국미생물·생명공학회 · Journal of Microbiology and Biotechnology2018 · 제28권 제9호Dose-Dependent Inhibition of Melanoma Differentiation-Associated Gene 5-Mediated Activation of Type I Interferon Responses by Methyltransferase of Hepatitis E Virus강상민, 명진종한국미생물·생명공학회 · Journal of Microbiology and Biotechnology2019 · 제29권 제7호Hepatitis E Virus Papain-Like Cysteine Protease Inhibits Type I Interferon Induction by Down-Regulating Melanoma Differentiation-Associated Gene 5김은하, 명진종한국미생물·생명공학회 · Journal of Microbiology and Biotechnology2018 · 제28권 제11호C형 간염 바이러스 NS5B 단백질과 숙주의 p48 단백질의 상호작용에 의한 인터페론 저항성의 유도명희준, 박소연, 이종호한국미생물·생명공학회 · 한국미생물·생명공학회지2008 · 제36권 제4호Dengue Virus 2 NS2B Targets MAVS and IKKε to Evade the Antiviral Innate Immune ResponseChen Jinzhi, Deng Dongqing, Long Qizhou, Mou Lumin, Nie Ying, Wu Jiahong한국미생물·생명공학회 · Journal of Microbiology and Biotechnology2023 · 제33권 제5호Regulation of antiviral innate immune signaling and viral evasion following viral genome sensing이종수, Chathuranga Kiramage, Dodantenna Niranjan, Weerawardhana Asela생화학분자생물학회 · Experimental and Molecular Medicine2021 · 제53권

이 간행물의 다른 논문 (14건)

Properties of Tetragenococcus halophilus Strains Isolated from Myeolchi (anchovy)-jeotgal김정환, 김현진, Zhuang Yao, 김정아, Venkatesh Perumalpp. 313-319파지디스플레이를 이용한 성장인자 안정화 제형 맞춤형 피부 투과 펩타이드의 개발이설훈pp. 326-333Genome Profiling for Health Promoting and Disease Preventing Traits Unraveled Probiotic Potential of Bacillus clausii B106V. Gowdaman, N.G. Kapse, A. S. Engineer, S. Wagh, P. K. Dhakephalkarpp. 334-345Bacteriophages: A New Weapon for the Control of Bacterial Blight Disease in Rice Caused by Xanthomonas oryzaePandurangan Ranjani, Yaram Gowthami, Samuel, S Gnanamanickam, Perumal Palanipp. 346-359지모 뿌리 추출물과 분획물의 항균활성과 항산화 활성 및 세포보호 연구박수남, 이상래, 신혁수, 이윤주, 송바름pp. 360-371
원문 보기