굴피나무 추출물의 항균 활성 및 추출물을 함유한 크림의 안정성 분석
Antibacterial Activity of Platycarya strobilacea Extract and Stability of the Extract-containing Cream
2
조회
0
다운로드
13
인용
0
참고문헌
키워드
초록
The extract of Platycarya strobilacea is known to possess a wide range of pharmacological activities including anti-inflammatory, anti-fungal, and anti-cancer properties. We have reported that the ethyl acetate fraction of Platycarya strobilacea (PS-ET fraction) has high potential as an antioxidant agent (J. Soc. Cosmet. Scientists Korea 34(4) 275, 2008). In this study, antibacterial activity of the fraction and stability of the cream containing 0.2% PS-ET fraction were investigated for the application to cosmetics. Antibacterial activity of PS-ET fraction against various skin pathogenic bacteria (Propionibacterium acnes, Staphylococcus aureus, and Pityrosporum ovale) was measured by minimum inhibitory concentration (MIC). MIC values of PS-ET fraction on P. acnes, S. aureus, and P. ovale were 0.13%, 0.06% and 0.25%, respectively. The results showed that the antibacterial activity of the fraction was the highest in the S. aureus. For the stability evaluation, pH and viscosity of the cream containing 0.2% PS-ET fraction were measured. The results showed that pH changes of the cream containing PS-ET fraction was lower than the control cream without PS-ET fraction. And the PS-ET fraction could repress the decrease of viscosity of the cream against sunlight treatment. These results suggest that the fraction of Platycarya strobilacea has high potential as bactericide against the skin pathogenic bacteria and could be added to improve the stability of cosmetic products.
Abstract
The extract of Platycarya strobilacea is known to possess a wide range of pharmacological activities including anti-inflammatory, anti-fungal, and anti-cancer properties. We have reported that the ethyl acetate fraction of Platycarya strobilacea (PS-ET fraction) has high potential as an antioxidant agent (J. Soc. Cosmet. Scientists Korea 34(4) 275, 2008). In this study, antibacterial activity of the fraction and stability of the cream containing 0.2% PS-ET fraction were investigated for the application to cosmetics. Antibacterial activity of PS-ET fraction against various skin pathogenic bacteria (Propionibacterium acnes, Staphylococcus aureus, and Pityrosporum ovale) was measured by minimum inhibitory concentration (MIC). MIC values of PS-ET fraction on P. acnes, S. aureus, and P. ovale were 0.13%, 0.06% and 0.25%, respectively. The results showed that the antibacterial activity of the fraction was the highest in the S. aureus. For the stability evaluation, pH and viscosity of the cream containing 0.2% PS-ET fraction were measured. The results showed that pH changes of the cream containing PS-ET fraction was lower than the control cream without PS-ET fraction. And the PS-ET fraction could repress the decrease of viscosity of the cream against sunlight treatment. These results suggest that the fraction of Platycarya strobilacea has high potential as bactericide against the skin pathogenic bacteria and could be added to improve the stability of cosmetic products.
참고문헌 (17)
- A.O.A.C, "Official methods of analysis. 13th ed., Association of official analytical chemists" (1980), Washington, D.C.
- Dinesh Babu, "Involvement of NF-κB in the Inhibitory Actions of Platycarya strobilacea on the TNF-α- Induced Monocyte Adhesion to Colon Epithelial Cells and Chemokine Expression", Archives of Pharmacal Research, 31(6), pp.727~735 (2008), 대한약학회
- Choi, Y. H, "Isolation of an Antifungal compound from aerial parts of Platycarya strobilacea", J. Korea Soc. Agric. Chem. Biotechnol, 46(3), pp.268~270 (2003)
- 동 석, "용매별 정향 추출물의 항산화효과", 한국식품영양과학회지, 33(4), pp.609~613 (2004), 한국식품영양과학회
- 박수남, "나문재 추출물 함유 크림의 안정성 평가에 관한 연구", 대한화장품학회지, 33(4), pp.231~238 (2007), 대한화장품학회
- Kim, K. H, "A composition comprising the fruit extract of Platycarya strobilacea having anti-aging activity", ~ (2008)
- Kim, M. K, "Screening of Acyl-CoA: Cholesterol acyltransferase(ACAT) inhibitors from natural sources", Kor. J. Pharmacogn, 30(4), pp.384~396 (1999)
- 박수남, "밤나무 잎 추출물의 항노화 활성 및 화장품에의 응용(Ⅰ)", 대한화장품학회지, 34(4), pp.259~268 (2008), 대한화장품학회
- 이성현, "구절초(Chrysanthemum zawadskii)로부터 비듬균에 대한항균물질의 생산 및 특성", 한국미생물·생명공학회지, 35(3), pp.220~225 (2007), 한국미생물·생명공학회
- 이학주, "굴피나무(Platycarya strobilacea) 수피의 Flavonol glycosides", 한국임학회지, 96(4), pp.408~413 (2007), 한국임학회
- Lee, J. H, "Flavonoids from the stem bark of Platycarya strobilacea", Kor. J. Pharmacogn, 29(4), pp.353~356 (1998)
- 박수남, "O2으로 유도된 사람 적혈구의 광용혈에 있어서 대두의 아이소플라본인 제니스테인의 보호작용", 한국식품과학회지, 35(3), pp.510~518 (2003), 한국식품과학회
- Park, S. N, "Antioxidative properties of baicalein, component from Scutellaria baicalensis Georgi and its application to cosmetics(I)", J. Korean Ind. Eng. Chem., 14(5), pp.657~665 (2003)
- Park, J. H, "Medical plants of Korea", pp.313~ (2004), Shinil books
- 박수남, "나문재 추출물의 성분 분석", 대한화장품학회지, 34(3), pp.157~165 (2008), 대한화장품학회
- 박수남, "굴피나무 추출물의 항산화, 항노화 효과 및 인체 시험", 대한화장품학회지, 34(4), pp.275~286 (2008), 대한화장품학회
- Yook, C. S, "Coloured medical plants of Korea", pp.117~ (1990), Academybook