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논문KCI 등재

한국인 남자에서 Synapsin III 유전자의 D22S280 표지자와 정신분열병의 연합연구

No Associations between Schizophrenia and D22S280 Marker on Synapsin III gene in Korean Males.

홍경수|이승연|박종원|박용범|이석진|양병환|유장근|신윤식|이유상
대한생물정신의학회 (The Korean Society Of Biological Psychiatry)|2006.11|생물정신의학 (Journal of Korean Society of Biological Psychiatry)|제13권 제4호|pp. 256-262

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참고문헌

주제분류정신과학

초록

Abstract

Objectives: Synapsin III near VCFS region on 22q, of which role is affecting synaptic vesicle formation and neurodevelopment. It could be an interesting candidate gene for schizophrenia. D22S280 is a highly polymorphic genetic marker residing in synapsin III. We examined association of D22S280 marker on synapsin III with Korean patients with schizophrenia. Methods: The subjects were 46 male Korean patients with schizophrenia and 60 male normal controls. Using polymerase chain reaction, gel electrophoresis, ABI 310 genetic analyzer, and GeneScan Collection 3.1 software, we confirmed genotypes of D22S280 marker. We examined Hardy-Weinberg equilibrium and case-control association using SAS/Genetic 9.1.3. Results: Genotypes of both schizophrenia and control groups were in Hardy-Weinberg equilibrium. We could not find any significant statistical differences in allele-wise (χ2=10.4, df=6, p=0.098) and genotype-wise (χ2=22.1 df=19, p=0.258) analyses of D22S280 marker between schizophrenia and normal controls. Individual allele analyses with df=1 showed significant differences in A1 (p=0.025) and A7 (p=0.034) allele, which were not significant following Bonferroni corrections (A1: p=0.177, A7: p=0.235).Conclusion: We couldnt find any association between schizophrenia and synapsin III gene. Considering the limitation of small number of subjects, further investigations are needed.

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