신생아 황달의 예방적 치료에 대한 연구동향
A Review of the Treatment to Prevent Neonatal Jaundice - Based on Traditional Chinese Medicine
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Introduction Jaundice is one of the most common conditions found in neonatal period. Phototherapy is one of the main treatments for neonatal jaundice. However, several adverse effects of the phototherapy have been reported, including DNA damage recently. Therefore, a variety of treatments have been conducted to shorten the duration of phototherapy. Meanwhile, it has been hardly tried to prevent neonatal jaundice, but diverse approaches have been tried in traditional Chinese medicine (TCM) for many years. Therefore, this study aims to analyze the studies for the treatments to prevent neonatal jaundice based on TCM. Materials and Methods Various literatures have been searched via CNKI, and PubMed using the terms “neonatal jaundice” (新生儿黄疸, 胎黃, 胎疸) in category of 'Traditional Chinese Medicine', 'Traditional Chinese Medicinal Herbs' and 'Combination of Traditional Chinese Medicine With Western Medicine'. The search range included randomized controlled trials (RCTs), controlled clinical trials (CCTs), case reports, reviews and animal experiments published from 2013 to 2015. Results A total of 104 studies were found. 93 articles were excluded by reviewing the titles and abstracts. Out of the remaining 11 studies, 9 articles were RCTs, 2 articles were CCTs. The treatment used in neonatal babies in the studies were, using herbal remedies (meditation 5, bath 3 and retention enema 1) and the acupressure. All treatments were initiated within the first 24-48 hours after their birth. Then, there was a study that the subjects taken the herbal medicine were women during pregnancy. The outcome assessments used were the serum total bilirubin (TB), transcutaneous bilirubin measurement (TCB), the incidence of the hyperbilirubinemia, the duration time of the jaundice. Especially, TB, TCB and the incidence of the hyperbilirubinemia have decreased significantly more than that of the control group in the most of the results. No severe adverse events were reported in all articles reviewed. Conclusions Conventional treatment such as, herbal medicine in TCM, seems to be the effective way to prevent neonatal jaundice or hyperbilirubinemia. Therefore, the conventional treatment may be favorable choice for preventive treatment for neonatal jaundice.
Abstract
Introduction Jaundice is one of the most common conditions found in neonatal period. Phototherapy is one of the main treatments for neonatal jaundice. However, several adverse effects of the phototherapy have been reported, including DNA damage recently. Therefore, a variety of treatments have been conducted to shorten the duration of phototherapy. Meanwhile, it has been hardly tried to prevent neonatal jaundice, but diverse approaches have been tried in traditional Chinese medicine (TCM) for many years. Therefore, this study aims to analyze the studies for the treatments to prevent neonatal jaundice based on TCM. Materials and Methods Various literatures have been searched via CNKI, and PubMed using the terms “neonatal jaundice” (新生儿黄疸, 胎黃, 胎疸) in category of 'Traditional Chinese Medicine', 'Traditional Chinese Medicinal Herbs' and 'Combination of Traditional Chinese Medicine With Western Medicine'. The search range included randomized controlled trials (RCTs), controlled clinical trials (CCTs), case reports, reviews and animal experiments published from 2013 to 2015. Results A total of 104 studies were found. 93 articles were excluded by reviewing the titles and abstracts. Out of the remaining 11 studies, 9 articles were RCTs, 2 articles were CCTs. The treatment used in neonatal babies in the studies were, using herbal remedies (meditation 5, bath 3 and retention enema 1) and the acupressure. All treatments were initiated within the first 24-48 hours after their birth. Then, there was a study that the subjects taken the herbal medicine were women during pregnancy. The outcome assessments used were the serum total bilirubin (TB), transcutaneous bilirubin measurement (TCB), the incidence of the hyperbilirubinemia, the duration time of the jaundice. Especially, TB, TCB and the incidence of the hyperbilirubinemia have decreased significantly more than that of the control group in the most of the results. No severe adverse events were reported in all articles reviewed. Conclusions Conventional treatment such as, herbal medicine in TCM, seems to be the effective way to prevent neonatal jaundice or hyperbilirubinemia. Therefore, the conventional treatment may be favorable choice for preventive treatment for neonatal jaundice.
참고문헌 (33)
- Kwon JB, "Effect of oral administration of dioctahedral smectiteand cholestyramine with phototherapy in the treatment of neonatal hyperbilirubinemia", J Korean Soc Neonatal, 7, pp.39~44 (2000)
- 이상락, "신생아황달", Korean Journal of Pediatrics, 49(1), pp.6~13 (2006), 대한소아과학회
- 이용권, "신생아 황달에서 광선치료 동안에 경피적 빌리루빈 측정기의 유용성", Korean Journal of Pediatrics, 49(12), pp.1296~1300 (2006), 대한소아과학회
- Stoll BJ, "Nelson Textbook of Pediatrics", pp.592~599 (2004), vWB Saunders Co
- American Academy of Pediatrics Subcommittee on Hyperbilirubinemia, "Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation", Pediatr, 114, pp.297~316 (2004)
- Christensen T, "Single-strand breaks in the DNA of human cells exposed to visible light from phototherapy lamps in the presence and absence of bilirubin", J Photochem Phtobiol B, 7, pp.337~346 (1990)
- Kim KB, "Hanbangsoacheongsonyeonuihak", pp.239~ (2010), Eui Sung Dang Publishing Co
- He LC, "The effect observation of Yinchen Chaihutang to prevent neonatal hyperbilirubinemia", Forum Tradit Chin Med, 29(2), pp.35~ (2014)
- Pang PG, "The effect observation of traditional Chinese medicine in prevention neonatal hyperbilirubinemia", J New Chin Med, 46(5), pp.138~140 (2014)
- Zhu CY, "The effect observation of rhubarb in preventing icterus neonatorum", Zhejiang Med Educ, 12(11), pp.62~63 (2013)
- Wang B, "The effect observation of Yinzhihuang Koufuye to prevent neonatal hyperbilirubinemia", C J GMCM, 27(11), pp.2218~2219 (2012)
- Tong XF, "The effect observation of Yinzhihuang Koufuye to prevent neonatal hyperbilirubinemia", Strait Pharm J, 25(6), pp.184~185 (2013)
- Gong HY, "The effect observation of Yinchen Wuling Tangjiang to prevent neonatal hyperbilirubinemia", Chin Community Doctor, 26, pp.179~180 (2016)
- 정민정, "한방산후조리원 산모를 대상으로 실시한 하태독법의 인식 및 의향 조사", 대한한방소아과학회지, 28(4), pp.157~165 (2014), 대한한방소아과학회
- Park MS, "Significance of clinical pharmacology in pediatrics", Pediatr, 40(11), pp.1495~1500 (1997)
- Wu HC, "The effect observation of a medicated bath using Tuihuangwaixiye to prevent neonatal hyperbilirubinemia", China Mod Med, 19(15), pp.92~93 (2012)
- Liu LP, "The effect observation of a medicated bath using Tuihuangxunxifang to prevent neonatal hyperbilirubinemia", TCM Res, 27(4), pp.17~18 (2014)
- Zhou WD, "The effect observation of Yinzhihuangfnagji to prevent neonatal hyperbilirubinemia", Chin Med Mod Distance Educ China, 11(1), pp.16~17 (2013)
- "Information on proper use of medicines for children (for professionals)" (2010)[URL]
- Xie HC, "The effect observation of retention enema using Yinzhihuang Koufuye to prevent neonatal hyperbilirubinemia", Jilin Med J, 33(17), pp.3670~3671 (2012)
- 이명종, "해독요법 중 관장요법에 대한 고찰", 동의신경정신과학회지, 15(2), pp.23~36 (2004), 대한한방신경정신과학회
- 송은영, "보류관장의 표준화된 방법을 위한 고찰을 통한 제언; 실험연구방법에 대하여", 대한한의학회지, 35(1), pp.1~9 (2014), 대한한의학회
- Korean Medical Pharmacology Text publication committee, "Korean Medical Pharmacology", pp.627~574 (2010), Shinil Books
- Kitagawa I, "Capillartemisin A and B, two new choleretic principles from Artemisia Capillaris herba", Chem Pharm Bull, 31, pp.352~355 (1983)
- Sheng L, "Mechanism of hypolipidemic effect of crocin in rats: crocin inhibits pancreatic lipase", Eur J Pharmacol, 14(495), pp.201~208 (2004)
- Lee IA, "Antihyperlipidemic effect of crocin isolated from the fructus of Gardenia Jasminoides and its metabolite Crocetin", Biol Pharm Bull, 28, pp.2106~2110 (2005)
- Tsai JC, "Effect of ethanol extracts of three Chinese medicinal plants with laxative properties on ion transport of the rat intestinal epithelia", Biol Pharm Bull, 27, pp.162~165 (2004)
- Ziao YL, "Investigations of free anthraquinones from rhubarb against alpha-naphthylisothiocyanate-induced cholestatic liver injury in rats", Basic Clin Pharmacol Toxicol, 104, pp.463~469 (2009)
- Yatsunenko T, "Human gut microbiome viewed across age and geography", Nat, 486, pp.222~227 (2012)
- Zhao HM, "A clinical research of meridian conditioning to prevent neonatal hyperbilirubinemia", pp.2012
- An HS, "Textbook of pediatrics", pp.320~321 (2010), MIRAEN Co
- Gourley GR, "The effect of diet on feces and jaundice during the first 3 weeks of life", Gastroenterol, 103(2), pp.660~667 (1992)
- 정민정, "소아 전문 한의사를 대상으로 실시한 하태독법의 인식 및 사용실태 조사", 대한한방소아과학회지, 28(2), pp.88~102 (2014), 대한한방소아과학회