한국 소아 청소년 남아에서 복부 지방 분포 측정의 임상적 의의
Clinical Significance of Abdominal Fat Distribution in Korean Male Children and Adolescents
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Purpose: Visceral adipose tissue may be strongly linked to increased metabolic risks in adults. However, because little is known regarding the effect of visceral adipose tissue in children and adolescents, we performed this study to determine the association between abdominal fat distribution and metabolic risk factors in this population. Methods: One hundred one children and adolescents (78 males and 23 females; mean age, 10.8±2.4 years) were enrolled. The anthropometric data and metabolic risk factors were evaluated. Theabdominal fat distribution was assessed according to the CT measurement. Age-adjusted, partial correlations were performed among the visceral adipose fat area (VFA), subcutaneous adiposefat area (SFA), metabolic risk factors, and anthropometrics. Results: The SFA increased more rapidly than the VFA with advancing years in both genders. In males, the VFA and SFA were positively correlated with anthropometrics. The VFA was correlated with low HDL-cholesterol and the SFA was correlated with diastolic blood pressure (DBP). However, there was no statistical significance between the VFA, SFA, anthropometrics, and other metabolic risk factors. The VFA and SFA were strongly linked to a number of metabolic risk factors, such as other anthropometrics. Conclusion: This study investigated how a low HDL-C was correlated with VFA and how a high DBP was associated with SFA in Korean male children and adolescents. Our results suggest that the correlation between the VFA, SFA, and metabolic risk factors was relatively weak compared to that reported in previous adult studies. (Korean J Pediatr Gastroenterol Nutr 2010; 13: 172∼179)
Abstract
Purpose: Visceral adipose tissue may be strongly linked to increased metabolic risks in adults. However, because little is known regarding the effect of visceral adipose tissue in children and adolescents, we performed this study to determine the association between abdominal fat distribution and metabolic risk factors in this population. Methods: One hundred one children and adolescents (78 males and 23 females; mean age, 10.8±2.4 years) were enrolled. The anthropometric data and metabolic risk factors were evaluated. Theabdominal fat distribution was assessed according to the CT measurement. Age-adjusted, partial correlations were performed among the visceral adipose fat area (VFA), subcutaneous adiposefat area (SFA), metabolic risk factors, and anthropometrics. Results: The SFA increased more rapidly than the VFA with advancing years in both genders. In males, the VFA and SFA were positively correlated with anthropometrics. The VFA was correlated with low HDL-cholesterol and the SFA was correlated with diastolic blood pressure (DBP). However, there was no statistical significance between the VFA, SFA, anthropometrics, and other metabolic risk factors. The VFA and SFA were strongly linked to a number of metabolic risk factors, such as other anthropometrics. Conclusion: This study investigated how a low HDL-C was correlated with VFA and how a high DBP was associated with SFA in Korean male children and adolescents. Our results suggest that the correlation between the VFA, SFA, and metabolic risk factors was relatively weak compared to that reported in previous adult studies. (Korean J Pediatr Gastroenterol Nutr 2010; 13: 172∼179)
참고문헌 (26)
- Ogden CL, "Prevalence of overweight and obesity in the United States, 1999-2004", JAMA, 295, pp.1549~1555 (2006)
- 오경원, "한국 소아청소년의 비만 유병률 추이: 1997년과 2005년 비교", Korean Journal of Pediatrics, 51(9), pp.950~955 (2008), 대한소아과학회
- Sinaiko AR, "Relation of weight and rate of increase in weight during childhood and adolescence to body size, blood pressure, fasting insulin, and lipids in young adults. The Minneapolis Children's Blood Pressure Study", Circulation, 99, pp.1471~1476 (1999)
- Barton M, "Screening for obesity in children and adolescents: US Preventive Services Task Force recommendation statement", Pediatrics, 125, pp.361~367 (2010)
- Lee S, "Waist circumference is an independent predictor of insulin resistance in black and white youths", J Pediatr, 148, pp.188~194 (2006)
- Zimmet P, "The metabolic syndrome in children and adolescents - an IDF consensus report", Pediatr Diabetes, 8, pp.299~306 (2007)
- Park MJ, "Prevalence and trends of metabolic syndrome among Korean adolescents: from the Korean NHANES survey, 1998∼2005", J Pediatr, 155, pp.529~534 (2009)
- Wajchenberg BL, "Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome", Endocr Rev, 21, pp.697~738 (2000)
- Fox CS, "Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study", Circulation, 39(48) (2007)
- Matsushita Y, "Associations of visceral and subcutaneous fat areas with the prevalence of metabolic risk factor clustering in 6292 Japanese individuals: the Hitachi Health Study", Epub ahead of print, ~ (2010), doi:10.2337[DOI]
- 문진수, "2007 한국 소아 청소년 성장도표 : 개발 과정과 전망", Korean Journal of Pediatrics, 51(1), pp.1~25 (2008), 대한소아과학회
- Cole TJ, "Smoothing reference centile curves: the LMS method and penalized likelihood", Stat Med, 11, pp.1305~1319 (1992)
- Matthews DR, "Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man", Diabetologia, 28, pp.412~419 (1985)
- Weiss R, "Obesity and the metabolic syndrome in children and adolescents", N Engl J Med, 350, pp.2362~2374 (2004)
- Bjorntorp P, "Portal adipose tissue as a generator of risk factors for cardiovascular disease and diabetes", Arteriosclerosis, 105, pp.493~496 (1990)
- Fontana L, "Visceral fat adipokine secretion is associated with systemic inflammation in obese humans", Diabetes, 56, pp.1010~1013 (2007)
- Caprio S, "Fat distribution and cardiovascular risk factors in obese adolescent girls: importance of the intraabdominal fat depot", Am J Clin Nutr, 64, pp.12~17 (1996)
- Suliga E, "Visceral adipose tissue in children and adolescents: a review", Nutr Res Rev, 22, pp.137~147 (2009)
- Kim JA, "Association of abdominal fat distribution and cardiometabolic risk factors among obese Korean adolescents", Diabetes Metab, 34, pp.126~130 (2008)
- Kahn SE, "Mechanisms linking obesity to insulin resistance and type 2 diabetes", Nature, 444, pp.840~846 (2006)
- Fox KR, "Assessment of abdominal fat development in young adolescents using magnetic resonance imaging", Int J Obes Relat Metab Disord, 243, pp.1653~1659 (2000)
- 김정아, "한국성인에서 비만관련 질환을 높이는 내장지방량 기준치", 가정의학회지, 27(3), pp.208~214 (2006), 대한가정의학회
- Jackson AS, "Reliability and validity of bioelectrical impedance in determining body composition", J Appl Physiol, 64, pp.529~534 (1988)
- Kullberg J, "Whole-body adipose tissue analysis: comparison of MRI, CT and dual energy X-ray absorptiometry", Br J Radiol, 82, pp.123~130 (2009)
- Stolk RP, "Validity and reproducibility of ultrasonography for the measurement of intra-abdominal adipose tissue", Int J Obes Relat Metab Disord, 25, pp.1346~1351 (2001)
- Blouin K, "Androgens and body fat distribution", J Steroid Biochem Mol Biol, 108, pp.272~280 (2008)