일 대학병원 정신건강의학과 병동에서의 비정형 항정신병제 처방 경향 : 11년 관찰 연구
Prescription Pattern of Atypical Antipsychotics in a University Psychiatric Ward : 11-Year Observational Study
2
조회
0
다운로드
2
인용
0
참고문헌
키워드
초록
Objectives : This study investigated the prescribing patterns of atypical antipsychotics for the various psychiatric disorders in the psychiatric ward of a University hospital. Methods : We reviewed the medical records of patients who were discharged from an open psychiatric ward from May, 2003 through April, 2014. The association between psychiatric disorders and prescription pattern of atypical antipsychotics was analyzed. Results : The study included 3091 patients’ prescription of psychiatric medication. 60% of prescription included antipsychotics; quetiapine was the most frequently prescribed antipsychotics, but the average dosage was the lowest among all the atypical antipsychotics. According to the diagnoses, prescription rates and dosage of antipsychotics were different. Prescription rates of antipsychotics were the lowest in patients with anxiety disorders, and the mean dosage were the lowest in those with delirium, dementia, and amnestic and other cognitive disorders. Conclusion : This observational study shows prescription patterns of atypical antipsychotics for the treatment of psychiatric disorders in a University hospital; atypical antipsychotics were widely used for the treatment of the various disorders, and there were differences in prescription patterns for each disorders. The results of this study may be used to identify the proper atypical antipsychotics effective on certain psychiatric disorders and to propose expanding the indications of each atypical antipsychotics in the future.
Abstract
Objectives : This study investigated the prescribing patterns of atypical antipsychotics for the various psychiatric disorders in the psychiatric ward of a University hospital. Methods : We reviewed the medical records of patients who were discharged from an open psychiatric ward from May, 2003 through April, 2014. The association between psychiatric disorders and prescription pattern of atypical antipsychotics was analyzed. Results : The study included 3091 patients’ prescription of psychiatric medication. 60% of prescription included antipsychotics; quetiapine was the most frequently prescribed antipsychotics, but the average dosage was the lowest among all the atypical antipsychotics. According to the diagnoses, prescription rates and dosage of antipsychotics were different. Prescription rates of antipsychotics were the lowest in patients with anxiety disorders, and the mean dosage were the lowest in those with delirium, dementia, and amnestic and other cognitive disorders. Conclusion : This observational study shows prescription patterns of atypical antipsychotics for the treatment of psychiatric disorders in a University hospital; atypical antipsychotics were widely used for the treatment of the various disorders, and there were differences in prescription patterns for each disorders. The results of this study may be used to identify the proper atypical antipsychotics effective on certain psychiatric disorders and to propose expanding the indications of each atypical antipsychotics in the future.
참고문헌 (40)
- Olfson M, "National trends in the office-based treatment of children, adolescents, and adults with antipsychotics", Archives of General Psychiatry, 69, pp.1247~1256 (2012)
- Crystal S, "Broadened use of atypical antipsychotics: safety, effectiveness, and policy challenges", Health Affairs, 28, pp.w770~w781 (2009)
- Rothbard AB, "Trends in the rate and type of antipsychotic medications prescribed to persons with schizophrenia", Schizophrenia Bulletin, 29, pp.531~540 (2003)
- Diatta T, "Patterns and frequency of atypical antipsychotic prescribing in psychiatric medical centers: a cross-sectional national survey", Fundamental & Clinical Pharmacology, 21, pp.371~378 (2007)
- Kerwin R, "New antipsychotics", CNS Drugs, 6, pp.71~82 (1996)
- Thomas CS, "Which atypical antipsychotic?", British Journal of Psychiatry, 172, pp.9~ (1998)
- Dolder CR, "Antipsychotic medication adherence: is there a difference between typical and atypical agents?", American Journal of Psychiatry, 159, pp.103~108 (2002)
- Maher AR, "Efficacy and comparative effectiveness of atypical antipsychotic medications for off-label uses in adults: a systematic review and meta-analysis", JAMA, 306, pp.1359~1369 (2011)
- Maher AR, "Summary of the comparative effectiveness review on off-label use of atypical antipsychotics", Journal of Managed Care Pharmacy, 18, pp.1~20 (2012)
- 변선정, "정신건강의학과 개방병동 입원 환자의 진단군별 약물 처방 경향 변화 : 경기도 소재 일 대학병원에서의 11년 비교 연구", 생물정신의학, 22(4), pp.195~204 (2015), 대한생물정신의학회
- 권준수, "일 대학병원에서 정신분열병 외래환자의 약물사용 경향", 신경정신의학, 42(6), pp.683~690 (2003), 대한신경정신의학회
- Gardner DM, "International consensus study of antipsychotic dosing", American Journal of Psychiatry, 167, pp.686~693 (2010)
- Bret MC, "The use of atypical antipsychotics in French psychiatric hospitals", Pharmacy World &Science, 29, pp.551~556 (2007)
- Migler BM, "Seroquel: behavioral effects in conventional and novel tests for atypical antipsychotic drug", Psychopharmacology, 112, pp.299~307 (1993)
- McManus DQ, "Quetiapine, a novel antipsychotic: experience in elderly patients with psychotic disorders", The Journal of Clinical Psychiatry, 60, pp.292~298 (1999)
- McDonagh M, "Drug class review: atypical antipsychotic drugs" (2010)
- McEvoy JP, "Efficacy and tolerability of olanzapine, quetiapine, and risperidone in the treatment of early psychosis: a randomized, double-blind 52-week comparison", American Journal of Psychiatry, 164, pp.1050~1060 (2007)
- Miller DD, "Extrapyramidal side-effects of antipsychotics in a randomised trial", Br J Psychiatry, 193, pp.279~288 (2008)
- Keck PE, "Aripiprazole monotherapy in the treatment of acute bipolar I mania: a randomized, double-blind, placebo- and lithium-controlled study", J Affect Disord, 112, pp.36~49 (2009)
- Young AH, "Aripiprazole monotherapy in acute mania: 12-week randomised placebo- and haloperidol-controlled study", Br J Psychiatry, 194, pp.40~48 (2009)
- Scherk H, "Second-generation antipsychotic agents in the treatment of acute mania: a systematic review and meta-analysis of randomized controlled trials", Arch Gen Psychiatry, 64, pp.442~455 (2007)
- Smith LA, "Pharmacological interventions for acute bipolar mania: a systematic review of randomized placebo-controlled trials", Bipolar Disorders, 9, pp.551~560 (2007)
- Krakowski MI, "Atypical antipsychotic agents in the treatment of violent patients with schizophrenia and schizoaffective disorder", Arch Gen Psychiatry, 63, pp.622~629 (2006)
- Volavka J, "Overt Aggression and Psychotic Symptoms in Patients With Schizophrenia Treated With Clozapine, Olanzapine, Risperidone, or Haloperidol", J Clin Psychopharmacol, 24, pp.225~228 (2004)
- Snaterse M, "A retrospective, naturalistic review comparing clinical outcomes of in-hospital treatment with risperidone and olanzapine", Clinical Drug Investigation, 20, pp.159~164 (2000)
- Taylor DM, "Risperidone Olanzapine Drug Outcomes Studies in Schizophrenia UKIG. Risperidone compared with olanzapine in a naturalistic clinical study: a cost analysis", J Clin Psychiatry, 64, pp.589~597 (2003)
- Kasper S, "Risperidone Olanzapine Drug Outcomes studies in Schizophrenia (RODOS): Efficacy and tolerability results of an international naturalistic study", Int Clin Psychopharmacol, 16, pp.179~187 (2001)
- Lucey JV, "Risperidone compared with olanzapine in a naturalistic clinical study in Ireland: a cost analysis", Ir J Med Sci, 172, pp.195~201 (2003)
- Danion JM, "Improvement of schizophrenic patients with primary negative symptoms treated with amisulpride", American Journal of Psychiatry, 156, pp.610~616 (1999)
- Lecrubier Y, "Amisulpride versus imipramine and placebo in dysthymia and major depression", Journal of Affective Disorders, 43, pp.95~103 (1997)
- Lecrubier Y, "Improvement by amisulpride of the negative syndrome in non-psychotic subjects: A preliminary study", Psychiatrie & Psychobiologie, 3, pp.329~333 (1988)
- Maglione M, "Off-label use of atypical antipsychotics: an update" (2011)
- Maher AR, "Summary of the comparative effectiveness review on off-label use of atypical antipsychotics", Journal of Managed Care Pharmacy, pp.18~ (2012)
- Sultzer DL, "Clinical symptom responses to atypical antipsychotic medications in Alzheimer’s disease:phase 1 outcomes from the CATIE-AD effectiveness trial", American Journal of Psychiatry, 165, pp.844~854 (2008)
- Maina G, "8-week, single-blind, randomized trial comparing risperidone versus olanzapine augmentation of serotonin reuptake inhibitors in treatment-resistant obsessive-compulsive disorder", European Neuropsychopharmacology, 18, pp.364~372 (2008)
- Matsunaga H, "A long-term trial of the effectiveness and safety of atypical antipsychotic agents in augmenting SSRI-refractory obsessive-compulsive disorder", The Journal of Clinical Psychiatry, 70, pp.863~868 (2009)
- Rapoport M, "Antipsychotic use in the elderly: shifting trends and increasing costs", International Journal of Geriatric Psychiatry, 20, pp.749~753 (2005)
- Verdoux H, "Antipsychotic prescribing trends: a review of pharmaco-epidemiological studies", Acta Psychiatrica Scandinavica, 121, pp.4~10 (2010)
- Jeste DV, "ACNP White Paper: update on use of antipsychotic drugs in elderly persons with dementia", Neuropsychopharmacology, 33, pp.957~970 (2008)
- Schneider LS, "Risk of death with atypical antipsychotic drug treatment for dementia: meta-analysis of randomized placebo-controlled trials", JAMA, 294, pp.1934~1943 (2005)
