소아 양성 일과성 고인산분해효소혈증의임상양상 및 자연경과에 대한 고찰
Clinical Features and Natural Course of Benign Transient Hyperphosphatasemia in Children
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목 적: 한국인 소아에서 양성 일과성 고인산분해효소혈증(Benign transient hyperphosphatasemia, BTH)의 임상적 특징 및 자연 경과를 살펴보고자 하였다.방 법: 2006년 6월부터 2007년 7월까지 분당서울대학교병원 소아과를 내원한 환아 중 Kraut 등의 진단기준에 따라 BTH로 진단된 17명의 의무기록과 검사결과를 후향적으로 분석하였다.결 과: 총 17명의 환아 중 남아가 6명, 여아가 11명이었으며, 연령은 평균 26.9 13.8개월(범위: 9 49개월)이었다. 동반된 질환으로는 감염성 질환이 52.9%로 가장 많았고, 계절적으로 9월에서 12월 사이에 더 높은 발생률을 보였다. 첫 내원 시 측정한 혈청 ALP는 평균 2500.2 1165.1 U/L이었고, 모든 환아에서 7주 내에 혈청 ALP가 정상 또는 정상 상한치의 두 배 이내로 감소하였다. ALP isoenzyme 검사를 시행한 7명의 환아 중 3명에서 간 분획과 골 분획의 증가가 있었고, 4명은 골 분획의 증가만을 보였다.
Abstract
Purpose: This study was conducted to analyze the clinical manifestation and natural course of benign transient hyperphosphatasemia (BTH) in children. Methods: A total of 17 children diagnosed with BTH between June 2006 and July 2007, were included in this study. Clinical records and laboratory tests were analyzed retrospectively for all children. Results: The mean age of the patients was 26.9±13.8 months (range: 9 to 49 months). Nine of the 17 BTH cases (52.9%) occurred in patients that had previously suffered from infectious diseases. While the patients were suffering from BTH, the mean serum level of alkaline phosphatase (ALP) was 2,500.2± 1,165.1 U/L, however, these elevated serum ALP levels normalized within 7 weeks of recovery in all cases. In addition, a seasonal peak in the onset of BTH was observed from September to December. Further, the measurement of ALP isoenzymes in 7 of the patients with BTH, revealed a marked elevation of bone fraction. Conclusion: It is important for pediatricians to understand the clinical manifestation and benign course of BTH to avoid unnecessary diagnostic evaluation in children showing a transient increase in ALP activities.
참고문헌 (28)
- Wolf PL, "The significance of transient hyperphosphatasemia of infancy and childhood to the clinician and clinical pathologist", 119, pp.774~775 (1995)
- Kraut JR, "Isoenzyme studies in transient hyperphosphatasemia of infancy Ten new cases and a review of the literature", pp.736~40
- Eboriadou M, "Acute laryngotracheobronchitis and associated transient hyperphosphatasemia: a new case of transient hyperphosphatasemia in early childhood", 42, pp.149~150 (2006)
- Suzuki M, "Viral infection of infants and children with benign transient hyperphosphatasemia", 33, pp.215~218 (2002)
- Goto M, "Is respiratory syncytial virus one of the causative agents for transient hyperphosphatasemia?", 50, pp.1146~1149 (2002)
- Stein P, "Transient hyperphosphatasemia of infancy and early childhood clinical and biochemical features of 21 cases and literature review", pp.313~8
- Behulova D, "Transient hyperphosphatasemia of infancy and childhood: study of 194 cases", 46, pp.1868~1869 (2000)
- Arikan C, "Transient hyperphosphatasemia after pediatric liver transplantation", 48, pp.390~392 (2006)
- Ranchin B, "Transient hyperphosphatasemia after organ transplantation in children", 6, pp.308~312 (2002)
- Crofton PM, "What is the cause of benign transient hyperphosphatasemia? A study of 35 cases", 34, pp.335~340 (1988)
- Tolaymat N, "Benign transient hyperphosphatasemia of infancy and childhood", 93, pp.1162~1164 (2000)
- Choi MH LS, "A study of transient hyperphosphatasemia of infancy and childhood", 16, pp.888~896 (1996)
- Oh JG, "6 cases of transient hyperphosphatasemia of infancy and early childhood", 43, pp.105~110 (2000)
- Okazaki T, "Recognition of benign transient hyperphosphatasemia", 96, pp.108~109 (2003)
- Wolf PL, "The significance of transient hyperphosphatasemia of infancy and childhood to the clinician and clinical pathologist", 119, pp.774~775 (1995)
- Kraut JR, "Kaplan MM. Isoenzyme studies in transient hyperphosphatasemia of infancy. Ten new cases and a review of the literature. Am J Dis Child 1985", pp.736~40
- Eboriadou M, "Acute laryngotracheobronchitis and associated transient hyperphosphatasemia: a new case of transient hyperphosphatasemia in early childhood", 42, pp.149~150 (2006)
- Suzuki M, "Viral infection of infants and children with benign transient hyperphosphatasemia", 33, pp.215~218 (2002)
- Goto M, "Is respiratory syncytial virus one of the causative agents for transient hyperphosphatasemia?", 50, pp.1146~1149 (2002)
- Stein P, "Hjelm M. Transient hyperphosphatasemia of infancy and early childhood clinical and biochemical features of 21 cases and literature review. Clin Chem 1987", pp.313~8
- Behulova D, "Transient hyperphosphatasemia of infancy and childhood: study of 194 cases", 46, pp.1868~1869 (2000)
- Arikan C, "Transient hyperphosphatasemia after pediatric liver transplantation", 48, pp.390~392 (2006)
- Ranchin B, "Transient hyperphosphatasemia after organ transplantation in children", 6, pp.308~312 (2002)
- "Crofton PM. What is the cause of benign transient hyperphosphatasemia A study of 35 cases. Clin Chem 1988", pp.335~40
- Tolaymat N, "Benign transient hyperphosphatasemia of infancy and childhood", 93, pp.1162~1164 (2000)
- Choi MH LS, "A study of transient hyperphosphatasemia of infancy and childhood", 16, pp.888~896 (1996)
- Oh JG, "6 cases of transient hyperphosphatasemia of infancy and early childhood", 43, pp.105~110 (2000)
- Okazaki T, "Recognition of benign transient hyperphosphatasemia", 96, pp.108~109 (2003)