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정신장애의 진화유전학적 모델

Evolutionary Genetic Models of Mental Disorders

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주제분류정신과학

초록

Psychiatric disorder as dysfunctional behavioural syndrome is a paradoxical phenomenon that is difficult to explain evolutionarily because moderate prevalence rate, high heritability and relatively low fitness are shown. Several evolutionary genetic models have been proposed to address this paradox. In this paper, I explain each model by dividing it into selective neutrality, mutation-selection balance, and balancing selection hypothesis, and discuss the advantages and disadvantages of them. In addition, the feasibility of niche specialization and frequency dependent selection as the plausible explanation about the central paradox is briefly discussed.

Abstract

Psychiatric disorder as dysfunctional behavioural syndrome is a paradoxical phenomenon that is difficult to explain evolutionarily because moderate prevalence rate, high heritability and relatively low fitness are shown. Several evolutionary genetic models have been proposed to address this paradox. In this paper, I explain each model by dividing it into selective neutrality, mutation-selection balance, and balancing selection hypothesis, and discuss the advantages and disadvantages of them. In addition, the feasibility of niche specialization and frequency dependent selection as the plausible explanation about the central paradox is briefly discussed.

참고문헌 (52)

  1. Hunt J, "Evolutionary Behavioral Ecology", pp.46~70 (2010), Oxford University Press
  2. The World Health Report 2001: Mental health: New Understanding, New Hope, "WHO", World Health Organization, ~ (2001)
  3. Kessler RC, "Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication", Arch Gen Psychiatry, 62, pp.593~602 (2005)
  4. Wittchen HU, "The size and burden of mental disorders and other disorders of the brain in Europe 2010", Eur Neuropsychopharmacol, 21, pp.655~679 (2011)
  5. Smoller JW, "Panic and phobic anxiety : defining phenotypes for genetic studies", Am J Psychiatry, 155, pp.1152~1162 (1998)
  6. Mäki P, "Predictors of schizophrenia--a review", Br Med Bull, 73-74, pp.1~15 (2005)
  7. Uher R, "The role of genetic variation in the causation of mental illness : an evolution-informed framework", Mol Psychiatry, 14, pp.1072~1082 (2009)
  8. Cross-Disorder Group of the Psychiatric Genomics Consortium, "Erratum : Identification of risk loci with shared effects on five major psychiatric disorders : a genome-wide analysis", Lancet, 381, pp.1371~1379 (2013)
  9. Hettema JM, "The structure of genetic and environmental risk factors for anxiety disorders in men and women", Arch Gen Psychiatry, 62, pp.182~189 (2005)
  10. Keller MC, "Resolving the paradox of common, harmful, heritable mental disorders: which evolutionary genetic models work best?", Behav Brain Sci, 29, pp.385~404 (2006)
  11. Risch N, "The future of genetic studies of complex human diseases", Science, 273, pp.1516~1517 (1996)
  12. Lander ES, "The new genomics : global views of biology", Science, 274, pp.536~539 (1996)
  13. 박한선, "정신의학의 진화적 접근", 신경정신의학, 53(6), pp.347~357 (2014), 대한신경정신의학회[DOI]
  14. Cartwright J., "Evolution and Human Behaviour: Darwinian Perspectives on the Human Condition" (2016), Palgrave
  15. Huxley J, "Schizophrenia as a genetic morphism", Nature, 204, pp.220~221 (1964)
  16. Herron JC, "Evolutionary Analysis" (2014), Pearson
  17. Estrada-Mena B, "Blood group O alleles in Native Americans : implications in the peopling of the Americas", Am J Phys Anthropol, 142, pp.85~94 (2010)
  18. Lynch M, "Phenotypic evolution by neutral mutation", Evolution, 40, pp.915~935 (1986)
  19. Cargill M, "Characterization of single-nucleotide polymorphisms in coding regions of human genes", Nat Genet, 22, pp.231~238 (1999)
  20. Merilä J, "Genetic architecture of fitness and nonfitness traits : empirical patterns and development of ideas", Heredity(Edinb), 83, pp.103~109 (1999)
  21. Crnokrak P, "Dominance variance : associations with selection and fitness", Heredity, 75, pp.530~540 (1995)
  22. Eaves LJ, "Sex differences and non-additivity in the effects of genes on personality", Twin Res, 1, pp.131~137 (1998)
  23. Keller MC, "Widespread evidence for non-additive genetic variation in Cloninger’s and Eysenck’s personality dimensions using a twin plus sibling design", Behav Genet, 35, pp.707~721 (2005)
  24. Bouchard TJ Jr, "Sources of human psychological differences : the Minnesota study of twins reared apart", Science, 250, pp.223~228 (1990)
  25. Eaves L, "Comparing the biological and cultural inheritance of personality and social attitudes in the Virginia 30,000 study of twins and their relatives", Twin Res, 2, pp.62~80 (1999)
  26. Penke L, "The evolutionary genetics of personality", Eur J Pers, 21, pp.549~587 (2007)
  27. Keightley PD, "Functional constraints and frequency of deleterious mutations in noncoding DNA of rodents", Proc Natl Acad Sci U S A, 100, pp.13402~13406 (2003)
  28. Eyre-Walker A, "High genomic deleterious mutation rates in hominids", Nature, 397, pp.344~347 (1999)
  29. Stirling D, "Selection, structure and the heritability of behaviour", J Evol Biol, 15, pp.277~289 (2002)
  30. Hughes KA, "Genetic Influences on Human Fertility and Sexuality:Theoretical and Empirical Contributions from the Biological and Behavioral Sciences", pp.7~33 (2000), Kluwer Academin Publishers
  31. Houle D, "Comparing evolvability and variability of quantitative traits", Genetics, 130, pp.195~204 (1992)
  32. Cannon TD, "Endophenotypes in the genetic analyses of mental disorders", Annu Rev Clin Psychol, 2, pp.267~290 (2006)
  33. Lykken DT, "Is human mating adventitious or the result of lawful choice? A twin study of mate selection", J Pers Soc Psychol, 65, pp.56~68 (1993)
  34. Figueredo AJ, "The ideal romantic partner personality", Pers Individ Dif, 41, pp.431~441 (2006)
  35. Bergmüller R, "Adaptive behavioural syndromes due to strategic niche specialization", BMC Ecol, 7, pp.12~ (2007)
  36. Roff DA, "Evolutionary Quantitative Genetics" (1997), Chapman & Hall
  37. Turelli M, "Polygenic variation maintained by balancing selection: pleiotropy, sex-dependent allelic effects and G x E interactions", Genetics, 166, pp.1053~1079 (2004)
  38. Sulloway FJ., "Born to Rebel: Birth Order, Family Dynamics, and Creative Lives" (1996), Pantheon Books
  39. Tooby J, "On the universality of human nature and the uniqueness of the individual : the role of genetics and adaptation", J Pers, 58, pp.17~67 (1990)
  40. Bond AB, "Apostatic selection by blue jays produces balanced polymorphism in virtual prey", Nature, 395, pp.594~596 (1998)
  41. McGrath J, "Schizophrenia: a concise overview of incidence, prevalence, and mortality", Epidemiol Rev, 30, pp.67~76 (2008)
  42. Moreira ALR, "Review and meta-analysis of epidemiologic studies of adult bipolar disorder", J Clin Psychiatry, 78, pp.e1259~e1269 (2017)
  43. Manolio TA, "Genomewide association studies and assessment of the risk of disease", N Engl J Med, 363, pp.166~176 (2010)
  44. Ng MY, "Meta-analysis of 32 genome-wide linkage studies of schizophrenia", Mol Psychiatry, 14, pp.774~785 (2009)
  45. International Schizophrenia Consortium, "Common polygenic variation contributes to risk of schizophrenia and bipolar disorder", Nature, 460, pp.748~752 (2009)
  46. Wang KS, "A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder", Schizophr Res, 124, pp.192~199 (2010)
  47. Schizophrenia Psychiatric Genome-Wide Association Study(GWAS)Consortium, "Genome-wide association study identifies five new schizophrenia loci", Nat Genet, 43, pp.969~976 (2011)
  48. Sullivan PF, "Genetic architectures of psychiatric disorders : the emerging picture and its implications", Nat Rev Genet, 13, pp.537~551 (2012)
  49. International Schizophrenia Consortium, "Rare chromosomal deletions and duplications increase risk of schizophrenia", Nature, 455, pp.237~241 (2008)
  50. Sullivan PF, "Schizophrenia as a complex trait : evidence from a meta-analysis of twin studies", Arch Gen Psychiatry, 60, pp.1187~1192 (2003)
  51. Drent PJ, "Contribution of genetics to the study of animal personalities : a review of case studies", Behaviour, 142, pp.1185~1206 (2005)
  52. Nettle D, "The evolution of personality variation in humans and other animals", Am Psychol, 61, pp.622~631 (2006)

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