Effect of Synbiotic on the Treatment of Jaundice in Full Term Neonates: A Randomized Clinical Trial
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Purpose: Jaundice accounts for most hospital admissions in the neonatal period. Nowadays, in addition to phototherapy, other auxiliary methods are used to reduce jaundice and the length of hospitalization. This study aimed to investigate the effect of probiotics on the treatment of hyper-bilirubinemia in full-term neonates. Methods: In this randomized clinical trial, 83 full-term neonates, who were admitted to the hospital to receive phototherapy in the first 6 months of 2015, were randomly divided into two groups: synbiotic (SG, n=40) and control (CG, n=43). Both groups received phototherapy but the SG also received 5 drops/day of synbiotics. Serum bilirubin, urine, stool, feeding frequency, and weight were measured daily until hospital discharge. A p-value<0.05 was considered statistically significant. Results: The mean total serum bilirubin in the SG was lower than that in the CG (9.38±2.37 and 11.17±2.60 mg/dL, respectively). The urine and stool frequency in the SG was significantly higher than that in the CG (p<0.05). The duration of hospitalization in the SG was shorter than that in the CG. Conclusion: Use of synbiotics as an adjuvant therapy had a significant treatment effect on jaundice in full-term neonates. Further studies including larger samples with long follow-up periods are essential to confirm the benefits of routine use of synbiotics in neonatal patients with jaundice.
Abstract
Purpose: Jaundice accounts for most hospital admissions in the neonatal period. Nowadays, in addition to phototherapy, other auxiliary methods are used to reduce jaundice and the length of hospitalization. This study aimed to investigate the effect of probiotics on the treatment of hyper-bilirubinemia in full-term neonates. Methods: In this randomized clinical trial, 83 full-term neonates, who were admitted to the hospital to receive phototherapy in the first 6 months of 2015, were randomly divided into two groups: synbiotic (SG, n=40) and control (CG, n=43). Both groups received phototherapy but the SG also received 5 drops/day of synbiotics. Serum bilirubin, urine, stool, feeding frequency, and weight were measured daily until hospital discharge. A p-value<0.05 was considered statistically significant. Results: The mean total serum bilirubin in the SG was lower than that in the CG (9.38±2.37 and 11.17±2.60 mg/dL, respectively). The urine and stool frequency in the SG was significantly higher than that in the CG (p<0.05). The duration of hospitalization in the SG was shorter than that in the CG. Conclusion: Use of synbiotics as an adjuvant therapy had a significant treatment effect on jaundice in full-term neonates. Further studies including larger samples with long follow-up periods are essential to confirm the benefits of routine use of synbiotics in neonatal patients with jaundice.
참고문헌 (26)
- Alex M, "Toward understanding the connections between infant jaundice and infant feeding", J Pediatr Nur, 23, pp.429~438 (2008)
- Martin RJ, "Fanaroff and Martin's neonatal perinatal medicine diseases of the fetus and infant" (2006), Mosby
- Cohen SM, "Jaundice in the full-term newborn", Pediatr Nurs, 32, pp.202~208 (2006)
- American Academy of Pediatrics Subcommittee on Hyperbilirubinemia, "Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation", Pediatrics, 114, pp.297~316 (2004)
- Mahe E, "Neonatal blue-light phototherapy does not increase nevus count in 9-year-old children", Pediatrics, 123, pp.e896~900 (2009)
- McDonagh AF, "Bilirubin, copper-porphyrins, and the bronze-baby syndrome", J Pediatr, 158, pp.160~164 (2011)
- Bhutani VK, "The clinical syndrome of bilirubin-induced neurologic dysfunction", Semin Fetal Neonatal Med, 20, pp.6~13 (2015)
- McDonagh AF, "Bilirubin unbound : deja vu all over again?", Pediatrics, 117, pp.523~525 (2006)
- Nag N, "Role of bilirubin as antioxidant in neonatal jaundice and effect of ethanolic extract of sweet lime peel on experimentally induced jaundice in rat", Indian J Biochem Biophys, 46, pp.73~78 (2009)
- Stanton C, "Market potential for probiotics", Am J Clin Nutr, 73(2 Suppl), pp.476S~483S (2001)
- Cummings JH, "Intestinal bacteria and ulcerative colitis", Curr Issues Intest Microbiol, 4, pp.9~20 (2003)
- Salminen S, "Functional food science and gastrointestinal physiology and function", Br J Nutr, 80(Suppl 1), pp.S147~171 (1998)
- Sur D, "Role of probiotic in preventing acute diarrhoea in children : a community-based, randomized, double-blind placebo-controlled field trial in an urban slum", Epidemiol Infect, 139, pp.919~926 (2011)
- Prescott SL, "Probiotics for the prevention or treatment of allergic diseases", J Allergy Clin Immunol, 120, pp.255~262 (2007)
- Hoyos AB, "Reduced incidence of necrotizing enterocolitis associated with enteral administration of Lactobacillus acidophilus and Bifidobacterium infantis to neonates in an intensive care unit", Int J Infect Dis, 3, pp.197~202 (1999)
- Maruo Y, "Prolonged unconjugated hyperbilirubinemia associated with breast milk and mutations of the bilirubin uridine diphosphate-glucuronosyltransferase gene", Pediatrics, 106, pp.E59~ (2000)
- Porter ML, "Hyperbilirubinemia in the term newborn", Am Fam Physician, 65, pp.599~606 (2002)
- Armanian AM, "Prebiotics for the management of hyperbilirubinemia in preterm neonates", J Matern Fetal Neonatal Med, 29, pp.3009~3013 (2016)
- Chen Z, "Probiotics supplementation therapy for pathological neonatal jaundice : a systematic review and meta-analysis", Front Pharmacol, 8, pp.432~ (2017)
- Deshmukh J, "Probiotics for the management of neonatal hyperbilirubinemia : a systematic review of randomized controlled trials", J Matern Fetal Neonatal Med, 32, pp.154~163 (2019)
- Torkaman M, "Platelet count and neonatal sepsis : a high prevalence of Enterobacter spp", Singapore Med J, 50, pp.482~485 (2009)
- Goldin BR, "The relationship between diet and rat fecal bacterial enzymes implicated in colon cancer", J Natl Cancer Inst, 57, pp.371~375 (1976)
- Goldin BR, "Effect of Lactobacillus acidophilus dietary supplements on 1, 2-dimethylhydrazine dihydrochloride-induced intestinal cancer in rats", J Natl Cancer Inst, 64, pp.263~265 (1980)
- Osborn LM, "Jaundice in the full-term neonate", Pediatrics, 73, pp.520~525 (1984)
- Shokoufeh Ahmadipour, "Treating Viral Diarrhea in Children by Probiotic and Zinc Supplements", Pediatric Gastroenterology, Hepatology & Nutrition, 22(2), pp.162~170 (2019), 대한소아소화기영양학회[DOI]
- Preer GL, "Understanding and managing breast milk jaundice", Arch Dis Child Fetal Neonatal Ed, 96, pp.F461~466 (2011)