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경도인지장애에서 뇌자기공명영상검사상 백질병소에 관현 연구

White Matter Lesions on Magnetic Resonance Imaging in Mild Cognitive Impairment

오병훈|전진숙|전갑수|조원용|송혜란
대한생물치료정신의학회 (Korean Society Of Biological Therapies In Psychiatry)|2006.06|생물치료정신의학 (Journal of the Korean Society of Biological Therapies in Psychiatry)|제12권 제1호|pp. 93-103

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참고문헌

키워드

경도인지장애 뇌백질병소 심부백질고강도영상 뇌실변고강도영상 고혈압.
주제분류정신과학

초록

연구목적 : 경도인지장애에서 뇌 백질병소의 빈도와 이에 관련되는 인자를 알아보기 위함이다. 연구방법 : 경도인지장애군(N=30), 알쯔하이머형 치매군(N=34) 및 정상노인대조군(N=20)에서 뇌자기공명영상검사상 백질병소(뇌실변고강도영상, 심부백질고상도영상)를 분석 비교한다. 또한 뇌혈관장애위험인자를 포함하는 여러 변인과의 관련성도 검토한다. 연구결과 : 1) 3도의 심한 뇌실변고강도영상의 빈도는 정상노인군 5.0%, 경도인지장애군 16.6%, 알쯔하이머형 치매군 38.2%로서 세 군간에 통계적으로 유의한 차이가 있었다(p<0.05). 그러나, 3도의 심한 심부백질고강도영상은 정상 노인군 10.0%, 경도인지장애군 23.3%, 알쯔하이머형 치매군 35.3%로서 세 군간에 통계적으로 유의한 차이가 없었다. 2) 정상노인군, 경도인지장애군, 알쯔하이머형 치매군에서 여러 뇌혈관장애 위험인자의 빈도는 세 군간에 유의한 차이가 없었다. 3) 뇌백질병소 중에서 뇌실변고강도영상의 심한 정도는 연령(p<0.05), 수축기혈압(p<0.05) 및 이완기혈압(p<0.005)에 관계되며, 심부백질고강도영상은 성별(p<0.05), 교육수준(p<0.05), Global Deterioration Scale(p<0.05), 수축기혈압(p<0.01) 및 이완기혈압(p<0.05)에 관계되었다.

Abstract

Objectives : The aims of this study were to know the frequency of white matter lesions (WMLs) on brain magnetic resonance imaging (MRI) in patients with mild cognitive impairment (MCI), and to identify related factors. Methods : Among WMLs, periventricular hyperintensities (PVHs) and deep white matter hyperintensities (DWMHs) on brain MRI in patients with MCI (N=30), patients with dementia of the Alzheimer's type (DAT) (N=34) and normal aged controls (N=20)were analyzed. Furthermore, related variables including cardiovascular risk factors werediscussed. Results : 1) The frequencies of the third degree PVHs in patients with MCI (16.6%) were significantly different from those of normal aged controls (5.0%), and from those of patients with DAT (38.2%) (p<0.05). However, frequencies of the third degree DWMHs in patients with MCI (23.3%) were not different from those of normal aged controls (10.0%), and from those of patients with DAT (35.3%). 2) The frequencies of various cardiovascular risk factors in patients with MCI, patients with DAT and normal aged controls were not significantly different.3) The severity of PVLs seemed to be related to age (p<0.05), systolic blood pressure (p<0.05) and diastolic blood pressure (p<0.005). The severity of DWMHs were seemed to be related to sex (p<0.05), education (p<0.05), Global Deterioration Scale (p<0.05), systolic blood pressure (p<0.01) and diastolic blood pressure (p<0.05).Conclusions : The PVHs might be useful to discriminate patients with MCI from normal aged person. Active management of hypertension seemed to be crucial to prevent from development of WMLs.

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