당나귀육 열수 추출물이 Streptozotocin (STZ)으로 유발시킨 당뇨쥐의 혈당에 미치는 영향
Effect of Donkey Meat Extract on Streptozotocin (STZ) Induced Diabetes in Rats
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The present study was performed to determine beneficial effects of donkey meat extract supplementation (15 and 30 mg/kg B.W.) on streptozotocin (STZ) induced diabetic rat. Rump muscle of donkey was extracted by boiling in water for 3 hrs and supplemented to STZ induced diabetic rats for 6 weeks. Feed and water intake of STZ induced diabetic rats were higher than those of normal rats, while no significant difference was found in DME treated rats as compared to the rats in control group. STZ-induced diabetic rats did not improved their body weight as compared to that of rats in the control group. However, blood glucose level of 30 mg DME supplemented rats was found to be significantly reduced after 4 weeks of supplementation (p<0.05) when compared to the control animals. Administration of DME did not show any improving effect on serum lipids (HDL-cholesterol, total cholesterol, and triglyceride). No significant changes were noticed in terms of weight of all the visceral organs of animals fed on DME except liver. It is therefore, concluded that supplementation of DME with dose of 30 mg/B.W. resulted in decreased blood glucose levels, however, blood lipid profile of diabetic rats, having more than 400 mg/dl glucose level, did not change.
Abstract
The present study was performed to determine beneficial effects of donkey meat extract supplementation (15 and 30 mg/kg B.W.) on streptozotocin (STZ) induced diabetic rat. Rump muscle of donkey was extracted by boiling in water for 3 hrs and supplemented to STZ induced diabetic rats for 6 weeks. Feed and water intake of STZ induced diabetic rats were higher than those of normal rats, while no significant difference was found in DME treated rats as compared to the rats in control group. STZ-induced diabetic rats did not improved their body weight as compared to that of rats in the control group. However, blood glucose level of 30 mg DME supplemented rats was found to be significantly reduced after 4 weeks of supplementation (p<0.05) when compared to the control animals. Administration of DME did not show any improving effect on serum lipids (HDL-cholesterol, total cholesterol, and triglyceride). No significant changes were noticed in terms of weight of all the visceral organs of animals fed on DME except liver. It is therefore, concluded that supplementation of DME with dose of 30 mg/B.W. resulted in decreased blood glucose levels, however, blood lipid profile of diabetic rats, having more than 400 mg/dl glucose level, did not change.
참고문헌 (19)
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