Gastritis Associated with Initially Pediatric Crohn’s Disease andUlcerative Colitis
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Purpose: The aim of this study is to determine the involvement of the upper gastrointestinal system (GIS) in patients diagnosed with Crohn’s disease (CD), ulcerative colitis (UC), and non-inflammatory bowel disease (IBD) and to com-pare their differences. Methods: This study included patients aged between 2 and 18 years who underwent colonoscopy and esophagogas-troduodenoscopy (EGD) for the first time due to the prediagnosis of IBD. In EGD, samples were taken from duodenum, antrum, corpus, and esophagus; and gastritis, duodenitis, and esophagitis were identified through histopathologic examination. The data gathered the ends of the research were compared between IBD with non-IBD groups and between CD-UC with non-IBD groups, and the presence of significant differences between groups were determined. Results: In our study, 16 patients were diagnosed with CD, 13 with UC, 3 with undeterminate colitis, and 13 with non-IBD. In the histopathological examination of the groups, GIS involvement was found in 94.1% of patients diag-nosed with IBD and in 38.5% of non-IBD patients. Moreover, the difference was found to be statistically significant (p=0.032). No significant difference was found between the CD and UC groups. Gastritis was mostly observed in 93.8% of CD-diagnosed patients, 76.8% of UC-diagnosed patients, 81.2% of IBD-diagnosed patients, and 38.5% of non-IBD–diagnosed patients. On the other hand, significant differences were found between CD and non-IBD groups (p=0.03), UC and non-IBD groups (p=0.047), and IBD and non-IBD groups (p=0.03). Conclusion: The results of the study show that gastritis was highly observed in UC- and CD-diagnosed patients than in non-IBD–diagnosed patients.
Abstract
Purpose: The aim of this study is to determine the involvement of the upper gastrointestinal system (GIS) in patients diagnosed with Crohn’s disease (CD), ulcerative colitis (UC), and non-inflammatory bowel disease (IBD) and to com-pare their differences. Methods: This study included patients aged between 2 and 18 years who underwent colonoscopy and esophagogas-troduodenoscopy (EGD) for the first time due to the prediagnosis of IBD. In EGD, samples were taken from duodenum, antrum, corpus, and esophagus; and gastritis, duodenitis, and esophagitis were identified through histopathologic examination. The data gathered the ends of the research were compared between IBD with non-IBD groups and between CD-UC with non-IBD groups, and the presence of significant differences between groups were determined. Results: In our study, 16 patients were diagnosed with CD, 13 with UC, 3 with undeterminate colitis, and 13 with non-IBD. In the histopathological examination of the groups, GIS involvement was found in 94.1% of patients diag-nosed with IBD and in 38.5% of non-IBD patients. Moreover, the difference was found to be statistically significant (p=0.032). No significant difference was found between the CD and UC groups. Gastritis was mostly observed in 93.8% of CD-diagnosed patients, 76.8% of UC-diagnosed patients, 81.2% of IBD-diagnosed patients, and 38.5% of non-IBD–diagnosed patients. On the other hand, significant differences were found between CD and non-IBD groups (p=0.03), UC and non-IBD groups (p=0.047), and IBD and non-IBD groups (p=0.03). Conclusion: The results of the study show that gastritis was highly observed in UC- and CD-diagnosed patients than in non-IBD–diagnosed patients.
참고문헌 (32)
- Satsangi J, "The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications", Gut, 55, pp.749~753 (2006)[DOI]
- Hadithi M, "Retrospective analysis of old-age colitis in the Dutch inflammatory bowel disease population", World J Gastroenterol, 14, pp.3183~3187 (2008)[DOI]
- Blumberg RS, "Prospects for research in inflammatory bowel disease", JAMA, 285, pp.643~647 (2001)[DOI]
- Levine A, "Pediatric modification of the Montreal classification for inflammatory bowel disease: the Paris classification", Inflamm Bowel Dis, 17, pp.1314~1321 (2011)[DOI]
- Odze R, "Diagnostic problems and advances in inflammatory bowel disease", Mod Pathol, 16, pp.347~358 (2003)[DOI]
- Tobin JM, "Upper gastrointestinal mucosal disease in pediatric Crohn disease and ulcerative colitis: a blinded, controlled study", J Pediatr Gastroenterol Nutr, 32, pp.443~448 (2001)[DOI]
- Lemberg DA, "Role of esophagogastroduodenoscopy in the initial assessment of children with inflammatory bowel disease", J Gastroenterol Hepatol, 20, pp.1696~1700 (2005)[DOI]
- Castellaneta SP, "Diagnostic role of upper gastrointestinal endoscopy in pediatric inflammatory bowel disease", J Pediatr Gastroenterol Nutr, 39, pp.257~261 (2004)[DOI]
- Abdullah BA, "The role of esophagogastroduodenoscopy in the initial evaluation of childhood inflammatory bowel disease: a 7-year study", J Pediatr Gastroenterol Nutr, 35, pp.636~640 (2002)[DOI]
- Sawczenko A, "Presenting features of inflammatory bowel disease in Great Britain and Ireland", Arch Dis Child, 88, pp.995~1000 (2003)[DOI]
- Hori K, "Gastroduodenitis associated with ulcerative colitis", J Gastroenterol, 43, pp.193~201 (2008)[DOI]
- Levine A, "ESPGHAN revised porto criteria for the diagnosis of inflammatory bowel disease in children and adolescents", J Pediatr Gastroenterol Nutr, 58, pp.795~806 (2014)
- Diefenbach KA, "Pediatric inflammatory bowel disease", World J Gastroenterol, 12, pp.3204~3212 (2006)[DOI]
- North American Society for Pediatric Gastroenterology, "Differentiating ulcerative colitis from Crohn disease in children and young adults: report of a working group of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the Crohn's and Colitis Foundation of America", J Pediatr Gastroenterol Nutr, 44, pp.653~674 (2007)[DOI]
- Stolte M, "The updated Sydney system: classification and grading of gastritis as the basis of diagnosis and treatment", Can J Gastroenterol, 15, pp.591~598 (2001)[DOI]
- Price AB, "The Sydney system: histological division", J Gastroenterol Hepatol, 6, pp.209~222 (1991)[DOI]
- Hassan TMM, "Helicobacter pylori chronic gastritis updated Sydney grading in relation to endoscopic findings and H. pylori IgG antibody: diagnostic methods", J Microsc Ultrastruct, 4, pp.167~174 (2016)[DOI]
- Petrolla AA, "The clinical significance of focal enhanced gastritis in adults with isolated ileitis of the terminal ileum", J Gastroenterol, 43, pp.524~530 (2008)[DOI]
- Parente F, "Focal gastric inflammatory infiltrates in inflammatory bowel diseases: prevalence, immunohistochemical characteristics, and diagnostic role", Am J Gastroenterol, 95, pp.705~711 (2000)[DOI]
- Yanaoka K, "Eradication of Helicobacter pylori prevents cancer development in subjects with mild gastric atrophy identified by serum pepsinogen levels", Int J Cancer, 125, pp.2697~2703 (2009)[DOI]
- Day DW, "Morson and Dawson's gastrointestinal pathology", pp.308~ (2003), Blackwell Publishing
- Roka K, "The value of focally enhanced gastritis in the diagnosis of pediatric inflammatory bowel diseases", J Crohns Colitis, 7, pp.797~802 (2013)[DOI]
- Hummel TZ, "Additional value of upper GI tract endoscopy in the diagnostic assessment of childhood IBD", J Pediatr Gastroenterol Nutr, 54, pp.753~757 (2012)[DOI]
- Kovacs M, "Diagnostic yield of upper endoscopy in paediatric patients with Crohn's disease and ulcerative colitis. Subanalysis of the HUPIR registry", J Crohns Colitis, 6, pp.86~94 (2012)[DOI]
- Sonnenberg A, "Frequent occurrence of gastritis and duodenitis in patients with inflammatory bowel disease", Inflamm Bowel Dis, 17, pp.39~44 (2011)[DOI]
- Genta RM, "Helicobacter pylori-negative chronic active gastritis: a new entity or the result of widespread acid inhibition?", Gastroenterology, 134, pp.858~ (2008)
- Kundhal PS, "Gastral antral biopsy in the differentiation of pediatric colitides", Am J Gastroenterol, 98, pp.557~561 (2003)[DOI]
- Ruuska T, "Prospective evaluation of upper gastrointestinal mucosal lesions in children with ulcerative colitis and Crohn's disease", J Pediatr Gastroenterol Nutr, 19, pp.181~186 (1994)[DOI]
- Sharif F, "Focally enhanced gastritis in children with Crohn's disease and ulcerative colitis", Am J Gastroenterol, 97, pp.1415~1420 (2002)[DOI]
- el-Omar E, "Low prevalence of Helicobacter pylori in inflammatory bowel disease: association with sulphasalazine", Gut, 35, pp.1385~1388 (1994)[DOI]
- Piodi LP, "Possible protective effect of 5-aminosalicylic acid on Helicobacter pylori infection in patients with inflammatory bowel disease", J Clin Gastroenterol, 36, pp.22~25 (2003)[DOI]
- Prenzel F, "Frequency of indeterminate colitis in children and adults with IBD - a metaanalysis", J Crohns Colitis, 3, pp.277~281 (2009)[DOI]