광주, 전남 지역 소아의 A형 간염 항체 보유율에 대한 연구
An Epidemiologic Study on the Seropositive Rate of Hepatitis A Virus in Children of Gwangju and Jeonnam
0
조회
0
다운로드
2
인용
0
참고문헌
키워드
초록
Purpose: Recently, the incidence of acute hepatitis A has increased nationwide and is related to a low rate of IgG anti-HAV production. To establish effective measures for preventing hepatitis A virus infection, an epidemiologic study on the seroprevalence of anti-HAV is needed. Thus, we investigated the seroprevalence of IgG anti-HAV in children living in Gwangju and Jeonnam. Methods: IgG anti-HAV levels were measured in a total of 1,435 patients who visited Chosun University Hospital between January 2009 and December 2009. Results: The overall seropositve rate was 40.8% (586/1,435). The seropositive rates were 41% among children under the age of 1 year, 49.9% for children 1∼5 years old, 51.1% among individuals 5∼10 years old, 12.9% for individuals 10∼15 years old, and 8.2% for subjects over 15 years old. There was no significant difference between genders in any group. The seropositive rates in Gwangju and Jeonnam were 57.3% and 32.9% for children under the age of 1 year, 52.5% and 44.3% for children 1∼5 years old, 60.2% and 33.9% among children 5∼10 years old, 14.1% and 9.7% for children 10∼15 years old, and 10.8% and 4.2% for individuals over 15 years old. Conclusion: The results demonstrated the low rates of IgG anti-HAV, particularly among subjects over 10 years old, which suggests the possibility of increasing clinical HAV infection rates among adults in the near future. We should actively prevent the spread of hepatitis A virus. Vaccination is the most effective means of preventing hepatitis A virus transmission among persons at risk for infection. Hepatitis A vaccination is recommended for children who have low IgG anti-HAV seropositive rates. (Korean J Pediatr Gastroenterol Nutr 2011; 14: 67∼73)
Abstract
Purpose: Recently, the incidence of acute hepatitis A has increased nationwide and is related to a low rate of IgG anti-HAV production. To establish effective measures for preventing hepatitis A virus infection, an epidemiologic study on the seroprevalence of anti-HAV is needed. Thus, we investigated the seroprevalence of IgG anti-HAV in children living in Gwangju and Jeonnam. Methods: IgG anti-HAV levels were measured in a total of 1,435 patients who visited Chosun University Hospital between January 2009 and December 2009. Results: The overall seropositve rate was 40.8% (586/1,435). The seropositive rates were 41% among children under the age of 1 year, 49.9% for children 1∼5 years old, 51.1% among individuals 5∼10 years old, 12.9% for individuals 10∼15 years old, and 8.2% for subjects over 15 years old. There was no significant difference between genders in any group. The seropositive rates in Gwangju and Jeonnam were 57.3% and 32.9% for children under the age of 1 year, 52.5% and 44.3% for children 1∼5 years old, 60.2% and 33.9% among children 5∼10 years old, 14.1% and 9.7% for children 10∼15 years old, and 10.8% and 4.2% for individuals over 15 years old. Conclusion: The results demonstrated the low rates of IgG anti-HAV, particularly among subjects over 10 years old, which suggests the possibility of increasing clinical HAV infection rates among adults in the near future. We should actively prevent the spread of hepatitis A virus. Vaccination is the most effective means of preventing hepatitis A virus transmission among persons at risk for infection. Hepatitis A vaccination is recommended for children who have low IgG anti-HAV seropositive rates. (Korean J Pediatr Gastroenterol Nutr 2011; 14: 67∼73)
참고문헌 (23)
- Cuthbert JA, "Hepatitis A: old and new", Clin Microbiol Rev, 14, pp.38~58 (2011)
- Hong WS, "Seroepidemoiology of type A and type B hepatitis in Seoul Area", Korean J Intern Med, 25, pp.19~26 (1982)
- Choi W, "Patterns of acute hepatitis A and anti-HAV sero-prevalence of Kyungin Province", Korean J Gastroenterol, 34, pp.69~75 (1999)
- Kim NJ, "An outbreak of hepatitis A in Taejeon city", Korean J Gastroenterol, 34, pp.250~212 (1999)
- Glikson M, "Relapsing hepatitis A. Review of 14 cases and literature survey", Medicine, 71, pp.14~23 (1992)
- Advisory Committee on Immunization Practices (ACIP), "Prevention of hepatitis A through active or passive immunization: recommendations of the Advisory Committee on Immunization Practices (ACIP)", MMWR Recomm Rep, 55, pp.1~23 (2006)
- Hadler SC, "Hepatitis A in day care centers. A community-wide assessment", N Engl J Med, 302, pp.1222~1227 (1980)
- 최혜진, "국내에서 2005년에 실시한 연령별 A형 간염 바이러스 항체 보유율", 소아감염, 12(2), pp.186~194 (2005), 한국소아감염병학회
- Feinstone SM, "Hepatitis A:detection by immune electron microscopy of a viruslike antigen associated with acute illness", Science, 182, pp.1026~1028 (1973)
- Moon KR, "Hepatitis A", Korean J Pediatr Gastroenterol Nutr, 11, pp.44~49 (2008)
- 윤희상, "한국 소아 A형 간염 현황", Korean Journal of Pediatrics, 51(7), pp.690~695 (2008), 대한소아과학회
- Nelson KE, "Global changes in the epidemiology of hepatitisA virus infections", Clin Infect Dis, 42, pp.1151~1152 (2006)
- Centers for Disease Control and Prevention, "Prevention of hepatitis A through active or passive immunization: Recommendation of the Advisory Committee on Immunization Practices (ACIP)", MMWR Morb Mortal Wkly Rep, 48(12), pp.1~37 (1999)
- Kim CY, "Seroepidemiology of type A and type B hepatitis in Seoul area", Korean J Intern Med, 25, pp.19~27 (1982)
- Lee JI, "Epidemiologic study of antibody to hepatitis A antigen in Choong Chung area", Korean J Gastroenterol, 14, pp.87~91 (1982)
- Kim TW, "Antibody of hepatitis A antigen in children and adolescents in Korea", J Korean Pediatr Soc, 25, pp.36~40 (1982)
- Lee KY, "Seroepidemiology of hepatitis A in Taejon, Korea 1996", J Korean Pediatr Soc, 41, pp.53~61 (1998)
- Park CH, "Changes in teh age-specific prevalence of hepatitis A virus antibodies: a 10 year cohort study in Jinju, South Korea", Clin Infect Dis, 15, pp.1148~1150 (2006)
- Kim SY, "Concordance of Seropositivity between Helicobacter pylori and Hepatitis A virus IgG in children of Gwangju and Chonnam Area", Korean J Pediatr Gastroenterol Nutr, 4, pp.191~198 (2011)
- Kim H, "Epidemiologic changes and clinical features of hepatitis A in children; living in Kyung-gi province, since 1988 to 1998", Korean J Pediatr Infect Dis, 5, pp.230~236 (1998)
- Duval B, "Nationwide Canadian study of hepatitis A antibody prevalence among children eight to thirteen years old", J Pediatr Infect Dis, 24, pp.514~519 (2005)
- 송영봉, "한국인 건강검진자에서 연령 특이적 A형간염바이러스 항체 혈청 양성률대한간학회지 제 13 권 제 1 호 2007 ; 27-33", Clinical and Molecular Hepatology, 13(1), pp.27~33 (2007), 대한간학회
- CDC, "Prevention of hepatitis A through active or passive immunization. Recommendations of the Advisory Committee on Immunization Practices (ACIP)", MMWR Morb Mortal Wkly Rep, 55, pp.1~23 (2006)