항정신병약물로 인한 QTc 지연과 5-HTTLPR의 연관성
Association of Antipsychotic-Induced QTc Prolongation with 5-HTTLPR
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키워드
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Abstract
A Comparison of QTc prolongation for various antipsychotics and an analysis of QTc prolongation for the various types of serotonin transporter polymorphism were performed. Method：EKG was checked, followed by QTc measurement as Bazett’s correction, and the serotonin transporter polymorphism was examined in 110 chronic schizophrenia patients were performed EKG before 24 weeks ago. We defiened QTc prolongation as over 450ms. The risk factor of sudden cardiac death were defiend as QTc prolongation and or 60ms in delta value. Result：The prevalence of QTc prolongation in this study was 7.3%, and the prevalence of over 60ms was 4.5%. Patients who had the risk factors were 10(9.1%). 6/52 who prescribed atypical antipsychotics and 2/58 who prescribed haloperidol showed QTc prolongation. The prevalence who had the risk factor of sudden cardiac death were 16% in atypical antipsychotics group, 3.4% in haloperidol group. QTc prolongation were observed more frequently in l/l type than s/s type. l allele frequency were 50% in QTc prolongated group, 19% in not prolongated group. l allele had an association with QTc prolongation(p<0.01). Conclusion：The prevalence of QTc prolongatin was frequent in chronic schizophrenia patients who were prescribed atypical antipsychotics. It has strong association with l allele of 5-HTTLPR.
참고문헌 (20)
- "Antipsychotic Drugs: ProlongedQTc interval,Torsade de Pointes, and suddendeath", 158, pp.1774~1782 (2001)
- "Asurvey of sudden death associated with the use of antipsychoticor antidepressant drugs 49 casese in Finland", pp.58~64
- "Antipsychotics and QT proongation", 107, pp.85~95 (2003)
- "Long QT syndromes and Torsae de Pointes", 354, pp.1625~1633 (1999)
- "The effect of thioridazine hydrochlorideand chlorpromazine on the electrocardiogram", pp.134~138
- "Electrocardiographicabnormalities in patients treated with clozapne", 61, pp.441~446 (2000)
- "The QT interval and the atypicalantipsychotic, sertindole. Int J Psychiatry Clin", 2, pp.265~273 (1998)
- "Serotonin and the heart", 32, pp.195~209 (2000)
- "Polymorphism ofthe serotonin transporter: implications the use of selectiveserotonin reuptake inhibitors", 1, pp.153~164 (2001)
- "Allelic variation in the serotonintransporter promoter affects neuromodulatory effects ofa selevtive(SSRI).", 166, pp.294~297 (2003)
- "An analysis of time relations of electrocardiograms", pp.353~367
- "Tolerability andcardiovascular safety of risperidone. Poster presented atthe 6th world Congress of Biological Psychiatry" (1997), Nice
- "Risperidone side effect", 61, pp.20~23 (2000)
- "Risperidone overdose", 154, pp.289~290 (1997)
- "Antipsychotic-related QTcprolongation, torsade de pointes and sudden death.", 62, pp.1649~1671 (2002)
- "A case of risperidoneoverdose in early schizophrenia :a review of potentialcomplications", 23, pp.305~308 (1998)
- "Recent studies on ECG changes antipsychotic use and sudden death in psychiatric patients", 26, pp.110~112 (2002)
- "Serotonin transporter gene polymorphism and antidepressantresponse.", 11, pp.215~219 (2000)
- "Genetic variation in the serotonin transporterpromoter region affects serotonin uptake in humanblood platelets", 88, pp.83~87 (1999)
- -serotonin uptakestudy in Korean depressed patients, , 2003, 54~60