본문 바로가기
KERD
논문KCI 등재

혈관성 우울증의 개념, 병인기전, 치료와 예후

The Concept, Pathogenesis, Treatment and Prognosis of Vascular Depression

1

조회

0

다운로드

0

인용

0

참고문헌

키워드

주제분류정신과학

초록

Since the hypothesis suggesting vascular depression to be a subtype of late-life depression was formulated in the late 1990s, many studies have been conducted to prove the hypothesis. However, controversies surrounding the definition and concept of vascular depression have made it difficult to integrate and apply the knowledge gained from previous studies. The diagnostic validity of vascular depression has not been firmly established ; nevertheless, many researchers argue that the clinical value of vascular depression should be assessed and emphasize the need for further investigation. In this article, the author explores various issues about the concepts, mechanisms, treatments, and prognosis of vascular depression by reviewing many critical papers discussing the vascular depression hypothesis. If the vascular depression hypothesis is substantiated through further research, it will have important clinical implications in understanding the pathogenesis, treatment, and prevention of late-life depression.

Abstract

Since the hypothesis suggesting vascular depression to be a subtype of late-life depression was formulated in the late 1990s, many studies have been conducted to prove the hypothesis. However, controversies surrounding the definition and concept of vascular depression have made it difficult to integrate and apply the knowledge gained from previous studies. The diagnostic validity of vascular depression has not been firmly established ; nevertheless, many researchers argue that the clinical value of vascular depression should be assessed and emphasize the need for further investigation. In this article, the author explores various issues about the concepts, mechanisms, treatments, and prognosis of vascular depression by reviewing many critical papers discussing the vascular depression hypothesis. If the vascular depression hypothesis is substantiated through further research, it will have important clinical implications in understanding the pathogenesis, treatment, and prevention of late-life depression.

참고문헌 (60)

  1. Alexopoulos GS, "‘Vascular depression’ hypothesis", Arch Gen Psychiatry, 54, pp.915~922 (1997)
  2. Alexopoulos GS, "Clinically defined vascular depression", Am J Psychiatry, 154, pp.562~565 (1997)
  3. Sneed JR, "The vascular depression hypothesis : an update", Am J Geriatr Psychiatry, 19, pp.99~103 (2011)
  4. Steffens DC, "Structural neuroimaging and mood disorders: recent findings, implications for classification, and future directions", Biol Psychiatry, 43, pp.705~712 (1998)
  5. Krishnan KR, "Clinical characteristics of magnetic resonance imaging-defined subcortical ischemic depression", Biol Psychiatry, 55, pp.390~397 (2004)
  6. Alexopoulos GS, "Clinical presentation of the"depression-executive dysfunction syndrome"of late life", Am J Geriatr Psychiatry, 10, pp.98~106 (2002)
  7. Alexopoulos GS, "Role of executive function in late-life depression", J Clin Psychiatry, 64(Suppl 14), pp.18~23 (2003)
  8. Alexopoulos GS, "The vascular depression hypothesis : 10 years later", Biol Psychiatry, 60, pp.1304~1305 (2006)
  9. Kim BS, "The role of vascular risk factors in the development of DED syndrome among an elderly community sample", Am J Geriatr Psychiatry, 19, pp.104~114 (2011)
  10. Sneed JR, "The vascular depression subtype : evidence of internal validity", Biol Psychiatry, 64, pp.491~497 (2008)
  11. Robins E, "Establishment of diagnostic validity in psychiatric illness : its application to schizophrenia", Am J Psychiatry, 126, pp.983~987 (1970)
  12. Starkstein SE, "Comparison of cortical and subcortical lesions in the production of poststroke mood disorders", Brain, 110(Pt 4), pp.1045~1059 (1987)
  13. Astrom M, "Major depression in stroke patients. A 3-year longitudinal study", Stroke, 24, pp.976~982 (1993)
  14. Firbank MJ, "A volumetric study of MRI signal hyperintensities in late-life depression", Am J Geriatr Psychiatry, 12, pp.606~612 (2004)
  15. Greenwald BS, "Neuroanatomic localization of magnetic resonance imaging signal hyperintensities in geriatric depression", Stroke, 29, pp.613~617 (1998)
  16. Taylor WD, "White matter hyperintensity progression and late-life depression outcomes", Arch Gen Psychiatry, 60, pp.1090~1096 (2003)
  17. Krishnan MS, "Relationship between periventricular and deep white matter lesions and depressive symptoms in older people. The LADIS Study", Int J Geriatr Psychiatry, 21, pp.983~989 (2006)
  18. Nebes RD, "Relationship of deep white matter hyperintensities and apolipoprotein E genotype to depressive symptoms in older adults without clinical depression", Am J Psychiatry, 158, pp.878~884 (2001)
  19. Iidaka T, "Signal hyperintensities on brain magnetic resonance imaging in elderly depressed patients", Eur Neurol, 36, pp.293~299 (1996)
  20. Alexander GE, "Parallel organization of functionally segregated circuits linking basal ganglia and cortex", Annu Rev Neurosci, 9, pp.357~381 (1986)
  21. Thomas AJ, "Ischemic basis for deep white matter hyperintensities in major depression : a neuropathological study", Arch Gen Psychiatry, 59, pp.785~792 (2002)
  22. Boone KB, "Neuropsychological correlates of white-matter lesions in healthy elderly subjects", Arch Neurol, 49, pp.549~554 (1992)
  23. Figiel GS, "Subcortical hyperintensities on brain magnetic resonance imaging : a comparison between late age onset and early onset elderly depressed subjects", Neurobiol Aging, 12, pp.245~247 (1991)
  24. Krishnan KR, "Neuroanatomical substrates of depression in the elderly", Eur Arch Psychiatry Clin Neurosci, 243, pp.41~46 (1993)
  25. Herrmann LL, "White matter hyperintensities in late life depression : a systematic review", J Neurol Neurosurg Psychiatry, 79, pp.619~624 (2008)
  26. Bae JN, "Dorsolateral prefrontal cortex and anterior cingulate cortex white matter alterations in latelife depression", Biol Psychiatry, 60, pp.1356~1363 (2006)
  27. Taylor WD, "Late-life depression and microstructural abnormalities in dorsolateral prefrontal cortex white matter", Am J Psychiatry, 161, pp.1293~1296 (2004)
  28. Kim JS, "Cytokines and adhesion molecules in stroke and related diseases", J Neurol Sci, 137, pp.69~78 (1996)
  29. Connor TJ, "Depression, stress and immunological activation: the role of cytokines in depressive disorders", Life Sci, 62, pp.583~606 (1998)
  30. Lee KS, "Simultaneous measurement of 23 plasma cytokines in late-life depression", Neurol Sci, 30, pp.435~438 (2009)
  31. Diniz BS, "Interleukin-1beta serum levels is increased in antidepressant-free elderly depressed patients", Am J Geriatr Psychiatry, 18, pp.172~176 (2010)
  32. Thomas AJ, "Increase in interleukin-1beta in late-life depression", Am J Psychiatry, 162, pp.175~177 (2005)
  33. Musselman DL, "Higher than normal plasma interleukin-6 concentrations in cancer patients with depression : preliminary findings", Am J Psychiatry, 158, pp.1252~1257 (2001)
  34. Bremmer MA, "Inflammatory markers in late-life depression : results from a population-based study", J Affect Disord, 106, pp.249~255 (2008)
  35. Holley C, "Psychosocial and vascular risk factors for depression in the elderly", Am J Geriatr Psychiatry, 14, pp.84~90 (2006)
  36. Pickering TG, "Stress, inflammation, and hypertension", J Clin Hypertens, 9, pp.567~571 (2007)
  37. Black PH, "Stress, inflammation and cardio-vascular disease", J Psychosom Res, 52, pp.1~23 (2002)
  38. Hickie I, "Subcortical hyperintensities on magnetic resonance imaging : clinical correlates and prognostic significance in patients with severe depression", Biol Psychiatry, 37, pp.151~160 (1995)
  39. Simpson S, "Is subcortical disease associated with a poor response to antidepressants? Neurological, neuropsychological and neuroradiological findings in late-life depression", Psychol Med, 28, pp.1015~1026 (1998)
  40. Sneed JR, "Response inhibition predicts poor antidepressant treatment response in very old depressed patients", Am J Geriatr Psychiatry, 15, pp.553~563 (2007)
  41. Alexopoulos GS, "Executive dysfunction and the course of geriatric depression", Biol Psychiatry, 58, pp.204~210 (2005)
  42. Alexopoulos GS, "Frontal white matter microstructure and treatment response of late-life depression : a preliminary study", Am J Psychiatry, 159, pp.1929~1932 (2002)
  43. Alexopoulos GS, "Microstructural white matter abnormalities and remission of geriatric depression", Am J Psychiatry, 165, pp.238~244 (2008)
  44. Salloway S, "The relationship of MRI subcortical hyperintensities to treatment response in a trial of sertraline in geriatric depressed outpatients", Am J Geriatr Psychiatry, 10, pp.107~111 (2002)
  45. Krishnan KR, "Six-month outcomes for MRI-related vascular depression", Depress Anxiety, 8, pp.142~146 (1998)
  46. Navarro V, "Prognostic value of frontal functional neuroimaging in late-onset severe major depression", Br J Psychiatry, 184, pp.306~311 (2004)
  47. Hickie I, "Subcortical hyperintensities on magnetic resonance imaging in patients with severe depression--a longitudinal evaluation", Biol Psychiatry, 42, pp.367~374 (1997)
  48. O’Brien J, "Severe deep white matter lesions and outcome in elderly patients with major depressive disorder : follow up study", BMJ, 317, pp.982~984 (1998)
  49. Steffens DC, "Subcortical white matter lesions and functional impairment in geriatric depression", Depress Anxiety, 15, pp.23~28 (2002)
  50. Alexopoulos GS, "Executive dysfunction and long-term outcomes of geriatric depression", Arch Gen Psychiatry, 57, pp.285~290 (2000)
  51. Butters MA, "Executive functioning, illness course, and relapse", recurrence in continuation and maintenance treatment of late-life depression: is there a relationship?, 2004, pp.12, 387~394
  52. Cui X, "Does depression precede or follow executive dysfunction? Outcomes in older primary care patients", Am J Psychiatry, 164, pp.1221~1228 (2007)
  53. Krishnan KR, "MRI-defined vascular depression", Am J Psychiatry, 154, pp.497~501 (1997)
  54. Kiosses DN, "Symptoms of striatofrontal dysfunction contribute to disability in geriatric depression", Int J Geriatr Psychiatry, 15, pp.992~999 (2000)
  55. Kiosses DN, "Executive dysfunction and disability in elderly patients with major depression", Am J Geriatr Psychiatry, 9, pp.269~274 (2001)
  56. Jorge RE, "Treatment of vascular depression using repetitive transcranial magnetic stimulation", Arch Gen Psychiatry, 65, pp.268~276 (2008)
  57. Taragano FE, "A double blind, randomized clinical trial assessing the efficacy and safety of augmenting standard antidepressant therapy with nimodipine in the treatment of ‘vascular depression’", Int J Geriatr Psychiatry, 16, pp.254~260 (2001)
  58. Taragano FE, "A double-blind, randomized clinical trial to assess the augmentation with nimodipine of antidepressant therapy in the treatment of “vascular depression”", Int Psychogeriatr, 17, pp.487~498 (2005)
  59. Alexopoulos GS, "Problem-solving therapy versus supportive therapy in geriatric major depression with executive dysfunction", Am J Geriatr Psychiatry, 11, pp.46~52 (2003)
  60. Alexopoulos GS, "Problem-solving therapy and supportive therapy in older adults with major depression and executive dysfunction : effect on disability", Arch Gen Psychiatry, 68, pp.33~41 (2011)

관련 논문AI추천

이 간행물의 다른 논문 (9건)