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식품 단백질 유발성 장염 증후군:임상적 접근과 병태생리의 최신 지견

Current Status of Pediatric Liver Transplantation

황진복
대한소아소화기영양학회 (The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition)|2007.09|Pediatric Gastroenterology, Hepatology & Nutrition|제10권 제2호|pp. 117-128

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참고문헌

주제분류소아과학

초록

Abstract

Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE mediated hypersensitivity disorder, which is associated with mainly gastrointestinal symptoms and has a delayed onset. The vomiting and/or diarrheal symptoms of FPIES typically begin in the first month of life in association with a failure to thrive, metabolic acidosis, and shock. Therefore, the differential diagnosis of FPIES and neonatal or infantile sepsis-like illnesses or gastroenteritis is difficult. The early recognition of indexes of suspicion for FPIES may help in the diagnosis and treatment of this disorder. The diagnosis of FPIES is generally made through clinical practice and food-specific IgE test findings are typically negative in this condition. Therefore, oral cow's milk challenge (OCC) remains the valid diagnostic standard for FPIES. An investigation of positive OCC outcomes helps to find out a diagnostic algorithm of criteria of a positive challenge in FPIES. Moreover, it has not been clearly determined in infantile FPIES when 1st follow up-oral food challenge (FU-OFC) should be performed, with what kind of food protein (e.g., cow's milk, soy), and how much protein should be administered. Hence, to prevent the risk of inappropriate FU-OFC or accidental exposure and achieve appropriate dietary management, it is necessary to identify tolerance rates to major foods under the careful follow up of infantile FPIES patients. On the other hand, small intestinal enteropathy with villous atrophy is observed in FPIES and this enteropathy seems to be in part induced by both of epithelial apoptosis and intercellular junctional complex breakdown. The purpose of this report is to introduce an update on diagnostic and therapeutic approaches in FPIES and suggest the possible histopathological evidences in this disorder. (Korean J Pediatr Gastroenterol Nutr 2007; 10: 117∼128)

참고문헌 (55)

  1. Sampson HA, "Summary and recommendations: classification of gastrointestinal manifestations due to immunologic reactions to foods in infants and young children", 30, pp.87S~94S (2000)
  2. Sicherer SH, "Clinical features of food protein-induced enterocolitis syndrome", 133, pp.214~219 (1998)
  3. Powell GK, "Milk- and soy-induced enterocolitis of infancy", 93, pp.553~60 (1978)
  4. Powell GK, "Food protein-induced enterocolitis of infancy:differential diagnosis and management", 12, pp.28~37 (1986)
  5. Burks AW, "Prospective oral food challenge study of two soybean protein isolates in patients with possible milk or soy protein enterocolitis", 5, pp.40~5 (1994)
  6. Powell GK, "Enterocolitis in low-birth-weight infants associated with milk and soy protein intolerance", 88, pp.840~4 (1976)
  7. Murray KF, "Dietary protein intolerance in infants with transient methemoglobinemia and diarrhea", 122, pp.90~2 (1993)
  8. McDonald PJ, "Food protein-induced enterocolitis:altered antibody response to ingested antigen", 18, pp.751~5 (1984)
  9. Chung HL, "Expression of transforming growth factor β1, transforming growth factor type I and II receptors, and TNF-α in the mucosa of the small intestine in infants with food protein-induced enterocolitis syndrome", 109, pp.150~154 (2002)
  10. Sicherer SH, "Food protein-induced enterocolitis syndrome: case presentations and management lessons", 115, pp.149~156 (2005)
  11. Fogg MI, "Atopy patch test for the diagnosis of food protein- induced enterocolitis", 17, pp.351~355 (2006)
  12. 황진복, "새로운 분류법에 따른 소아 위장관 우유 알레르기 질환에 돤한 임상적 고찰", 7, pp.40~47 (2004)
  13. Gryboski J, "Gastrointestinal food allergy in infancy", 40, pp.354~62 (1967)
  14. Chang CH, "Chronic diarrhea in infancy:Analysis of 68 cases with particular reference to differential diagnosis and management", 32, pp.239~51 (1991)
  15. 노상수, "우유 및 두유의 불내성과 동반된 신생아 괴사성장염 1례", 35, pp.862~865 (1992)
  16. 박승희, "신생아기에 발생한 우유 알레르기에 관한 고찰", 36, pp.1383~8 (1993)
  17. 김희수, "영유아의 만성 설사에 대한 임상적 연구", 37, pp.212~20 (1994)
  18. 신종원, "생후 3개월내에 발생한 영아기 난치성 설사 환아의 임상소견 및 치료방침에 관한 임상적 고찰", 38, pp.936~945 (1995)
  19. 이정진, "위장관 증세 위주로 발현하는 영유아기 우유 알레르기 질환의 3가지 임상 유형에 관한 고찰", 3, pp.30~40 (2000)
  20. Hwang JB, "Indexes of suspicion of typical cow's milk protein- induced enterocolitis" (2007)
  21. Hwang JB, "The significance of gastric juice analysis for a positive challenge by a standard oral challenge test in typical cow's milk protein-induced enterocolitis" (2008)
  22. Nowak-Wegrzyn A, "Food protein-induced enterocolitis syndrome caused by solid food proteins", 111, pp.829~835 (2003)
  23. 황진복, "우유 단백질 유발성 장염의 소장 점막 조직의 형태학적 정량적 분석" (2005), 서울: 대한소아과학회
  24. Walker-Smith JA, "Cow milk-sensitive enteropathy:predisposing factors and treatment", 121 (1992)
  25. Heyman M, "Mononuclear cells from infants allergic to cow's milk secret tumor necrosis factor α,altering intestinal function", 106, pp.1514~23 (1994)
  26. Madara JL, "Interferon-γ directly affects barrier function of cultured intestinal epithelial monolayers", 83, pp.724~7 (1989)
  27. Hwang JB, "Analysis of enteropathy in cow's milk protein-induced enterocolitis and the role of TNF-family and tight junction in its pathogenesis" (2006), Tokyo: Asian Society for Pediatric Research
  28. Hwang JB, "Prospective follow up-oral food challenge and cow's milk and soy tolerance rates in infantile food protein-induced enterocolitis syndrome" (2007), Tokyo: Asian Society for Pediatric Research
  29. Sampson HA, "classification of gastrointestinal manifestations due to immunologic reactions to foods in infants and young children", 30(Suppl), pp.87S~94S (2000)
  30. Sicherer SH, "Clinical features of food protein-induced enterocolitis syndrome", 133, pp.214~219 (1998)
  31. Powell GK, "Milk- and soy-induced enterocolitis of infancy", pp.553~60
  32. Powell GK, "Food protein-induced enterocolitis of infancy", pp.28~37
  33. Burks AW, "Prospective oral food challenge study of two soybean protein isolates in patients with possible milk or soy protein enterocolitis", pp.40~5
  34. Powell GK, "Enterocolitis in low-birth-weight infants associated with milk and soy protein intolerance", pp.840~4
  35. Murray KF, "Dietary protein intolerance in infants with transient methemoglobinemia and diarrhea", pp.90~2
  36. McDonald PJ, "altered antibody response to ingested antigen", pp.751~5
  37. Chung HL, "Expression of transforming growth factor β1, transforming growth factor type I and II receptors, and TNF-α in the mucosa of the small intestine in infants with food protein-induced enterocolitis syndrome", 109, pp.150~154 (2002)
  38. Sicherer SH, "Food protein-induced enterocolitis syndrome: case presentations and management lessons", 115, pp.149~156 (2005)
  39. Fogg MI, "Atopy patch test for the diagnosis of food protein- induced enterocolitis", 17, pp.351~355 (2006)
  40. 황진복, "새로운 분류법에 따른 소아 위장관 우유 알레르기 질환에 돤한 임상적 고찰", 7, pp.40~47 (2004)
  41. "Gastrointestinal food allergy in infancy", pp.354~62
  42. Chang CH, "Chronic diarrhea in infancy Analysis of 68 cases with particular reference to differential diagnosis and management", pp.239~51
  43. 노상수, "우유 및 두유의 불내성과 동반된 신생아 괴사성장염 1례 소아과 1992;35", pp.862~865
  44. 박승희, "신생아기에 발생한 우유 알레르기에 관한 고찰 소아과 1993;36", pp.1383~8
  45. 김희수, "영유아의 만성 설사에 대한 임상적 연구 소아과 1994;37", pp.212~20
  46. 신종원, "생후 3개월내에 발생한 영아기 난치성 설사 환아의 임상소견 및 치료방침에 관한 임상적 고찰", 38, pp.936~945 (1995)
  47. 이정진, "위장관 증세 위주로 발현하는 영유아기 우유 알레르기 질환의 3가지 임상 유형에 관한 고찰", 3, pp.30~40 (2000)
  48. Hwang JB, "Indexes of suspicion of typical cow's milk protein- induced enterocolitis" (2007), In press
  49. Hwang JB, "The significance of gastric juice analysis for a positive challenge by a standard oral challenge test in typical cow's milk protein-induced enterocolitis" (2008), In press
  50. Nowak-Wegrzyn A, "Food protein-induced enterocolitis syndrome caused by solid food proteins", 111, pp.829~835 (2003)
  51. 황진복, "우유 단백질 유발성 장염의 소장 점막 조직의 형태학적 정량적 분석" (2005), 서울. 서울: 대한소아과학회
  52. Heyman M, "Mononuclear cells from infants allergic to cow's milk secret tumor necrosis factor α", pp.1514~23
  53. Madara JL, "Interferon-γ directly affects barrier function of cultured intestinal epithelial monolayers", pp.724~7
  54. Hwang JB, "Analysis of enteropathy in cow's milk protein-induced enterocolitis and the role of TNF-family and tight junction in its pathogenesis. Program and Abstracts, the 2nd Congress of Asian Society for Pediatric Research; 2006 Dec 8-10; Yokohama" (2006), Tokyo: Asian Society for Pediatric Research
  55. Hwang JB, "Prospective follow up-oral food challenge and cow's milk and soy tolerance rates in infantile food protein-induced enterocolitis syndrome" (2007), Tokyo. Tokyo: Asian Society for Pediatric Research, In press

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