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알코올 금단과 혈중 아질산염 농도

Alcohol Withdrawal and Serum Nitrite Concentration

손현균|최인근|이병철
대한생물정신의학회 (The Korean Society Of Biological Psychiatry)|2004.06|생물정신의학 (Journal of Korean Society of Biological Psychiatry)|제11권 제1호|pp. 33-39

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참고문헌

키워드

알코올 의존·산화 질소·아질산염·알코올 금단·음주.Alcohol dependence·Nitric oxide(NO)·Nitrite·Alcohol withdrawal·Alcohol drinking.
주제분류정신과학

초록

Abstract

Nitric oxide(NO) has been known to be associated with tolerance and preference to alcohol. It has also been known to affect various alcohol drinking behavior, alcohol withdrawal symptoms and alcohol- induced brain damage. The purpose of this study was to determine the difference, among alcohol dependence group, alcohol drinking group and abstinence group, in serum concentration of nitrite, a stable metabolite of NO, and it's relationship to clinical and biochemical markers of alcoholism. Methods：Forty subjects diagnosed as alcohol dependence according to DSM-IV diagnostic criteria were evaluated for the clinical characteristics and biochemical markers of alcohol dependence including nitrite with their CIWA-Ar scores checked just after admission. Thirty-nine healthy controls were also evaluated, divided into twenty-three alcohol drinking group and sixteen abstinence group. Clinical characteristics were evaluated by CIWA-Ar, CAGE and AUDIT questionnaires. Aspartate aminotransferase(AST), alanine aminotransferase (ALT), gamma glutamyltransferase(GGT) and mean corpuscular volume(MCV) were used as the biochemical markers of alcohol dependence. Serum nitrite concentrations were measured by Griess reaction. Results：1) The concentrations of nitrite in alcohol dependence patients were not different from those in the control subjects. 2) There were no significant association between the nitrite concentrations and the CIWAAr scores in alcohol dependence patients. 3) Nitrites are significantly increased in alcohol dependence group and alcohol drinking group compared with abstinence group. Conclusions：These findings suggest that serum nitrite concentration has no relation with alcohol withdrawal symptoms, but alcohol drinking increases serum nitrite concentration influenced by general condition of the body.

참고문헌 (32)

  1. "Nitric oxide synthase isoenzymes.characterization, purification, molecular cloningand functions", pp.1121~1131
  2. "Localization of nitricoxide synthase indication a neural role for nitric oxide", pp.768~770
  3. "Nitric oxide: pathophysiologicalmechanims", 57, pp.737~769 (1995)
  4. "A requirement for the intercellularmessanger nitric oxide in long-term potentiation", pp.1503~1506
  5. "Increased striataldopamine efflux in vivo following inhibition of cerebralnitric oxide synthase by the novel monosodium saltof 7-nitro indazole", 114, pp.257~258 (1995)
  6. "Mediationby nitric oxide of the stimulatory effects of ethanolon blood flow", 70, pp.2987~2995 (2002)
  7. "Regulation of neuronal nitric oxide synthase by chronicethanol ingestion", 21, pp.93~95 (1995), .
  8. "Pathogenesis of arterial hypotensionin cirrhotic rats with ascites: role of endogenousnitric oxide", pp.343~349
  9. "Nitricoxide production by mononuclear leukocytes in alcoholiccirrhosis", 73, pp.31~33 (1995)
  10. "Nitric oxide is not increased inalcoholic brain", 32, pp.551~553 (1997)
  11. "알코올 의존 환자에서 혈청 nitrite 농도와임상적 생화학적 상태와의 관련성 한림대학교 대학원 의학과 석사학위 논문" (1999)
  12. ".Nitric oxide-related agents alter alcohol withdrawal inmale rats.", 19, pp.195~199 (1995)
  13. "Inhibition of nitric oxide synthesis impairs rapid toleranceto alcohol", pp.43~47
  14. "Effectsof nitric oxide-related agents on alcohol narcosis", pp.969~975
  15. "Nitric oxide synthesisand metabolism in man", pp.158~164
  16. "Diagnostic and statisticalmanual of mental disorders", pp.175~196
  17. "validation of a new alcoholism screening instrument", pp.1121~1123
  18. "The Alcohol UseDisorders Identification Test(AUDIT) validation of ascreening instrument for use in medical settings", 56, pp.423~432 (1995)
  19. "Assessment of alcohol withdrawal the revisedclinical institute withdrawal assessment for alcoholscale(CIWA-Ar).", pp.1353~1357, CIWA-Ar
  20. "Determination of nitrite", nitrate inhuman biological material by the simple Griess reaction, 1998, pp.274, 177~118
  21. "Increasednitric oxide synthesis and inducible nitric oxidesynthase expression in patients with alcoholic and nonalcoholicliver cirrhosis", 94, pp.637~643 (1998)
  22. "Nitric oxide production by monocytesin alcoholic liver disease", pp.146~150
  23. "Blockade of the L-arginine", NO synthasepathway worsens hepatic apoptosis and liver transplantpreservation injury, 2002, pp.36, 573~581
  24. "Acute alcoholintoxication decreases cell proliferation and nitric oxidesynthase expression in dentate gyrus of rats", 21, pp.255~262 (2002)
  25. "Ethanoleffects on nitric oxide production in cerebral pial cultures", 25, pp.612~618 (2001)
  26. "Effect ofchronic ethanol feeding on nitric oxide synthesis by ratKupffer cells", 20, pp.69~72 (1996)
  27. "Long-term alcohol exposurechanges sensitivity of rat Kupffer cells to lipopolysaccharide", 25, pp.1360~1367 (2001)
  28. "Cytokines, nitric oxidesynthesis and liver regeneration.", 10, pp.12~17
  29. "Ethanolpotentiates interleukin-1 beta-stimulated inducible nitricoxide synthase expression in cultured vascular smoothmuscle cells", 15, pp.231~236 (1995)
  30. "Alcohol and nitric oxide production by cellsof the brain", 16, pp.159~165 (1998)
  31. "Thepotential mechanism of induction of inducible nitric oxidesynthase mRNA in alveolar macrophages by lipopolysaccharideand its suppression by ethanol in vivo", 22, pp.260~265 (1998)
  32. "Ethanol exposureinduces oxidative stress and impairs nitric oxide availabilityin the human placental villi: a possible mechanismof toxicity", 182, pp.682~688

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