본문 바로가기
KERD
논문KCI 등재

양극성 장애 환자에서 나타나는 식욕 및 섭식 행동의 특성 : 일반적 음식갈망-특질척도(G-FCQ-T)와 약물 관련 섭식행동 설문지(DR-EBQ)를 이용한 평가

Changes of Appetite and Eating Behavior in Bipolar Disorder Patients : Measurement with General-Food Craving Questionnaire-Trait and the Drug-Related Eating Behavior Questionnaire

2

조회

0

다운로드

3

인용

0

참고문헌

주제분류정신과학

초록

Objectives : In the current study, we quantitatively estimated changes in appetite and eating behavior of bipolar disorder patients during the pharmacotherapy. We also investigated their contribution to the weight gain and their association with specific food-craving characteristics of the patients. Methods : Subjects included forty-one bipolar disorder patients and fifty-six controls. Currently sustained natures of food craving were assessed using the General-Food Craving Questionnaire-Trait (G-FCQ-T) and changes in appetite and eating behavior were measured using the Drug-Related Eating Behavior Questionnaire (DR-EBQ). Results : Compared to the control group, the patients’ group showed significantly higher body mass index (t=2.028, p=0.045). The patients’ group had significantly higher ‘Preoccupation with food’ factor score of G-FCQ-T (p=0.016) than that of the control group. Hierarchical multiple regression analysis showed that only ‘preoccupation with food’ factor independently predicted psychotropic medication-induced appetite change. Conclusions : Appetite change while receiving psychotropic medication seems to be related to the weight-gain and associated with craving natures of ‘preoccupation with food’ in bipolar disorder. Appetite and/or eating behavioral changes measured by G-FCQ-T and DR-EBQ could be regarded as an important mediating factor in future studies exploring biological mechanisms of weight gain related with pharmacotherapy for bipolar disorder.

Abstract

Objectives : In the current study, we quantitatively estimated changes in appetite and eating behavior of bipolar disorder patients during the pharmacotherapy. We also investigated their contribution to the weight gain and their association with specific food-craving characteristics of the patients. Methods : Subjects included forty-one bipolar disorder patients and fifty-six controls. Currently sustained natures of food craving were assessed using the General-Food Craving Questionnaire-Trait (G-FCQ-T) and changes in appetite and eating behavior were measured using the Drug-Related Eating Behavior Questionnaire (DR-EBQ). Results : Compared to the control group, the patients’ group showed significantly higher body mass index (t=2.028, p=0.045). The patients’ group had significantly higher ‘Preoccupation with food’ factor score of G-FCQ-T (p=0.016) than that of the control group. Hierarchical multiple regression analysis showed that only ‘preoccupation with food’ factor independently predicted psychotropic medication-induced appetite change. Conclusions : Appetite change while receiving psychotropic medication seems to be related to the weight-gain and associated with craving natures of ‘preoccupation with food’ in bipolar disorder. Appetite and/or eating behavioral changes measured by G-FCQ-T and DR-EBQ could be regarded as an important mediating factor in future studies exploring biological mechanisms of weight gain related with pharmacotherapy for bipolar disorder.

참고문헌 (50)

  1. Allison DB, "The distribution of body mass index among individuals with and without schizophrenia", J Clin Psychiatry, 60, pp.215~220 (1999)
  2. Elmslie JL, "Prevalence of overweight and obesity in bipolar patients", J Clin Psychiatry, 61, pp.179~184 (2000)
  3. Smith DE, "Prevalence of binge eating disorder, obesity, and depression in a biracial cohort of young adults", Ann Behav Med, 20, pp.227~232 (1998)
  4. Gilmore J, "Body mass index and health", Health Rep, 11, pp.31~47 (1999)
  5. Japanese Ministry of health, "Labour and Welfare", Health and nutrition survey in 2003, ~ (2003)
  6. Fagiolini A, "Prevalence of obesity and weight change during treatment in patients with bipolar I disorder", J Clin Psychiatry, 63, pp.528~533 (2002)
  7. McElroy SL, "Are mood disorders and obesity related? A review for the mental health professional", J Clin Psychiatry, 65, pp.634~651 (2004)
  8. Elmslie JL, "Determinants of overweight and obesity in patients with bipolar disorder", J Clin Psychiatry, 62, pp.486~491 (2001)
  9. Fagiolini A, "Metabolic syndrome in bipolar disorder: findings from the Bipolar Disorder Center for Pennsylvanians", Bipolar Disord, 7, pp.424~430 (2005)
  10. Bernstein JG, "Induction of obesity by psychotropic drugs", Ann N Y Acad Sci, 499, pp.203~215 (1987)
  11. Ruetsch O, "Psychotropic drugs induced weight gain: a review of the literature concerning epidemiological data, mechanisms and management", Encephale, 31, pp.507~516 (2005)
  12. Sachs GS, "Weight gain associated with use of psychotropic medications", J Clin Psychiatry, 60(21), pp.16~19 (1999)
  13. Correll CU, "Pharmacogenetics of antipsychotic-induced weight gain", Psychopharmacology, 174, pp.477~489 (2004)
  14. Wirshing DA, "Schizophrenia and obesity: impact of antipsychotic medications", J Clin Psychiatry, 65(18), pp.13~26 (2004)
  15. Frye MA, "The increasing use of polypharmacotherapy for refractory mood disorders: 22 years of study", J Clin Psychiatry, 61, pp.9~15 (2000)
  16. Guille C, "A naturalistic comparison of clozapine, risperidone, and olanzapine in the treatment of bipolar disorder", J Clin Psychiatry, 61, pp.638~642 (2000)
  17. American Psychiatric Association, "Practice guideline for the treatment of patients with bipolar disorder (revision)", Am J Psychiatry, 159, pp.1~50 (2002)
  18. Bowden CL, "Atypical antipsychotic augmentation of mood stabilizer therapy in bipolar disorder", J Clin Psychiatry, 66(3), pp.12~19 (2005)
  19. Biton V, "Effect of antiepileptic drugs on bodyweight: overview and clinical implications for the treatment of epilepsy", CNS Drugs, 17, pp.781~791 (2003)
  20. Corman CL, "Weight gain in epileptic patients during treatment with valproic acid: a retrospective study", Can J Neurol Sci, 24, pp.240~244 (1997)
  21. Freeman MP, "Lithium: clinical considerations in internal medicine", Am J Med, 119, pp.478~481 (2006)
  22. Allison DB, "Annual deaths attributable to obesity in the United States", JAMA, 282, pp.1530~1538 (1999)
  23. Must A, "The disease burden associated with overweight and obesity", JAMA, 282, pp.1523~1529 (1999)
  24. Allison DB, "The impact of weight gain on quality of life among persons with schizophrenia", Psychiatr Serv, 54, pp.565~567 (2003)
  25. Torrent C, "Weight gain in bipolar disorder: pharmacological treatment as a contributing factor", Acta Psychiatr Scand, 118, pp.4~18 (2008)
  26. Devlin MJ, "Obesity: what mental health professionals need to know", Am J Psychiatry, 157, pp.854~866 (2000)
  27. Leadbetter R, "Clozapine-induced weight gain: prevalence and clinical relevance", Am J Psychiatry, 149, pp.68~72 (1992)
  28. Brömel T, "Serum leptin levels increase rapidly after initiation of clozapine therapy", Mol Psychiatry, 3, pp.76~80 (1998)
  29. Costa e Silva JA, "Olanzapine as alternative therapy for patients with haloperidol-induced extrapyramidal symptoms: results of a multi center, collaborative trial in Latin America", J Clin Psychopharmacol, 21, pp.375~381 (2001)
  30. Theisen FM, "Spectrum of binge eating symptomatology in patients treated with clozapine and olanzapine", J Neural Transm, 110, pp.111~121 (2003)
  31. El-Khatib F, "Valproate, weight gain and carbohydrate craving: a gender study", Seizure, 16, pp.226~232 (2007)
  32. Atmaca M, "Weight gain and serum leptin levels in patients on lithium treatment", Neuropsychobiology, 46, pp.67~69 (2002)
  33. Lim M, "Development and validation of drug-related eating behavior Questionnaire in patients receiving antipsychotic medication", Korean J Schizophr Res, 11, pp.39~44 (2008)
  34. 노지혜, "일반적 음식갈망-특질 척도(G-FCQ-T)의 타당화", 한국심리학회지 임상, 27(4), pp.1039~1051 (2008), 한국임상심리학회
  35. Robinson RG, "Measurement of appetite disturbances in psychiatric disorders", J Psychiatr Res, 12, pp.59~68 (1975)
  36. Godleski LS, "Switching from depot antipsychotic drugs to olanzapine in patients with chronic schizophrenia", J Clin Psychiatry, 64, pp.119~122 (2003)
  37. Poyurovsky M, "Attenuating effect of reboxetine on appetite and weight gain in olanzapine-treated schizophrenia patients: a double-blind placebo- controlled study", Psychopharmacology, 192, pp.441~448 (2007)
  38. Sentissi O, "Impact of antipsychotic treatments on the motivation to eat: preliminary results in 153 schizophrenic patients", Int Clin Psychopharmacol, 24, pp.257~264 (2009)
  39. Blouin M, "Adiposity and eating behaviors in patients under second generation antipsychotics", Obesity, 16, pp.1780~1787 (2008)
  40. Knolle-Veentjer S, "Delay of gratification and executive performance in individuals with schizophrenia: putative role for eating behavior and body weight regulation", J Psychiatr Res, 42, pp.98~105 (2008)
  41. Nijs IM, "The modified Trait and State Food- Cravings Questionnaires: development and validation of a general index of food craving", Appetite, 49, pp.38~46 (2007)
  42. Bowden CL, "A randomized, placebo-controlled 12-month trial of divalproex and lithium in treatment of outpatients with bipolar I disorder. Divalproex Maintenance Study Group", Arch Gen Psychiatry, 57, pp.481~489 (2000)
  43. Tohen M, "Efficacy of olanzapine in combination with valproate or lithium in the treatment of mania in patients partially nonresponsive to valproate or lithium monotherapy", Arch Gen Psychiatry, 59, pp.62~69 (2002)
  44. Ryu S, "Atypical Antipsychotics- Induced Changes of Eating-Behavior in Patients with Schizophrenia Measured by the Drug-Related Eating Behavior Questionnaire (on submission)", ~
  45. Baptista T, "Pharmacological management of atypical antipsychotic- induced weight gain", CNS Drugs, 22, pp.477~495 (2008)
  46. McIntyre RS, "Mechanisms of antipsychotic- induced weight gain", J Clin Psychiatry, 62(23), pp.23~29 (2001)
  47. Nasrallah HA, "Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles", Mol Psychiatry, 13, pp.27~35 (2008)
  48. Elman I, "Food intake and reward mechanisms in patients with schizophrenia: implications for metabolic disturbances and treatment with second-generation antipsychotic agents", Neuropsychopharmacology, 31, pp.2091~2120 (2006)
  49. Garland EJ, "Weight gain with antidepressants and lithium", J Clin Psychopharmacol, 8, pp.323~330 (1988)
  50. Keck PE, "Bipolar disorder, obesity, and pharmacotherapy- associated weight gain", J Clin Psychiatry, 64, pp.1426~1435 (2003)

관련 논문AI추천

이 간행물의 다른 논문 (13건)