정신분열병 환자에서 정신병적 증상과 인지기능의 관련성
Relationships between Psychotic Symptoms and Cognitive Functions in Schizophrenic Patients
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정신병적 증상과 인지기능 간의 상관은 전두엽성 정신병 증상들(음성증상, 와해증상)과 전두엽성 인지기능(실행기능, 회상기억) 사이에서 가장 일관성 있게 유의하였다. 이는 정신병적 증상과 인지기능의 상관이 주로 ‘전두엽 이상’에 있어서의 환자간 개인차에 의해 매개됨을 시사한다. 즉‘전두엽 이상’이 심한 정신분열병 환자일수록 전두엽성 정신병 증상이 심한 수준이고 전두엽성 인지기능의 결손도 심할 것이다. 반면에 ‘전두엽 이상’이 약한 정신분열병 환자일수록 전두엽성 정신병 증상이 약한 수준이고 전두엽성 인지기능의 결손도 낮을 것이다. 이러한 가설의 보다 실증적인 검증을 위해서는 정신병적 증상과 인지기능의 측정치 외에 전두엽에 대한 구조적 또는 기능적 측정치가 필요하다. 그러므로 향후 연구에서는 정신병적 증상, 인지기능, 신경영상 측정을 모두 포함하는 종합적 접근이 요구된다.감사의 글
Abstract
Objectives : The aim of this study was to investigate relationships between psychotic symptoms and cognitive functions in schizophrenia. Methods : The study group was composed of 36 schizophrenic patients. Positive, negative, and disorganization symptoms were assessed using PANSS. Verbal, visuospatial, attention, memory, and executive functions were assessed using a battery of cognitive tests. Results : Correlation analysis between symptom vs. cognitive measures showed that (a) positive symptoms were significantly correlated with no cognitive measures, negative symptoms were significantly correlated with all cognitive measures, and (c) disorganization symptoms were significantly correlated with executive and memory measures. Correlation analyses between symptom vs. cognitive factors showed that negative-disorganization factor is significantly correlated with executive-memory factor.Conclusion : Significant relationships were confined mostly to frontal-related symptoms vs. cognitive functions. Thus, the relationships may be mediated mainly by variations in severity of frontal pathology among patients.
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