돼지감자 추출액이 Streptozotocin으로 유발된 당뇨쥐에서 혈당 및 지질대사에 미치는 효과
Effects of Jerusalem Artichoke (Helianthus tuberosus L.) Extracts on Blood Glucose and Lipid Metabolism in STZ-induced Diabetic Rats
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초록
This study investigated the effect of Jerusalem artichoke (Helianthus tuberosus L.) extract on Blood Glucose and Lipid Metabolism in Streptozotocin (70 mg/kg B.W., i.p.)-induced Diabetic Rats. Sprague-Dawley male rats (200∼220 g) were divided into normal control group (NC), diabetic control group (DC) and Jerusalem artichoke treated diabetic group (DJ). Diabetes was induced by single intraperitoneal injection of streptozotocin as a dose of 70 mg/kg body weight. Food (p＜0.001) and water (p＜0.05) intakes were higher in diabetic groups than the normal group. Body weight gain and food efficiency ratio were significantly lower in diabetic groups than normal group (p＜0.01). However, they were higher in the DJ group than in the DC group. The serum levels of AST and ALT were significantly lower in the DJ group than in the DC group (p＜0.05). The serum level of HDL-C was significantly higher in the DJ group than in the DC group (p＜0.001). The serum levels of Triglyceride (p＜0.05), LDL-C (p＜0.001), and glucose (p＜0.001) were significantly lower in the DJ group than in the DC group. At 3 and 4 weeks after the experiment, blood glucose level in the DJ group was significantly lower than the DC group (p＜0.05). In conclusion, these results indicated that Jerusalem artichoke can prevent or retard the development of diabetic complications via its beneficial effects for alleviating the hyperglycemia and improved lipid metabolism.
Abstract
This study investigated the effect of Jerusalem artichoke (Helianthus tuberosus L.) extract on Blood Glucose and Lipid Metabolism in Streptozotocin (70 mg/kg B.W., i.p.)-induced Diabetic Rats. Sprague-Dawley male rats (200∼220 g) were divided into normal control group (NC), diabetic control group (DC) and Jerusalem artichoke treated diabetic group (DJ). Diabetes was induced by single intraperitoneal injection of streptozotocin as a dose of 70 mg/kg body weight. Food (p＜0.001) and water (p＜0.05) intakes were higher in diabetic groups than the normal group. Body weight gain and food efficiency ratio were significantly lower in diabetic groups than normal group (p＜0.01). However, they were higher in the DJ group than in the DC group. The serum levels of AST and ALT were significantly lower in the DJ group than in the DC group (p＜0.05). The serum level of HDL-C was significantly higher in the DJ group than in the DC group (p＜0.001). The serum levels of Triglyceride (p＜0.05), LDL-C (p＜0.001), and glucose (p＜0.001) were significantly lower in the DJ group than in the DC group. At 3 and 4 weeks after the experiment, blood glucose level in the DJ group was significantly lower than the DC group (p＜0.05). In conclusion, these results indicated that Jerusalem artichoke can prevent or retard the development of diabetic complications via its beneficial effects for alleviating the hyperglycemia and improved lipid metabolism.
참고문헌 (25)
- Arbeeny CA, "Inhibition of fatty acid synthesis decrease very-low density lipoprotein secretion in the hamster", J Lipid Res, 33, pp.843~851 (1992)
- Bach V, "Effects of harvest time and variety on sensory quality and chemical composition of Jerusalem artichoke (Helianthus tuberosus) tubers", J Food Chem, 133, pp.82~89 (2012)
- Baltacioglu C, "Chips production from Jerusalem artichoke (Helianthus tuberosus L)", Food Nutr Sci, 3, pp.1321~1328 (2012)
- Bursch W, "Cytoprotective effect of the prostacyclin derivative iloprost against liver cell death induced by the hepatotoxins carbon tetracholoride and brombenzen", Klin Wochenschr, 7, pp.47~50 (1986)
- 최필병, "장기간의 규칙적인 운동과 약물요법이 제2형 당뇨병 환자의 당뇨지표, 혈중지질 및 골밀도에 미치는 영향", 한국체육학회지, 50(3), pp.513~522 (2011), 한국체육학회
- Connelly K, "Clinically relevant models of diabetic cardiac complications", Circ Res, 101(6), pp.78~80 (2007)
- Dunn JS, "Experimental alloxan diabetes in the rat", The Lancet, 242, pp.384~387 (1943)
- Goldberg RB, "Lipid disorders in diabetes", Diabetes Care, 4, pp.561~572 (1981)
- 홍정희, "YK-209 뽕잎이 Streptozotocin 유발 당뇨쥐 간조직에서의 HMG-CoA Reductase 활성과 지질조성에 미치는 영향", 한국식품영양과학회지, 31(5), pp.826~833 (2002), 한국식품영양과학회
- 제갈승주, "스트렙토조토신 유도 당뇨 흰쥐에서 전기자극이 상처치유와 피부 비만세포에 미치는 영향", 대한임상검사과학회지, 40(2), pp.118~128 (2008), 대한임상검사과학회
- 김하늘, "열풍 건조한 돼지감자 분말의 영양성분 및 이화학적 특성 분석", 한국식품과학회지, 46(1), pp.73~78 (2014), 한국식품과학회[DOI]
- 김정란, "HIT-T15 세포에서 돼지감자 추출물의 항당뇨 효과", 한국식품영양과학회지, 39(1), pp.31~35 (2010), 한국식품영양과학회
- Kleessen B, "Jerusalem artichoke and chicory inulin in bakery products affect faecal microbiota of healthy volunteers", Br J Nutr, 98, pp.540~549 (2007)
- Korean Diabetes Association, Korea Centers for Disease Control and Prevention, "Diabetes fact sheet in Korea 2012" (2012), Korean Diabetes Association, Korea Centers for Disease Control and Prevention
- 김인식, "당뇨병 지표와 만성 B 형 간염 바이러스 감염의 상관 관계", 대한임상검사과학회지, 45(1), pp.9~15 (2013), 대한임상검사과학회
- 이준호, "Alloxan 유도 당뇨성 흰쥐에서 조직 중 지질 수준 및 지방산 조성 변화에 관한 연구", 한국식품영양과학회지, 33(8), pp.1273~1278 (2004), 한국식품영양과학회
- Zhiyong Liao, "Antidiabetic Effect of Flavones from Cirsium japonicum DC in Diabetic Rats", Archives of Pharmacal Research, 33(3), pp.353~362 (2010), 대한약학회
- Korea Health Statistics 2010:Korea National Health and Nutrition Examination Surveys (KNHANES V-1), "Ministry of Health and Welfare", Ministry of Health and Welfare, ~ (2010)
- 박찬주, "Hypoglycemic Effect of Jicama (Pachyrhizus erosus) Extract on Streptozotocin-Induced Diabetic Mice", Preventive Nutrition and Food Science, 20(2), pp.88~93 (2015), 한국식품영양과학회[DOI]
- 박소영, "Streptozotocin 유도 당뇨쥐에서 C3G 및 D3G 안토시안이 풍부한 검정콩 CJ-3호 종피 추출물의 혈중지질 개선효과", Journal of Nutrition and Health, 48(4), pp.299~309 (2015), 한국영양학회
- Roberfroid MB, "What is beneficial for health? The concept of functional food", Food Chem Toxicol, 37, pp.1039~1041 (1999)
- Shin SH, "Extraction and analysis of inulin from Jerusalem Artichoke", Food science and industry, 45, pp.50~58 (2012)
- Treayway JL, "Glycogen phosphorylase inhibitors for the treatment of type 2 diabetes mellitus", Expert Opin Investig Drugs, 10, pp.439~454 (2001)
- West KM, "The role of circulating glucose and triglyceride concentrations and their interaction with other "risk factors" as determinants of arterial disease in nine diabetic population samples from the WHO multi-national study", Diabetes Care, 6, pp.361~369 (1983)
- 윤진아, "손바닥선인장의 열매와 줄기가 Streptozotocin으로 유발된 당뇨 쥐의 혈당 및 지질대사에 미치는 영향", 한국식품영양과학회지, 38(2), pp.146~153 (2009), 한국식품영양과학회