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정신분열병 환자에서의 혈중 Homocysteine 농도와 MTHFR C677T, A1298C의 유전자 다형성

Serum Homocysteine Level and MTHFR C677T, A1298C Gene Polymorphism in Korean Schizophrenics

나철|이영식|전창무|채석래
대한생물정신의학회 (The Korean Society Of Biological Psychiatry)|2005.11|생물정신의학 (Journal of Korean Society of Biological Psychiatry)|제12권 제2호|pp. 36-45

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참고문헌

키워드

정신분열병·Homocysteine·MTHFR·유 전자다형성.Schizophrenia·Homocysteine·MTHFR·Polymorphism.
주제분류정신과학

초록

Abstract

objectives：Recently in schizophrenia high incidence of MTHFR methylenetetrahydrofolate reductase), which is a main relating enzyme that reduce homocysteine level, genetic variations were reported. So we examined serum homocysteine level and MTHFR gene polymorphism in Korean schizophrenics. Method：We compared serum homocysteine level and MTHFR polymorphism between 235 schizophrenics (100male, 135female) and 235 normal controls(100male, 135female). C677T and A1298C polymorphism of MTHFR gene were analyzed. Results：1) C677T genetic mutation(CT and TT) were more frequent in schizophrenia group than normal control group(p<0.01). But the difference of A1298C mutation frequency was not found between two groups. 2) In schizophrenia patients, TT genotype of C677T mutation showed significantly higher homocysteine level 29.99uM/L) than other group(CT：13.34uM/L, CC：9.34uM/L p<0.01). 3) MTHFR 677 TT homogeneous mutation genotype showed two times more risk(odds ratio=2.15) than 677CC normal genotype in schizophrenia. Conclusion：Some schizophrenia patients with high homocysteine serum level may have C677T TT genotype. In that case, folate ingestion could be a good management for clinical improvement.

참고문헌 (23)

  1. "Homocysteinemia is a common featureof schizophrenia", 100, pp.165~169 (1995)
  2. "Elevated homocysteine levels in youngmale patients with schizophrenia", 159, pp.1790~1792 (2002)
  3. "Plasma homocysteine and the methylenetetrahydrofolatereductase C677T gene variant:Lack of association with schizophrenia", 10, pp.2035~2038 (1999)
  4. "N-5,10-methylenetetrahydrofolatereductase deficiency and schizophrenia:A workinghypothesis", 11, pp.259~262 (1974)
  5. "A defectin methylation due to deficient 5", pp.10 491~496
  6. "Homocysteinemiaand schizophrenia as a case of methylationdeficiency", 98, pp.143~152 (1994)
  7. "Platelet methylene reductase activityin schizophrenia", 34, pp.808~809 (1977)
  8. "Human methylenetetrahydrofolatereductase:Isolation of cDNA,mappingand mutation identification", 7, pp.195~200 (1994)
  9. "A candidate genetic risk factorfor vascular disease:A common mutation in methylenetetrahydrofolatereductase", 10, pp.111~113 (1995)
  10. "Relation betweenfolate status,a common mutation in methylenetetrahydrofolatereductase,and plasma homocysteine concentrations", 93, pp.7~9 (1996)
  11. "Methylenetetrahydrofolate reductasevariant and schizophrenia", depression, 1997, pp.74, 526~528
  12. "The 1298A-->C polymorphismin methylenetetrahydrofolate reductase(MTHFR)In vitro expression and association with homocysteine", 156, pp.409~415 (2001)
  13. "정신분열병 환자에서의 혈중 homocysteine,엽산,VitamineB12 농도 비교연구", 11, pp.111~120 (2004)
  14. "Diagnostic and statisticalmanual of mental disorders. 4th ed. text revision(DSM-IV-TR)." (2000), American PsychiatricPress
  15. "Majorlifestyle determinants of plasma total homocysteine distribution:The Hordaland Homocysteine Study", 67, pp.263~270 (1998)
  16. "pig and rat and subcellular distribution in the rat", pp.551~556 (1991)
  17. "Homocysteine and atherothrombosis", 338, pp.1042~1050 (1998)
  18. "Symptomaticand asymptomatic methylenetetrahydrofolate reductasedeficiency in two adult brothers", 45, pp.572~576 (1993)
  19. "Inherited disorders of folate transportand metabolism. In: Scriver CR, Beaudet AL, Sly WS,Valle D, editors. The metabolic and molecular bases oinherited disease", pp.116~160 (1995), McGraw-Hill
  20. "Mutated methylenetetrahydrofolate reductase as a riskfactor for spina bifida", 346, pp.1070~1071 (1995)
  21. "A genetic defect in 5,10methylenetetrahydrofolate reductase in neural tube defects", 88, pp.763~766 (1995)
  22. "Methylenetetrahydrofolate reductaseC677T mutation,plasma homocysteine,and folate insubjects from northern Italy with or without angiographicallydocumented severe coronary atherosclerotic disease:Evidence for an important genetic-environmental interaction", 91, pp.4158~4163 (1998)
  23. "Homozygous thermolabile methylenetetrahydrofolatereductase in schizophrenia-like psychosis", 104, pp.931~941 (1997)

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