본문 바로가기
KERD
논문KCI 등재

알츠하이머병에서 초조/공격성과 신경해부학적 영역의 연관성

Neuroanatomical Correlation of Agitation/Aggression in Alzheimer’s Disease

2

조회

0

다운로드

0

인용

0

참고문헌

키워드

초록

Objectives:The aim of this study is to identify the association between agitation/aggression and atrophy in specific brain areas in Alzheimer’s disease (AD). Methods:Fifty six patients with mild or moderate AD participated in this study. Cognitive function was measured using the Korean version of the Mini-Mental State Examination (K-MMSE), and Clinical Dementia Rating (CDR). Agitation/aggression symptoms were measured using the Korean version of the Neuropsychiatric Inventory (K-NPI). Atrophies of brain were analyzed using Voxel Based Morphometry (VBM). Results:Higher scores of agitation/aggression were correlated with the atrophy of left middle temporal, left fusiform, right mid- dle temporal, left inferior temporal, right inferior temporal, left superior temporal, left middle occipital, right orbitofrontal, right su- perior frontal, left angular and right middle frontal gyrus (p<0.001, uncorrected for multiple comparisons, extent threshold=200 voxel). Conclusion:Agitation/aggression was correlated with specific neuroanatomical changes in mild or moderate AD.

Abstract

Objectives:The aim of this study is to identify the association between agitation/aggression and atrophy in specific brain areas in Alzheimer’s disease (AD). Methods:Fifty six patients with mild or moderate AD participated in this study. Cognitive function was measured using the Korean version of the Mini-Mental State Examination (K-MMSE), and Clinical Dementia Rating (CDR). Agitation/aggression symptoms were measured using the Korean version of the Neuropsychiatric Inventory (K-NPI). Atrophies of brain were analyzed using Voxel Based Morphometry (VBM). Results:Higher scores of agitation/aggression were correlated with the atrophy of left middle temporal, left fusiform, right mid- dle temporal, left inferior temporal, right inferior temporal, left superior temporal, left middle occipital, right orbitofrontal, right su- perior frontal, left angular and right middle frontal gyrus (p<0.001, uncorrected for multiple comparisons, extent threshold=200 voxel). Conclusion:Agitation/aggression was correlated with specific neuroanatomical changes in mild or moderate AD.

참고문헌 (32)

  1. Stern Y, "Predictors of disease course in patients with probable Alzheimer’s disease", Neurology, 37, pp.1649~1653 (1987)
  2. Mortimer JA, "Predictors of cognitive and functional progression in patients with probable Alzheimer’s disease", Neurology, 42, pp.1689~1696 (1992)
  3. Lopez OL, "Alzheimer’s disease with delusions and hallucinations: neuropsychological and electroencephalographic correlates", Neurology, 41, pp.906~912 (1991)
  4. Finkel SI, "Behavioral and psychological signs and symptoms of dementia: a consensus statement on current knowledge and implications for research and treatment", Int Psychogeriatr, 8(Suppl 3:), pp.497~500 (1996)
  5. Steinberg M, "The persistence of neuropsychiatric symptoms in dementia: the Cache County Study", Int J Geriatr Psychiatry, 19, pp.19~26 (2004)
  6. Kaufer DI, "Assessing the impact of neuropsychiatric symptoms in Alzheimer’s disease: the Neuropsychiatric Inventory Caregiver Distress Scale", J Am Geriatr Soc, 46, pp.210~215 (1998)
  7. Uhde WH, "Psychological disorders and behavioral symp-toms in dementia and differential diagnostic significance", Praxis (Bern 1994), 89, pp.1366~1370 (2000)
  8. Aarsland D, "Relationship of aggressive behavior to other neuropsychiatric symptoms in patients with Alzheimer’s disease", Am J Psychiatry, 153, pp.243~247 (1996)
  9. Chemerinski E, "Prevalence and correlates of aggressive behavior in Alz-heimer’s disease", J Neuropsychiatry Clin Neurosci, 10, pp.421~425 (1998)
  10. Nagaratnam N, "Behavioral and psychiatric manifestations in dementia patients in a community: ca-regiver burden and outcome", Alzheimer Dis Assoc Disord, 12, pp.330~334 (1998)
  11. Rabins PV, "The impact of dementia on the fam ily", JAMA, 248, pp.333~335 (1982)
  12. Victoroff J, "Psychiatric complications of dementia: impact on caregivers", Dement Geriatr Cogn Disord, 9, pp.50~55 (1998)
  13. Hébert R, "Efficacy of a psychoeducative group program for caregivers of demented persons living at home: a randomized controlled trial", J Gerontol B Psychol Sci Soc Sci, 58, pp.S58~S67 (2003)
  14. Knopman DS, "Nursing home placement is related to dementia progression: experience from a clinical trial. Alzheimer’s Disease Cooperative Study", Neurology, 52, pp.714~718 (1999)
  15. Levy ML, "Longitudinal assessment of symptoms of depression, agitation, and psychosis in 181 patients with Alzheimer’s disease", Am J Psychiatry, 153, pp.1438~1443 (1996)
  16. Rosen HJ, "Neuroanatomical correlates of behavioural disorders in dementia", Brain, 128(11), pp.2612~2625 (2005)
  17. Bruen PD, "Neuroanatomical correlates of neuropsychiatric symptoms in Alzheimer’s disease", Brain, 131(9), pp.2455~2463 (2008)
  18. McKhann G, "Clinical diagnosis of Alzheimer’s disease: report of the NINCDS- ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease", Neurology, 34, pp.939~944 (1984)
  19. 강연욱, "K-MMSE(Korean-Mini Mental State Examination)의 노인 규준 연구", 한국심리학회지:일반, 25(2), pp.1~12 (2006), 한국심리학회
  20. Morris JC, "The Clinical Dementia Rating (CDR): current version and scoring rules", Neurology, 43, pp.2412~2414 (1993)
  21. Choi SH, "The Korean version of the neuropsychiatric inventory: a scoring tool for neuropsychiatric disturbance in dementia patients", J Korean Med Sci, 15, pp.609~615 (2000)
  22. Sultzer DL, "The relationship between psychiatric symptoms and regional cortical metabolism in Alzheimer’s disease", J Neuropsychiatry Clin Neurosci, 7, pp.476~484 (1995)
  23. Hirono N, "Left frontotemporal hypoperfusion is associated with aggression in patients with dementia", Arch Neurol, 57, pp.861~866 (2000)
  24. Tekin S, "Orbitofrontal and anterior cingulate cortex neurofibrillary tangle burden is associated with agitation in Alzheimer disease", Ann Neurol, 49, pp.355~361 (2001)
  25. Senanarong V, "Agitation in Alzheimer’s disease is a manifestation of frontal lobe dysfunction", Dement Geriatr Cogn Disord, 17, pp.14~20 (2004)
  26. Brower MC, "Neuropsychiatry of frontal lobe dysfunction in violent and criminal behaviour: a critical review", J Neurol Neurosurg Psychiatry, 71, pp.720~726 (2001)
  27. Beraha E, "Hemispheric asymmetry for affective stimulus processing in healthy subjects--a fMRI study", PLoS One, 7, pp.e46931~ (2012)
  28. Raine A, "Reduced prefrontal and increased subcortical brain functioning assessed using positron emission tomography in predatory and affective murderers", Behav Sci Law, 16, pp.319~332 (1998)
  29. van Elst LT, "Affective aggression in patients with temporal lobe epilepsy: a quantitative MRI study of the amygdala", Brain, 123(2), pp.234~243 (2000)
  30. Raine A, "Brain abnormalities in murderers indicated by positron emission tomography", Biol Psychiatry, 42, pp.495~508 (1997)
  31. Botez SA, "Aggressive behavior and posterior cerebral artery stroke", Arch Neurol, 64, pp.1029~1033 (2007)
  32. Deutsch LH, "Psychosis and physical aggression in probable Alzheimer’s disease", Am J Psychiatry, 148, pp.1159~1163 (1991)

관련 논문AI추천

이 간행물의 다른 논문 (6건)