Gut Microbiota in Inflammatory Bowel Disease
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
The gut mucosal barrier plays an important role in maintaining a delicate immune homeostasis. The pathogenesisof inflammatory bowel disease (IBD) is considered to involve a defective mucosal immunity along with a geneticpredisposition. Recent views have suggested an excessive response to components of the gut microbiota in IBD. A condition of “dysbiosis”, with alterations of the gut microbial composition, has been observed in patients with IBD. In this article, the author review recent studies of gut microbiota in IBD, particularly the importance of the gut microbiotain the pathogenesis of pediatric IBD. (Pediatr Gastroenterol Hepatol Nutr 2013; 16: 17∼21)
Abstract
The gut mucosal barrier plays an important role in maintaining a delicate immune homeostasis. The pathogenesisof inflammatory bowel disease (IBD) is considered to involve a defective mucosal immunity along with a geneticpredisposition. Recent views have suggested an excessive response to components of the gut microbiota in IBD. A condition of “dysbiosis”, with alterations of the gut microbial composition, has been observed in patients with IBD. In this article, the author review recent studies of gut microbiota in IBD, particularly the importance of the gut microbiotain the pathogenesis of pediatric IBD. (Pediatr Gastroenterol Hepatol Nutr 2013; 16: 17∼21)
참고문헌 (24)
- 서정기, "소아기에 발병하는 염증성장질환(IBD)은 성인 IBD와 다른 질환인가? - 조기발병 소아 IBD의 역학적, 임상적, 유전학적 특성 및 치료 시 고려 사항-", Pediatric Gastroenterology, Hepatology & Nutrition, 14(1), pp.1~25 (2011), 대한소아소화기영양학회
- Taurog JD, "The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats", J Exp Med, 180, pp.2359~2364 (1994)
- Abraham C, "Interactions between the host innate immune system and microbes in inflammatory bowel disease", Gastroenterology, 140, pp.1729~1737 (2011)
- Aldhous MC, "Gene-environmental interactions in inflammatory bowel disease: microbiota and genes", Frontline Gastroenterology, 3, pp.180~186 (2012)
- Thomazini CM, "High prevalence of aggregative adherent Escherichia coli strains in the mucosa-associated microbiota of patients with inflammatory bowel diseases", Int J Med Microbiol, 301, pp.475~479 (2011)
- Lapaquette P, "Crohn's disease-associated adherent- invasive E. coli are selectively favoured by impaired autophagy to replicate intracellularly", Cell Microbiol, 12, pp.99~113 (2010)
- Andersson U, "High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes", J Exp Med, 192, pp.565~570 (2000)
- Manichanh C, "Reduced diversity of faecal microbiota in Crohn's disease revealed by a metagenomic approach", Gut, 55, pp.205~211 (2006)
- Seksik P, "Alterations of the dominant faecal bacterial groups in patients with Crohn's disease of the colon", Gut, 52, pp.237~242 (2003)
- Willing BP, "A pyrosequencing study in twins shows that gastrointestinal microbial profiles vary with inflammatory bowel disease phenotypes", Gastroenterology, 139, pp.1844~1854e1 (2010)
- Hammer HF, "Gut microbiota and inflammatory bowel disease", Dig Dis, 29, pp.550~553 (2011)
- Iebba V, "Gut microbiota and pediatric disease", Dig Dis, 29, pp.531~539 (2011)
- Swidsinski A, "Mucosal flora in inflammatory bowel disease", Gastroenterology, 122, pp.44~54 (2002)
- Chassaing B, "The commensal microbiota and enteropathogens in the pathogenesis of inflammatory bowel diseases", Gastroenterology, 140, pp.1720~1728 (2011)
- Negroni A, "Characterization of adherent-invasive Escherichia coli isolated from pediatric patients with inflammatory bowel disease", Inflamm Bowel Dis, 18, pp.913~924 (2012)
- Frank DN, "Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases", Proc Natl Acad Sci, 104, pp.13780~13785 (2007)
- Nagalingam NA, "Role of the microbiota in inflammatory bowel diseases", Inflamm Bowel Dis, 18, pp.968~984 (2012)
- Meyer AM, "The diagnostic yield of stool pathogen studies during relapses of inflammatory bowel disease", J Clin Gastroenterol, 38, pp.772~775 (2004)
- Michail S, "Alterations in the gut microbiome of children with severe ulcerative colitis", Inflamm Bowel Dis, 18, pp.1799~1808 (2012)
- Hugot JP, "Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease", Nature, 411, pp.599~603 (2001)
- Maloy KJ, "Intestinal homeostasis and its breakdown in inflammatory bowel disease", Nature, 474, pp.298~306 (2011)
- Frank DN, "Disease phenotype and genotype are associated with shifts in intestinal-associated microbiota in inflammatory bowel diseases", Inflamm Bowel Dis, 17, pp.179~184 (2011)
- Brant SR, "A population-based case-control study of CARD15 and other risk factors in Crohn's disease and ulcerative colitis", Am J Gastroenterol, 102, pp.313~323 (2007)
- Landy J, "Review article: faecal transplantation therapy for gastrointestinal disease", Aliment Pharmacol Ther, 34, pp.409~415 (2011)
