조현병 환자에서 성별에 따른 인지기능의 차이
Gender Differences in Cognitive Function of Schizophrenia Patients
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Objectives: Cognitive impairment is a fundamental symptom of schizophrenia, an often-overlooked aspect of the disorder that has gained recent attention due to its direct relation with functional outcomes and implications for medical and social costs. This study aims to investigate gender differences in cognitive function among patients with schizophrenia using Korean Wechsler Adult Intelligence Scale-IV (K-WAIS-IV). Methods: Data were collected from inpatients and outpatients treated at Presbyterian Medical Center between January 1, 2019, and December 31, 2023. Patients diagnosed with schizophrenia underwent evaluation with the K-WAIS-IV. Multivariate analysis of variance was utilized to assess cognitive differences between men and women participants, while correlation analysis was performed to explore associations between cognitive performance and clinical data. Results: Among 101 candidates, 26 male and 26 female patients were selected for analysis of their K-WAIS-IV scores and clinical data. The results revealed no statistically significant differences in cognitive function between male and female patients concerning Full-Scale Intelligence Quotient (FSIQ) and the four index scores: Verbal Comprehension Index (VCI), Perceptual Reasoning Index (PRI), Working Memory Index (WMI), and Processing Speed Index (PSI). A trend indicating preserved verbal intelligence relative to performance intelligence was observed. Additionally, the VCI exhibited a positive correlation with age, while both FSIQ and PSI demonstrated positive correlations with years of education. Conclusion: The findings of this investigation suggest that there are no significant differences in cognitive function between male and female patients with schizophrenia via K-WAIS-IV. Given the heterogeneity of the sample and potential limitations of the neurocognitive assessments employed, further research utilizing more targeted methodologies and sensitive measures is warranted.
Abstract
Objectives: Cognitive impairment is a fundamental symptom of schizophrenia, an often-overlooked aspect of the disorder that has gained recent attention due to its direct relation with functional outcomes and implications for medical and social costs. This study aims to investigate gender differences in cognitive function among patients with schizophrenia using Korean Wechsler Adult Intelligence Scale-IV (K-WAIS-IV). Methods: Data were collected from inpatients and outpatients treated at Presbyterian Medical Center between January 1, 2019, and December 31, 2023. Patients diagnosed with schizophrenia underwent evaluation with the K-WAIS-IV. Multivariate analysis of variance was utilized to assess cognitive differences between men and women participants, while correlation analysis was performed to explore associations between cognitive performance and clinical data. Results: Among 101 candidates, 26 male and 26 female patients were selected for analysis of their K-WAIS-IV scores and clinical data. The results revealed no statistically significant differences in cognitive function between male and female patients concerning Full-Scale Intelligence Quotient (FSIQ) and the four index scores: Verbal Comprehension Index (VCI), Perceptual Reasoning Index (PRI), Working Memory Index (WMI), and Processing Speed Index (PSI). A trend indicating preserved verbal intelligence relative to performance intelligence was observed. Additionally, the VCI exhibited a positive correlation with age, while both FSIQ and PSI demonstrated positive correlations with years of education. Conclusion: The findings of this investigation suggest that there are no significant differences in cognitive function between male and female patients with schizophrenia via K-WAIS-IV. Given the heterogeneity of the sample and potential limitations of the neurocognitive assessments employed, further research utilizing more targeted methodologies and sensitive measures is warranted.
참고문헌 (31)
- McCutcheon RA, "Cognitive impairment in schizophrenia : aetiology, pathophysiology, and treatment", Mol Psychiatry, 28, pp.1902~1918 (2023)
- Ko H, "The relationship between cognitive function and psychosocial function in chronic schizophrenia patients", Kor J Clin Psychol, 36, pp.10~19 (2017)
- Jeon DW, "A review of pharmacological strategy for cognitive deficits in schizophrenia", Korean J Schizophr Res, 17, pp.55~62 (2014)
- Green MF, "Nonsocial and social cognition in schizophrenia : current evidence and future directions", World Psychiatry, 18, pp.146~161 (2019)
- Green MF, "Stimulating the development of drug treatments to improve cognition in schizophrenia", Annu Rev Clin Psychol, 3, pp.159~180 (2007)
- Green MF, "Approaching a consensus cognitive battery for clinical trials in schizophrenia : the NIMH-MATRICS conference to select cognitive domains and test criteria", Biol Psychiatry, 56, pp.301~307 (2004)
- August SM, "The MATRICS consensus cognitive battery(MCCB) : clinical and cognitive correlates", Schizophr Res, 134, pp.76~82 (2012)
- Jo YT, "Changes in the DSM diagnostic concept of schizophrenia:from 1980 to 2013", J Korean Neuropsychiatr Assoc, 60, pp.241~252 (2021)
- Barch DM, "Logic and justification for dimensional assessment of symptoms and related clinical phenomena in psychosis : relevance to DSM-5", Schizophr Res, 150, pp.15~20 (2013)
- Riecher-Rössler A, "Sex and gender differences in schizophrenic psychoses—a critical review", Arch Womens Ment Health, 21, pp.627~648 (2018)
- Ochoa S, "Gender differences in schizophrenia and first-episode psychosis : a comprehensive literature review", Schizophr Res Treatment, 2012, pp.916198~ (2012)
- Giordano GM, "Gender differences in clinical and psychosocial features among persons with schizophrenia : a mini review", Front Psychiatry, 12, pp.789179~ (2021)
- Michel NM, "WAIS-IV profile of cognition in schizophrenia", Assessment, 20, pp.462~473 (2013)
- Seo L, "KWAIS-IV profile in schizophrenia", Kor J Clin Psychol, 33, pp.719~734 (2014)
- Fuentes-Durá I, "WAIS-IV performance in patients with schizophrenia", J Nerv Ment Dis, 207, pp.467~473 (2019)
- Moon HW, "Intellectual changes in the patients with schizophrenia", Korean J Schizophr Res, 6, pp.63~69 (2003)
- Thippaiah SM, "Switching antipsychotics : a guide to dose equivalents", Curr Psychiatry, 20, pp.13~14 (2021)
- Ayesa-Arriola R, "No sex differences in neuropsychological performance in first episode psychosis patients", Prog Neuropsychopharmacol Biol Psychiatry, 48, pp.149~154 (2014)
- Vila-Badia R, "Cognitive functioning in first episode psychosis. Gender differences and relation with clinical variables", Early Interv Psychiatry, 15, pp.1667~1676 (2021)
- Wei CW, "Sex differences in the association of body mass index with symptoms and cognitive deficits in Chinese patients with chronic schizophrenia", Transl Psychiatry, 10, pp.18~ (2020)
- Zhang B, "Gender differences measured by the MATRICS consensus cognitive battery in chronic schizophrenia patients", Sci Rep, 7, pp.11821~ (2017)
- Pu C, "Gender differences of neurocognitive functioning in patients with first-episode schizophrenia in China", Compr Psychiatry, 95, pp.152132~ (2019)
- Mu L, "Sex differences in association between clinical correlates and cognitive impairment in patients with chronic schizophrenia", J Psychiatr Res, 131, pp.194~202 (2020)
- Ruiz JC, "Gender differences on the WAIS-IV in patients with schizophrenia", Salud Ment, 44, pp.17~23 (2021)
- Mendrek A, "Sex", gender differences in the brain and cognition in schizophrenia, 2016, pp.67, 57~78
- Ko MA, "Comparative study of clinical features between early- and late-onset schizophrenia in South Korea", Korean J Schizophr Res, 22, pp.51~55 (2019)
- Fu S, "Cognitive improvement in first-episode schizophrenia and healthy controls : a 6-year multi-assessment follow-up study", Psychiatry Res, 267, pp.319~326 (2018)
- Bora E, "Meta-analysis of cognitive deficits in ultra-high risk to psychosis and first-episode psychosis : do the cognitive deficits progress over, or after, the onset of psychosis?", Schizophr Bull, 40, pp.744~755 (2014)
- Dickson H, "Academic achievement and schizophrenia : a systematic meta-analysis", Psychol Med, 50, pp.1949~1965 (2020)
- Russell AJ, "Schizophrenia and the myth of intellectual decline", Am J Psychiatry, 154, pp.635~639 (1997)
- Seeman MV, "Subjective overview of accelerated aging in schizophrenia", Int J Environ Res Public Health, 20, pp.737~ (2022)