잔가시 모자반 에탄올 추출물의 항아토피 효과
Anti-atopic Activity of Sargassum micracanthum Ethanol Extracts
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초록
Atopic dermatitis (AD) is a common chronic inflammatory disease preceding the development of allergic disorders. The aim ofthis study was to evaluate the effect of Sargassum micracanthum ethanol extract (SMEE) on AD. AD was induced by spreading2,4-dinitrochlorobenzen (DNCB) on the back sides of BALB/c mice. The efficacy of SMEE was tested by observing the skinclinical severity score, proliferations of Raw 264.7 cells and the secretion of cytokines and IgE. The secretion of IL-4, and IgEwas significantly decreased by SMEE in a dose dependent manner, while IFN-γ was increased. In addition, SMEE alleviatedthe AD symptoms better when compared to the positive controls. In conclusion, these results suggest that SMEE has an inhibitoryeffect on AD, and may serve as a useful biomaterial for the development of cosmeceuticals.
Abstract
Atopic dermatitis (AD) is a common chronic inflammatory disease preceding the development of allergic disorders. The aim ofthis study was to evaluate the effect of Sargassum micracanthum ethanol extract (SMEE) on AD. AD was induced by spreading2,4-dinitrochlorobenzen (DNCB) on the back sides of BALB/c mice. The efficacy of SMEE was tested by observing the skinclinical severity score, proliferations of Raw 264.7 cells and the secretion of cytokines and IgE. The secretion of IL-4, and IgEwas significantly decreased by SMEE in a dose dependent manner, while IFN-γ was increased. In addition, SMEE alleviatedthe AD symptoms better when compared to the positive controls. In conclusion, these results suggest that SMEE has an inhibitoryeffect on AD, and may serve as a useful biomaterial for the development of cosmeceuticals.
참고문헌 (35)
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