Characteristics and Treatment Outcomes of Transition among Patients with Inflammatory Bowel Disease
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Purpose: This study aimed to assess disease characteristics and outcomes of transition in patient care among adolescent patients with inflammatory bowel disease (IBD). Materials and Methods: Data from patients younger than 18 years who were diagnosed with IBD (Crohn’s disease, ulcerative colitis, or intestinal Behçet’s disease) were investigated. We categorized the patients into two groups: transition IBD group (Group A, diagnosed in pediatric care followed by transfer to/attendance in adult IBD care) and non-transition group (Group B, diag nosed and followed up in pediatric care or adult IBD care without transfer). Results: Data from a total of 242 patients [Group A (n=29, 12.0%), Group B (n=213, 88.0%)] were analyzed. A significantly higher number of patients was diagnosed at an earlier age in Group A than in Group B (p<0.001). Group A patients had more severe dis ease in terms of number of disease flare ups (p=0.011) and frequency of bowel-related complications (p<0.001). Multiple linear re gression analysis showed that Group B patients had more medical non-compliance than Group A patients (β=2.31, p=0.018). After transition, IBD-related admission frequency, emergency admission frequency, disease flare frequency, and medical non-compli ance were significantly improved. Conclusion: The transition IBD group had more severe disease. Medical non-compliance was lower in the transition IBD group. Clinical outcomes improved after transition.
Abstract
Purpose: This study aimed to assess disease characteristics and outcomes of transition in patient care among adolescent patients with inflammatory bowel disease (IBD). Materials and Methods: Data from patients younger than 18 years who were diagnosed with IBD (Crohn’s disease, ulcerative colitis, or intestinal Behçet’s disease) were investigated. We categorized the patients into two groups: transition IBD group (Group A, diagnosed in pediatric care followed by transfer to/attendance in adult IBD care) and non-transition group (Group B, diag nosed and followed up in pediatric care or adult IBD care without transfer). Results: Data from a total of 242 patients [Group A (n=29, 12.0%), Group B (n=213, 88.0%)] were analyzed. A significantly higher number of patients was diagnosed at an earlier age in Group A than in Group B (p<0.001). Group A patients had more severe dis ease in terms of number of disease flare ups (p=0.011) and frequency of bowel-related complications (p<0.001). Multiple linear re gression analysis showed that Group B patients had more medical non-compliance than Group A patients (β=2.31, p=0.018). After transition, IBD-related admission frequency, emergency admission frequency, disease flare frequency, and medical non-compli ance were significantly improved. Conclusion: The transition IBD group had more severe disease. Medical non-compliance was lower in the transition IBD group. Clinical outcomes improved after transition.
참고문헌 (35)
- Lehtinen P, "Incidence trends of pediatric inflammatory bowel disease in Finland, 1987-2003, a nationwide study", Inflamm Bowel Dis, 17, pp.1778~1783 (2011)
- Benchimol EI, "Changes to surgical and hospitalization rates of pediatric inflammatory bowel disease in Ontario, Canada(1994-2007)", Inflamm Bowel Dis, 17, pp.2153~2161 (2011)
- Van Limbergen J, "Definition of phenotypic characteristics of childhood-onset inflammatory bowel disease", Gastroenterology, 135, pp.1114~1122 (2008)
- Rosen DS, "Pubertal growth and sexual maturation for adolescents with chronic illness or disability", Pediatrician, 18, pp.105~120 (1991)
- Escher JC, "Transition from pediatric to adult health care in inflammatory bowel disease", Dig Dis, 27, pp.382~386 (2009)
- Jeganathan J, "Pediatric-to-adult transition and medication adherence in patients with inflammatory bowel disease", Inflamm Bowel Dis, 23, pp.1065~1070 (2017)
- Timmer A, "A surveybased index was validated for measuring disease activity in inflammatory bowel disease. An evaluation study", J Clin Epidemiol, 62, pp.771~778 (2009)
- Jin Soo Moon, "Clinical Aspects and Treatments for Pediatric Inflammatory Bowel Diseases", Pediatric Gastroenterology, Hepatology & Nutrition, 22(1), pp.50~56 (2019), 대한소아소화기영양학회[DOI]
- Cheon JH, "Development, validation, and responsiveness of a novel disease activity index for intestinal Behçet’s disease", Inflamm Bowel Dis, 17, pp.605~613 (2011)
- Cole R, "Evaluation of outcomes in adolescent inflammatory bowel disease patients following transfer from pediatric to adult health care services : case for transition", J Adolesc Health, 57, pp.212~217 (2015)
- Hommel KA, "Objective versus subjective assessment of oral medication adherence in pediatric inflammatory bowel disease", Inflamm Bowel Dis, 15, pp.589~593 (2009)
- Rosen D, "Transition of inflammatory bowel disease care : assessment of transition readiness factors and disease outcomes in a young adult population", Inflamm Bowel Dis, 22, pp.702~708 (2016)
- Leung Y, "Transitioning the adolescent inflammatory bowel disease patient : guidelines for the adult and pediatric gastroenterologist", Inflamm Bowel Dis, 17, pp.2169~2173 (2011)
- Reid GJ, "Prevalence and correlates of successful transfer from pediatric to adult health care among a cohort of young adults with complex congenital heart defects", Pediatrics, 113(3 Pt 1), pp.e197~e205 (2004)
- Otto C, "Planned transition of adolescent patients with inflammatory bowel disease results in higher remission rates", J Pediatr Nurs, 45, pp.62~66 (2019)
- Fu N, "Transition clinic attendance is associated with improved beliefs and attitudes toward medicine in patients with inflammatory bowel disease", World J Gastroenterol, 23, pp.5405~5411 (2017)
- Bennett AL, "Outcomes and patients’ perspectives of transition from paediatric to adult care in inflammatory bowel disease", World J Gastroenterol, 22, pp.2611~2620 (2016)
- Ng SC, "Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century : a systematic review of populationbased studies", Lancet, 390, pp.2769~2778 (2017)
- Bernice Tan, "Pediatric to adult inflammatory bowel disease transition: the Asian experience", Intestinal research, 18(1), pp.11~17 (2020), 대한장연구학회
- Herzog D, "Prevalence of intestinal complications in inflammatory bowel disease : a comparison between paediatric-onset and adult-onset patients", Eur J Gastroenterol Hepatol, 29, pp.926~931 (2017)
- 김영선, "Impact of inflammatory bowel disease on daily life: an online survey by the Korean Association for the Study of Intestinal Diseases", Intestinal research, 15(3), pp.338~344 (2017), 대한장연구학회
- 오신주, "Long-term outcomes of infliximab in a real-world multicenter cohort of patients with acute severe ulcerative colitis", Intestinal research, 19(3), pp.323~331 (2021), 대한장연구학회[DOI]
- Yasuo Suzuki, "Long-term safety and effectiveness of adalimumab in 462 patients with intestinal Behçet’s disease: results from a large real-world observational study", Intestinal research, 19(3), pp.301~312 (2021), 대한장연구학회[DOI]
- Mackner LM, "Oral medication adherence in pediatric inflammatory bowel disease", Inflamm Bowel Dis, 11, pp.1006~1012 (2005)
- McGrady ME, "Medication adherence and health care utilization in pediatric chronic illness : a systematic review", Pediatrics, 132, pp.730~740 (2013)
- Koster ES, "Adolescents’ inhaled corticosteroid adherence : the importance of treatment perceptions and medication knowledge", J Asthma, 52, pp.431~436 (2015)
- Kipps S, "Current methods of transfer of young people with type 1 diabetes to adult services", Diabet Med, 19, pp.649~654 (2002)
- Watson AR, "Non-compliance and transfer from paediatric to adult transplant unit", Pediatr Nephrol, 14, pp.469~472 (2000)
- Nakhla M, "Transition to adult care for youths with diabetes mellitus : findings from a universal health care system", Pediatrics, 124, pp.e1134~e1141 (2009)
- 박상형, "Update on the epidemiology of inflammatory bowel disease in Asia: where are we now?", Intestinal research, 20(2), pp.159~164 (2022), 대한장연구학회[DOI]
- Koh Seong-Joon, "Korean clinical practice guidelines on biologics for moderate to severe Crohn’s disease", Intestinal research, 21(1), pp.43~60 (2023), 대한장연구학회[DOI]
- 나수영, "Korean clinical practice guidelines on biologics and small molecules for moderate-to-severe ulcerative colitis", Intestinal research, 21(1), pp.61~87 (2023), 대한장연구학회[DOI]
- Baldassano R, "Transition of the patient with inflammatory bowel disease from pediatric to adult care : recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition", J Pediatr Gastroenterol Nutr, 34, pp.245~248 (2002)
- Kumagai H, "Transitional care for patients with inflammatory bowel disease : Japanese experience", Digestion, 102, pp.18~24 (2021)
- Jeongseok Kim, "Successful Transition from Pediatric to Adult Care in Inflammatory Bowel Disease: What is the Key?", Pediatric Gastroenterology, Hepatology & Nutrition, 22(1), pp.28~40 (2019), 대한소아소화기영양학회[DOI]
