본문 바로가기
KERD
논문KCI 등재

Gut Microbiota and Clinical Disease: Obesity and Nonalcoholic Fatty Liver Disease

2

조회

0

다운로드

3

인용

0

참고문헌

키워드

주제분류소아과학

초록

The prevalence of obesity is increasing worldwide. Obesity can cause hyperlipidemia, hypertension, cardiovasculardiseases, metabolic syndrome and non-alcoholic fatty liver disease (NAFLD). Many environmental or genetic factorshave been suggested to contribute to the development of obesity, but there is no satisfactory explanation for its increasedprevalence. This review discusses the latest updates on the role of the gut microbiota in obesity and NAFLD.(Pediatr Gastroenterol Hepatol Nutr 2013; 16: 22∼27)

Abstract

The prevalence of obesity is increasing worldwide. Obesity can cause hyperlipidemia, hypertension, cardiovasculardiseases, metabolic syndrome and non-alcoholic fatty liver disease (NAFLD). Many environmental or genetic factorshave been suggested to contribute to the development of obesity, but there is no satisfactory explanation for its increasedprevalence. This review discusses the latest updates on the role of the gut microbiota in obesity and NAFLD.(Pediatr Gastroenterol Hepatol Nutr 2013; 16: 22∼27)

참고문헌 (45)

  1. Conterno L, "Obesity and the gut microbiota: does up-regulating colonic fermentation protect against obesity and metabolic disease?", Genes Nutr, 6, pp.241~260 (2011)
  2. 오경원, "한국 소아청소년의 비만 유병률 추이: 1997년과 2005년 비교", Korean Journal of Pediatrics, 51(9), pp.950~955 (2008), 대한소아과학회
  3. 조성종, "소아 비만아의 사춘기 이후까지 장기간 추적 관찰", Pediatric Gastroenterology, Hepatology & Nutrition, 6(1), pp.47~53 (2003), 대한소아소화기영양학회
  4. Frazier TH, "Gut microbiota, intestinal permeability, obesity-induced inflammation, and liver injury", JPEN J Parenter Enteral Nutr, 35(5), pp.14S~20S (2011)
  5. 장진하, "소아비만증에서 대사 증후군의 유병률", Korean Journal of Pediatrics, 47(11), pp.1149~1156 (2004), 대한소아과학회
  6. 노한내, "한국 소아 청소년에서 비만 및 대사 이상의 유병률", Pediatric Gastroenterology, Hepatology & Nutrition, 12(2), pp.207~214 (2009), 대한소아소화기영양학회
  7. Tilg H, "Obesity and the microbiota", Gastroenterology, 136, pp.1476~1483 (2009)
  8. Ley RE, "Ecological and evolutionary forces shaping microbial diversity in the human intestine", Cell, 124, pp.837~848 (2006)
  9. Lyra A, "Benef Microbes", 1, pp.407~421 (2010)
  10. Abu-Shanab A, "The role of the gut microbiota in nonalcoholic fatty liver disease", Nat Rev Gastroenterol Hepatol, 7, pp.691~701 (2010)
  11. Machado MV, "Gut microbiota and nonalcoholic fatty liver disease", Ann Hepatol, 11, pp.440~449 (2012)
  12. Neish AS, "Microbes in gastrointestinal health and disease", Gastroenterology, 136, pp.65~80 (2009)
  13. Bäckhed F, "Host-bacterial mutualism in the human intestine", Science, 307, pp.1915~1920 (2005)
  14. Clemente JC, "The impact of the gut microbiota on human health: an integrative view", Cell, 148, pp.1258~1270 (2012)
  15. Krznarić Z, "Gut microbiota and obesity", Dig Dis, 30, pp.196~200 (2012)
  16. Zoetendal EG, "A microbial world within us", Mol Microbiol, 59, pp.1639~1650 (2006)
  17. Diamant M, "Do nutrient-gut-microbiota interactions play a role in human obesity, insulin resistance and type 2 diabetes?", Obes Rev, 12, pp.272~281 (2011)
  18. Ottman N, "The function of our microbiota: who is out there and what do they do?", Front Cell Infect Microbiol, 2, pp.104~ (2012)
  19. Ley RE, "Obesity alters gut microbial ecology", Proc Natl Acad Sci U S A, 102, pp.11070~11075 (2005)
  20. Turnbaugh PJ, "A core gut microbiome in obese and lean twins", Nature, 457, pp.480~484 (2009)
  21. Ley RE, "Obesity and the human microbiome", Curr Opin Gastroenterol, 26, pp.5~11 (2010)
  22. Kalliomäki M, "Early differences in fecal microbiota composition in children may predict overweight", Am J Clin Nutr, 87, pp.534~538 (2008)
  23. Balamurugan R, "Quantitative differences in intestinal Faecalibacterium prausnitzii in obese Indian children", Br J Nutr, 103, pp.335~338 (2010)
  24. Karlsson CL, "Thorngren-Jerneck K. The microbiota of the gut in preschool children with normal and excessive body weight", Obesity (Silver Spring), 20, pp.2257~2261 (2012)
  25. Luoto R, "Initial dietary and microbiological environments deviate in normal-weight compared to overweight children at 10 years of age", J Pediatr Gastroenterol Nutr, 52, pp.90~95 (2011)
  26. Luoto R, "The impact of perinatal probiotic intervention on the development of overweight and obesity: follow-up study from birth to 10 years", Int J Obes, 34, pp.1531~1537 (2010)
  27. Bäckhed F, "The gut microbiota as an environmental factor that regulates fat storage", Proc Natl Acad Sci, 101, pp.15718~15723 (2004)
  28. Bäckhed F, "Mechanisms underlying the resistance to diet-induced obesity in germ-free mice", Proc Natl Acad Sci, 104, pp.979~984 (2007)
  29. Turnbaugh PJ, "An obesity-associated gut microbiome with increased capacity for energy harvest", Nature, 444, pp.1027~1031 (2006)
  30. Samuel BS, "Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty- acid binding G protein-coupled receptor, Gpr41", Proc Natl Acad Sci, 105, pp.16767~16772 (2008)
  31. Daubioul CA, "Dietary oligofructose lessens hepatic steatosis, but does not prevent hypertriglyceridemia in obese zuckerrats", J Nutr, 130, pp.1314~1319 (2000)
  32. Delzenne NM, "A place for dietary fibre in the management of the metabolic syndrome", Curr Opin Clin Nutr Metab Care, 8, pp.636~640 (2005)
  33. Piche T, "Colonic fermentation influences lower esophageal sphincter function in gastroesophageal reflux disease", Gastroenterology, 124, pp.894~902 (2003)
  34. Cani PD, "Metabolic endotoxemia initiates obesity and insulin resistance", Diabetes, 56, pp.1761~1772 (2007)
  35. de La Serre CB, "Propensity to high-fat diet-induced obesity in rats is associated with changes in the gut microbiota and gut inflammation", Am J Physiol Gastrointest Liver Physiol, 299, pp.G440~448 (2010)
  36. Cani PD, "Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability", Gut, 58, pp.1091~1103 (2009)
  37. Spencer MD, "Association between composition of the human gastrointestinal microbiome and development of fatty liver with choline deficiency", Gastroenterology, 140, pp.976~986 (2011)
  38. Cope K, "Increased gastrointestinal ethanol production in obese mice: implications for fatty liver disease pathogenesis", Gastroenterology, 119, pp.1340~1347 (2000)
  39. Rivera CA, "Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis", J Hepatol, 47, pp.571~579 (2007)
  40. Swann JR, "Systemic gut microbial modulation of bile acid metabolism in host tissue compartments", Proc Natl Acad Sci, 108(1), pp.4523~4530 (2011)
  41. Sabaté JM, "High prevalence of small intestinal bacterial overgrowth in patients with morbid obesity: a contributor to severe hepatic steatosis", Obes Surg, 18, pp.371~377 (2008)
  42. Miele L, "Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease", Hepatology, 49, pp.1877~1887 (2009)
  43. Verdam FJ, "Novel evidence for chronic exposure to endotoxin in human nonalcoholic steatohepatitis", J Clin Gastroenterol, 45, pp.149~152 (2011)
  44. Tsukumo DM, "Translational research into gut microbiota: new horizons in obesity treatment", Arq Bras Endocrinol Metabol, 53, pp.139~144 (2009)
  45. Iacono A, "Probiotics as an emerging therapeutic strategy to treat NAFLD: focus on molecular and biochemical mechanisms", J Nutr Biochem, 22, pp.699~711 (2011)

관련 논문AI추천

이 간행물의 다른 논문 (9건)