본문 바로가기
KERD
논문KCI 등재

Effects of adjunctive daily phototherapy on chronic periodontitis: a randomized single-blind controlled trial

2

조회

0

다운로드

0

인용

0

참고문헌

키워드

주제분류치의학

초록

Purpose: The purpose of this randomized single-blind controlled trial was to elucidate theclinical and antimicrobial effects of daily phototherapy (PT) as an adjunct to scaling androot planing (SRP) in patients with chronic periodontitis. Methods: The study was conducted from December 2013 to May 2014 at Ewha WomansUniversity Mokdong Hospital, Seoul, Korea. Forty-one patients with mild to moderatechronic periodontitis were randomly divided into two therapeutic groups in a 1:1 ratio:SRP+PT and SRP (control) groups. All participants underwent full-mouth SRP. PT was performedthrice a day for a month by using electric toothbrushes with embedded light-emittingdiodes. Plaque index, gingival index, probing pocket depth (PPD), clinical attachmentlevel (CAL), and bleeding on probing were assessed before (baseline) and four weeks after(follow-up) the treatment. Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis,Tannerella forsythia, Treponema denticola, Prevotella intermedia, Fusobacteriumnucleatum, Parvimonas micra, Campylobacter rectus, Eikenella corrodens, Streptococcusmutans, and Streptococcus sobrinus levels were detected by a real-time polymerase chainreaction at the same points in time. Results: The clinical parameters improved in both the groups. At the follow-up assessment,PPD was significantly decreased in the SRP+PT group (P=0.00). Further, PPD and CALshowed significantly greater changes in the SRP+PT group than in the SRP group (PPD,P=0.03; CAL, P=0.04). P. gingivalis and T. forsythia levels decreased in this group, but nosignificant intergroup differences were noted. Conclusions: Adjunctive PT seems to have clinical benefits, but evidence of its antimicrobialeffects is not sufficient. Long-term studies are necessary to develop the most effective PTprotocol and compare the effectiveness of PT with and without exogenous photosensitizers.

Abstract

Purpose: The purpose of this randomized single-blind controlled trial was to elucidate theclinical and antimicrobial effects of daily phototherapy (PT) as an adjunct to scaling androot planing (SRP) in patients with chronic periodontitis. Methods: The study was conducted from December 2013 to May 2014 at Ewha WomansUniversity Mokdong Hospital, Seoul, Korea. Forty-one patients with mild to moderatechronic periodontitis were randomly divided into two therapeutic groups in a 1:1 ratio:SRP+PT and SRP (control) groups. All participants underwent full-mouth SRP. PT was performedthrice a day for a month by using electric toothbrushes with embedded light-emittingdiodes. Plaque index, gingival index, probing pocket depth (PPD), clinical attachmentlevel (CAL), and bleeding on probing were assessed before (baseline) and four weeks after(follow-up) the treatment. Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis,Tannerella forsythia, Treponema denticola, Prevotella intermedia, Fusobacteriumnucleatum, Parvimonas micra, Campylobacter rectus, Eikenella corrodens, Streptococcusmutans, and Streptococcus sobrinus levels were detected by a real-time polymerase chainreaction at the same points in time. Results: The clinical parameters improved in both the groups. At the follow-up assessment,PPD was significantly decreased in the SRP+PT group (P=0.00). Further, PPD and CALshowed significantly greater changes in the SRP+PT group than in the SRP group (PPD,P=0.03; CAL, P=0.04). P. gingivalis and T. forsythia levels decreased in this group, but nosignificant intergroup differences were noted. Conclusions: Adjunctive PT seems to have clinical benefits, but evidence of its antimicrobialeffects is not sufficient. Long-term studies are necessary to develop the most effective PTprotocol and compare the effectiveness of PT with and without exogenous photosensitizers.

참고문헌 (35)

  1. Renvert S, "Treatment of periodontal disease based on microbiological diagnosis: relation between microbiological and clinical parameters during 5 years", J Periodontol, 67, pp.562~571 (1996)
  2. Haffajee AD, "Systemic antibiotics: to use or not to use in the treatment of periodontal infections: that is the question", J Clin Periodontol, 33, pp.359~361 (2006)
  3. Darveau RP, "The microbial challenge in periodontitis", Periodontol 2000, 14, pp.12~32 (1997)
  4. Soukos NS, "Photodynamic therapy in the control of oral biofilms", Periodontol 2000, 55, pp.143~166 (2011)
  5. Diamond I, "Jaenicke R. Photodynamic therapy of malignant tumours", Lancet, 2, pp.1175~1177 (1972)
  6. Braun A, "Short-term clinical effects of adjunctive antimicrobial photodynamic therapy in periodontal treatment: a randomized clinical trial", J Clin Periodontol, 35, pp.877~884 (2008)
  7. Ge L, "Adjunctive effect of photodynamic therapy to scaling and root planing in the treatment of chronic periodontitis", Photomed Laser Surg, 29, pp.33~37 (2011)
  8. Sigusch BW, "Efficacy of photodynamic therapy on inflammatory signs and two selected periodontopathogenic species in a beagle dog model", J Periodontol, 76, pp.1100~1105 (2005)
  9. O'Neill JF, "Oral bacteria in multi-species biofilms can be killed by red light in the presence of toluidine blue", Lasers Surg Med, 31, pp.86~90 (2002)
  10. Soukos NS, "Photomechanical drug delivery into bacterial biofilms", Pharm Res, 17, pp.405~409 (2000)
  11. Balata ML, "Photodynamic therapy associated with full-mouth ultrasonic debridement in the treatment of severe chronic periodontitis: a randomized-controlled clinical trial", J Appl Oral Sci, 21, pp.208~214 (2013)
  12. Andersen R, "Treatment of periodontal disease by photodisinfection compared to scaling and root planing", J Clin Dent, 18, pp.34~38 (2007)
  13. Betsy J, "Efficacy of antimicrobial photodynamic therapy in the management of chronic periodontitis: a randomized controlled clinical trial", J Clin Periodontol, 41, pp.573~581 (2014)
  14. Fukui M, "Specific-wavelength visible light irradiation inhibits bacterial growth of Porphyromonas gingivalis", J Periodontal Res, 43, pp.174~178 (2008)
  15. de Almeida JM, "Influence of photodynamic therapy on the development of ligature-induced periodontitis in rats", J Periodontol, 78, pp.566~575 (2007)
  16. Smalley JW, "Interactions of Porphyromonas gingivalis with oxyhaemoglobin and deoxyhaemoglobin", Biochem J, 362(Pt 1), pp.239~245 (2002)
  17. Soukos NS, "Phototargeting oral black-pigmented bacteria", Antimicrob Agents Chemother, 49, pp.1391~1396 (2005)
  18. Silness J, "Periodontal disease in pregnancy. II: correlation between oral hygiene and periodontal condtion", Acta Odontol Scand, 22, pp.121~135 (1964)
  19. Loe H, "The gingival index, the plaque index and the retention index systems", J Periodontol, 38(Suppl), pp.610~616 (1967)
  20. Ainamo J, "Problems and proposals for recording gingivitis and plaque", Int Dent J, 25, pp.229~235 (1975)
  21. de Almeida JM, "Treatment of experimental periodontal disease by photodynamic therapy in rats with diabetes", J Periodontol, 79, pp.2156~2165 (2008)
  22. "Photodynamic therapy as an adjunct to non-surgical periodontal treatment: a randomized, controlled clinical trial", J Periodontol, 79, pp.1638~1644 (2008)
  23. Polansky R, "Clinical effectiveness of photodynamic therapy in the treatment of periodontitis", J Clin Periodontol, 36, pp.575~580 (2009)
  24. Theodoro LH, "Clinical and microbiological effects of photodynamic therapy associated with nonsurgical periodontal treatment. A 6-month follow-up", Lasers Med Sci, 27, pp.687~693 (2012)
  25. Pourabbas R, "Effects of photodynamic therapy on clinical and gingival crevicular fluid inflammatory biomarkers in chronic periodontitis: a split-mouth randomized clinical trial", J Periodontol, 85, pp.1222~1229 (2014)
  26. Bassir SH, "Photoactivated disinfection using light-emitting diode as an adjunct in the management of chronic periodontitis: a pilot double-blind split-mouth randomized clinical trial", J Clin Periodontol, 40, pp.65~72 (2013)
  27. Wainwright M, "Photodynamic therapy: the development of new photosensitisers", Anticancer Agents Med Chem, 8, pp.280~291 (2008)
  28. Robinson DJ, "Fluorescence photobleaching of ALA-induced protoporphyrin IX during photodynamic therapy of normal hairless mouse skin: the effect of light dose and irradiance and the resulting biological effect", Photochem Photobiol, 67, pp.140~149 (1998)
  29. Pfitzner A, "Killing of periodontopathogenic bacteria by photodynamic therapy", J Periodontol, 75, pp.1343~1349 (2004)
  30. Sorkhdini P, "Effect of hydrosoluble chlorine-mediated antimicrobial photodynamic therapy on clinical parameters and cytokine profile in ligature-induced periodontitis in dogs", J Periodontol, 84, pp.793~800 (2013)
  31. Nagahara A, "Antimicrobial photodynamic therapy using a diode laser with a potential new photosensitizer, indocyanine green-loaded nanospheres, may be effective for the clearance of Porphyromonas gingivalis", J Periodontal Res, 48, pp.591~599 (2013)
  32. Minnock A, "Photoinactivation of bacteria. Use of a cationic water-soluble zinc phthalocyanine to photoinactivate both gram-negative and gram-positive bacteria", J Photochem Photobiol B, 32, pp.159~164 (1996)
  33. Soukos NS, "Photodestruction of human dental plaque bacteria: enhancement of the photodynamic effect by photomechanical waves in an oral biofilm model", Lasers Surg Med, 33, pp.161~168 (2003)
  34. Komerik N, "The effect of photodynamic action on two virulence factors of gram-negative bacteria", Photochem Photobiol, 72, pp.676~680 (2000)
  35. Chui C, "Antimicrobial effect of photodynamic therapy using high-power blue light-emitting diode and red-dye agent on Porphyromonas gingivalis", J Periodontal Res, 48, pp.686~705 (2013)

관련 논문AI추천

Adjunctive effect of 470-nm and 630-nm light-emitting diode irradiation in experimental periodontitis treatment: a preclinical study구기태, 설양조, 송우섭, 안선희, 이동섭, 이용무, 이정원, Ling Li대한치주과학회 · Journal of Periodontal & Implant Science2024 · 제54권 제1호광역학요법을 이용한 치주염치료 - 체계적 문헌고찰 및 메타분석모진아대한치과의사협회 · 대한치과의사협회지2016 · 제54권 제6호Repeated irradiation by light-emitting diodes may impede the spontaneous progression of experimental periodontitis: a preclinical study구기태, 서혜미, 설양조, 송우섭, 안선희, 이용무, 이정원, Ling Li대한치주과학회 · Journal of Periodontal & Implant Science2023 · 제53권 제2호Phototoxic effect of blue light on the planktonic and biofilm state of anaerobic periodontal pathogens송현화, 엄흥식, 이민구, 이시영, 이재관, 장범석대한치주과학회 · Journal of Periodontal & Implant Science2013 · 제43권 제2호Efficacy of an LED toothbrush on a Porphyromonas gingivalis biofilm on a sandblasted and acid-etched titanium surface: an in vitro study이재관, Hae Lee, Heung-Sik Um, m-Seok Chang, Si Young Lee, Yong-Gun Kim대한치주과학회 · Journal of Periodontal & Implant Science2018 · 제48권 제3호Immediate effect of Nd:YAG laser monotherapy on subgingival periodontal pathogens: a pilot clinical studyMark N. McCawley, Thomas E. Rams, Thomas K. McCawley대한치주과학회 · Journal of Periodontal & Implant Science2022 · 제52권 제1호

이 간행물의 다른 논문 (6건)